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Mitochondria in innate immune signaling
Open accessAbstract
Mitochondria are functionally versatile organelles. In addition to their conventional role of meeting the cell's energy requirements, mitochondria also actively regulate innate immune responses against infectious and sterile insults. Components of mitochondria, when released or exposed in response to dysfunction or damage, can be directly recognized by receptors of the innate immune system and trigger an immune response. In addition, despite initiation that may be independent from mitochondria, numerous innate immune responses are still subject to mitochondrial regulation as discrete steps of their signaling cascades occur on mitochondria or require mitochondrial components. Finally, mitochondrial metabolites and the metabolic state of the mitochondria within an innate immune cell modulate the precise immune response and shape the direction and character of that cell's response to stimuli. Together, these pathways result in a nuanced and very specific regulation of innate immune responses by mitochondria.
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“Mitochondrial debris were observed in blood in the Twin Study (Garrett-Bakelman et al., 2019) and mitochondrial damage-associated molecular patterns (DAMPs) activate innate immune pathways (Banoth and Cassel, 2018; Zhang et al., 2010).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Banoth and Cassel, 2018
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Metadata
- Authors
- Banoth, B., & Cassel, S. L.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Cassel, Suzanne L.
- ORCID
- Banoth, Balaji
- Venue
- Translational Research
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 202
- Pages
- 52-68
- ISSN
- 1878-1810 (ISSN-L)
- 1931-5244
- PMC
- PMC6218307
- OpenAlex
- W2887324910
- Cited by
- 410
- References
- 207
- Citations by year
- 2026: 40 · 2025: 55 · 2024: 68 · 2023: 70 · 2022: 65 · 2021: 54 · 2020: 38 · 2019: 17 · 2018: 2
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Translational research (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (AI104706)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- mitochondria, innate immunity, mitochondrial signaling, sterile inflammation, mitochondrial damage-associated molecular patterns, mitochondrial release, mitochondrial metabolites, mitochondrial metabolism, immune cell metabolism, innate immune receptors
- MeSH terms
- Alarmins, Animals, DNA, Mitochondrial, Humans, Immunity, Innate, Mitochondria, Models, Biological, Signal Transduction
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