The effect of HAART on salivary microbiota in the women's Interagency HIV study (WIHS)
Abstract
Objective Study the prevalence of potentially pathogenic microorganisms in saliva of HIV-positive women in the Women's Interagency HIV Study. Study design 157 HIV-positive and 31 HIV-negative women were studied. At baseline and every 6 months over 4 years, information was collected on socioeconomic and educational status, oral and systemic health, including HIV markers and antiretroviral therapy, and frequency of professional oral care utilization. Bacterial and yeast pathogenic isolates from stimulated whole saliva were tentatively identified using standard methodologies. Results The prevalence of microorganisms in stimulated saliva of HIV-positive women was not significantly different from that of HIV-negative women. In HIV-positive women, highly active antiretroviral therapy (HAART) was independently and significantly associated with the presence of a variety of salivary bacterial species. HAART increased the risk for recovering Fusobacterium species (P Conclusion The present findings suggest that the institution of HAART promotes an increasingly pathogenic salivary microbiota, at least temporarily. Similar findings have been reported for various nonoral microbial ecosystems.
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Several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis, HIV, and cystic fibrosis, also feature dysregulated salivary flow and altered oral microbial populations.
“Significantly, several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis[294–297], HIV[7,11], and cystic fibrosis[298] also feature dysregulated salivary flow[299–302] and altered oral microbial populations[224,303–306].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [303]
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- Authors
- Navazesh, M., Mulligan, R., Pogoda, J., Greenspan, D., Alves, M., Phelan, J., Greenspan, J., & Slots, J.
- Affiliations
- University of Southern California (US)
- University of California, San Francisco (US)
- University of Illinois Chicago (US)
- New York University (US)
- Corresponding author
- Navazesh, Mavash
- Venue
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 100
- Issue
- 6
- Pages
- 701-708
- ISSN
- 1079-2104 (ISSN-L)
- OpenAlex
- W2048613505
- Cited by
- 33
- References
- 63
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (U01 AI42590, U01-AI-31834, U01AI034989, U01AI031834, U01AI042590, U01-AI-34993, U01AI34994, U01AI034993, U01-AI-34989, U01AI034994, U-01-AI-35004, U01AI035004)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01- HD-32632, U01HD032632)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- highly active antiretroviral therapy, salivary microbiota, women living with HIV, oral candidiasis, Candida albicans, Candida dubliniensis, Fusobacterium, Peptostreptococcus micros, Campylobacter, Tannerella forsythia, oral bacteria, oral yeasts
- MeSH terms
- Adolescent, Adult, Bacteria, Anaerobic, Female, Gram-Negative Bacteria, Humans, Longitudinal Studies, Middle Aged, Saliva, HIV Infections, Logistic Models, Odds Ratio, Case-Control Studies, Antiretroviral Therapy, Highly Active
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