Cited by 251Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational Health and Global Justice

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Asbestos-induced lung diseases: an update

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Kamp, David W.·2009·Translational Research

DOI 10.1016/j.trsl.2009.01.004PMC PMC3544481

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Abstract

Asbestos causes asbestosis (pulmonary fibrosis caused by asbestos inhalation) and malignancies (bronchogenic carcinoma and mesothelioma) by mechanisms that are not fully elucidated. Despite a dramatic reduction in asbestos use worldwide, asbestos-induced lung diseases remain a substantial health concern primarily because of the vast amounts of fibers that have been mined, processed, and used during the 20th century combined with the long latency period of up to 40 years between exposure and disease presentation. This review summarizes the important new epidemiologic and pathogenic information that has emerged over the past several years. Whereas the development of asbestosis is directly associated with the magnitude and duration of asbestos exposure, the development of a malignant clone of cells can occur in the setting of low-level asbestos exposure. Emphasis is placed on the recent epidemiologic investigations that explore the malignancy risk that occurs from nonoccupational, environmental asbestos exposure. Accumulating studies are shedding light on novel mechanistic pathways by which asbestos damages the lung. Attention is focused on the importance of alveolar epithelial cell (AEC) injury and repair, the role of iron-derived reactive oxygen species (ROS), and apoptosis by the p53- and mitochondria-regulated death pathways. Furthermore, recent evidence underscores crucial roles for specific cellular signaling pathways that regulate the production of cytokines and growth factors. An evolving role for epithelial-mesenchymal transition (EMT) is also reviewed. The translational significance of these studies is evident in providing the molecular basis for developing novel therapeutic strategies for asbestos-related lung diseases and, importantly, other pulmonary diseases, such as interstitial pulmonary fibrosis and lung cancer.

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Screening for Mesothelioma
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2 of the 111 references couldn’t be matched to a known paper.

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Kamp, 2002, Asbestos-associated cancers: clinical spectrum and pathogenic mechanisms, Clin Occup Environ Med, 2, 753, 10.1016/S1526-0046(03)00023-2 · DOI

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Germline BAP1 Mutations Predispose to Malignant Mesothelioma
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See all 251

Authors: Kamp, D. W.
Affiliations: Northwestern University (US)
Corresponding author: Kamp, David W.
Venue: Translational Research
Publisher: Elsevier BV
Published: 2009-04
Volume: 153
Issue: 4
Pages: 143-152
ISSN: 1878-1810 (ISSN-L)
1931-5244
DOI: 10.1016/j.trsl.2009.01.004
PMC: PMC3544481
OpenAlex: W2115450306
Cited by: 251
References: 111
Citations by year: 2026: 4 · 2025: 12 · 2024: 11 · 2023: 17 · 2022: 9 · 2021: 17 · 2020: 12 · 2019: 12 · 2018: 10 · 2017: 11 · 2016: 6 · 2015: 15 · 2014: 22 · 2013: 27 · 2012: 22
FWCI: 3.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Translational research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL035440)
National Institute of Environmental Health Sciences (R01ES013995)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Social Sciences › Health › Occupational Health and Global Justice
Keywords: asbestos, asbestosis, pulmonary fibrosis, mesothelioma, lung cancer, asbestos exposure, environmental asbestos exposure, alveolar epithelial cells, reactive oxygen species, iron, apoptosis, p53, mitochondrial apoptosis, cytokines, growth factors, epithelial-mesenchymal transition, interstitial pulmonary fibrosis, latency period, pathogenesis
MeSH terms: Asbestos, Humans, Lung Diseases

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