The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus
Abstract
The objective of this study is to evaluate the specificity and sensitivity of antinucleosome, anti-C1q, and anti-dsDNA antibodies for detecting concurrent disease activity in systemic lupus erythematosus (SLE). Consecutive patients were recruited for serological testing of anti-dsDNA, IgG-antinucleosome, IgG-anti-C1q, and complement levels. SLE disease activity was assessed by SLEDAI and physician's global assessment (PGA). The levels of these antibodies, complements, and disease activity scores were correlated. The specificity and sensitivity of these antibodies in detecting SLE activity was determined. We recruited 245 SLE patients (95% women, age 40.6 ± 12.2 years). The prevalence of positive anti-dsDNA, antinucleosome and anti-C1q antibodies was 55%, 44%, and 21%, respectively. All 3 antibodies correlated significantly with SLEDAI and PGA scores but were correlated inversely with complement levels (P < 0.001 in all). Titers of anti-dsDNA and anti-C1q, but not antinucleosome, correlated significantly with the renal SLEDAI score. The sensitivity of anti-dsDNA, antinucleosome, and anti-C1q for detecting the presence of active renal disease was 75%, 47%, and 53%, respectively. Anti-C1q had the highest specificity for active lupus renal disease (84%) followed by antinucleosome (57%) and the anti-dsDNA antibody (49%). The negative predictive value (NPV) of a negative anti-dsDNA and anti-C1q for active renal disease was 91%. For concurrent extrarenal SLE activity, the specificity was also highest with anti-C1q (83%). We conclude that antinucleosome does not perform better than anti-dsDNA for detecting concurrent SLE activity. The anti-C1q antibody, however, is more specific than anti-dsDNA for both active renal and extrarenal lupus. The absence of both anti-dsDNA and anti-C1q has a high NPV for renal activity.
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“As double-stranded DNA (dsDNA) antibodies are among the most commonly detected ANAs in SLE, reported to correlate also with disease activity and especially renal involvement (6-9)”
From Anti-dsDNA Testing Specificity for Systemic Lupus Erythematosus: A Systematic Review. (2022) · cites this paper as [9]
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
Combined Oral Contraceptives in Women with Systemic Lupus Erythematosus
Petri, M., Kim, M. Y., Kalunian, K. C., Grossman, J., Hahn, B. H., Sammaritano, L. R., Lockshin, M., Merrill, J. T., Belmont, H. M., Askanase, A. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051135 · Cited by 1,166
Amoura, Z., Koutouzov, S., Chabre, H., Cacoub, P., Amoura, I., Musset, L., Bach, J.-F., & Piette, J.-C. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1<76::aid-anr10>3.0.co;2-i · Cited by 244
Badger, A. M., Griswold, D. E., Kapadia, R. D., Blake, S. M., Swift, B. A., Hoffman, S. J., Stroup, G. B., Webb, E. F., Rieman, D. J., Gowen, M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1<1::aid-anr1>3.0.co;2-6 · Cited by 213
Validity and reliability of lupus activity measures in the routine clinic setting.
Petri, M., Hellmann, D. B., & Hochberg, M. C. (1992) · PubMed · Cited by 204
Kalaaji, M., Fenton, K.-A., Mortensen, E.-S., Olsen, R., Sturfelt, G., Alm, P., & Rekvig, O.-P. (2007) · Kidney International · doi:10.1038/sj.ki.5002133 · Cited by 195
Biomarkers for Lupus Nephritis: A Critical Appraisal
Mok, C. C. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/638413 · Cited by 189
Moroni, G., Radice, A., Giammarresi, G., Quaglini, S., Gallelli, B., Leoni, A., Vecchi, M. L., Messa, P., & Sinico, R. A. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.094508 · Cited by 170
Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus.
Siegert, C. E. H., Daha, M. R., Tseng, C. M., Coremans, I. E. M., van Es, L. A., & Breedveld, F. C. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.12.851 · Cited by 134
Manson, J. J., Ma, A., Rogers, P., Mason, L. J., Berden, J. H., van der Vlag, J., D'Cruz, D. P., Isenberg, D. A., & Rahman, A. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2831 · Cited by 129
Research works printed but not linked: 1
- Bruns, 2000, Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus, Arthritis Rheum, 43, 2307, 10.1002/1529-0131(200010)43:10<2307::AID-ANR19>3.0.CO;2-J · doi:10.1002/1529-0131(200010)43:10<2307::aid-anr19>3.0.co;2-j
Cited by
Bertsias, G. K., Tektonidou, M., Amoura, Z., Aringer, M., Bajema, I., Berden, J. H. M., Boletis, J., Cervera, R., Dörner, T., Doria, A., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201940 · Cited by 1,007
Gordon, C., Amissah-Arthur, M.-B., Gayed, M., Brown, S., Bruce, I. N., D’Cruz, D., Empson, B., Griffiths, B., Jayne, D., Khamashta, M., et al. (2018) · Rheumatology · doi:10.1093/rheumatology/kex286 · Cited by 365
Lupus nephritis: A critical review
Borchers, A. T., Leibushor, N., Naguwa, S. M., Cheema, G. S., Shoenfeld, Y., & Gershwin, M. E. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.08.018 · Cited by 229
Frazzei, G., van Vollenhoven, R., de Jong, B. A., Siegelaar, S. E., & van Schaardenburg, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899372 · Cited by 138
Mok, C., Birmingham, D., Ho, L., Hebert, L., Song, H., & Rovin, B. H. (2011) · Lupus · doi:10.1177/0961203311422094 · Cited by 124
Metadata
- Authors
- Mok, C. C., Ho, L. Y., Leung, H. W., & Wong, L. G.
- Affiliations
- Tuen Mun Hospital (CN)
- Corresponding author
- Mok, Chi Chiu
- Venue
- Translational research
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 156
- Issue
- 6
- Pages
- 320-325
- ISSN
- 1878-1810 (ISSN-L)
- 1931-5244
- OpenAlex
- W2004622563
- Cited by
- 56
- References
- 28
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 9
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Translational research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- systemic lupus erythematosus, anti-C1q antibodies, anti-nucleosome antibodies, anti-dsDNA antibodies, disease activity, lupus nephritis, complement levels, serological markers, sensitivity and specificity, negative predictive value
- MeSH terms
- Adult, Antibodies, Antinuclear, Cross-Sectional Studies, DNA, Female, Humans, Immunoglobulin G, Kidney Diseases, Lupus Erythematosus, Systemic, Male, Middle Aged, Predictive Value of Tests, Sensitivity and Specificity, Complement C1q
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- Mok, C. C., Ho, L. Y., Leung, H. W., & Wong, L. G. (2010). Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus. Translational research. https://doi.org/10.1016/j.trsl.2010.07.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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