Oxidized phospholipids in control of inflammation and endothelial barrier
Open accessAbstract
The levels of circulating oxidized phospholipids (OxPLs) become increased in chronic and acute pathologic conditions such as hyperlipidemia, atherosclerosis, increased intimamedia thickness in the patients with systemic Lupus erythematosus, vascular balloon injury, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). These pathologies are associated with inflammation and activation of endothelial cells. Depending on the biological context and the specific group of phospholipid oxidation products, OxPL may exhibit both proinflammatory and anti-inflammatory effects. This review will summarize the data showing a dual role of OxPL in modulation of chronic and acute inflammation as well as OxPL effects on pulmonary endothelial permeability. Recent reports show protective effects of OxPL in the models of endotoxin and ventilator-induced ALI and suggest a potential for using OxPL-derived cyclopenthenone-containing compounds with barrier-protective properties for drug design. These compounds may represent a new group of therapeutic agents for the treatment of lung syndromes associated with acute inflammation and lung vascular leak.
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OxPLs in oxLDL activate endothelial cells and control endothelial barrier permeability, and oxPLs released from dying cells are captured by CD14 on dendritic cells, causing inflammasome-dependent phagocyte hyperactivation.
“the oxPLs present in oxLDL activate endothelial cells and control the endothelial barrier permeability52,53, and oxPLs released from dying cells are captured by the CD14 receptor on dendritic cells, with ensuing inflammasome-dependent phagocyte hyperactivation54.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [53]
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
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- Authors
- Fu, P., & Birukov, K. G.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Birukov, Konstantin G.
- Venue
- Translational Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 153
- Issue
- 4
- Pages
- 166-176
- ISSN
- 1878-1810 (ISSN-L)
- 1931-5244
- PMC
- PMC3677584
- OpenAlex
- W2078255669
- Cited by
- 86
- References
- 77
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 7
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Translational research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institutes of Health (HL58064)
- National Heart, Lung, and Blood Institute (HL-76259, HL 58064, R01HL076259, P01HL058064, P01HL 58064)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidized phospholipids, inflammation, endothelial barrier, pulmonary endothelial permeability, acute lung injury, acute respiratory distress syndrome, endotoxin, ventilator-induced lung injury, atherosclerosis, systemic lupus erythematosus, vascular leakage
- MeSH terms
- Animals, Endothelium, Humans, Inflammation, Oxidation-Reduction, Phospholipids, Receptors, LDL, Signal Transduction
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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