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Mebendazole in parasitic infections other than those caused by soil-transmitted helminths
Abstract
Mebendazole, a benzimidazole carbamate compound, is currently in use for human medical practice against soil-transmitted helminthiasis (STH) and enterobiasis. However, it has been demonstrated that its spectrum of activity is broad and goes beyond those infections. Several studies provide evidence that this drug, taken at higher doses than used for STH and enterobiasis, could be sufficiently effective on some protozoa, nematodes and cestodes.
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“Mebendazole was also shown to be effective against metronidazole-resistant and metronidazole-sensitive T. vaginalis strains in vitro [30,285].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [285]
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Sears, S. D., & O'Hare, J. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.1.144 · Cited by 61
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Cited by
Sorted by citations
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Cañete, R., Escobedo, A. A., Almirall, P., González, M. E., Brito, K., & Cimerman, S.
- Affiliations
- Instituto de Gastroenterología (CU)
- Ministerio de Salud Pública (CU)
- Instituto de Infectologia Emílio Ribas (BR)
- Corresponding author
- Escobedo, A.A.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05
- Volume
- 103
- Issue
- 5
- Pages
- 437-442
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1990451865
- Cited by
- 22
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 2
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Keywords
- mebendazole, benzimidazole carbamates, antiparasitic drugs, protozoan infection, nematode infection, cestode infection, soil-transmitted helminths, enterobiasis, off-label drug use
- MeSH terms
- Adolescent, Animals, Antiparasitic Agents, Child, Child, Preschool, Developing Countries, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Giardiasis, Helminthiasis, Humans, Malaria, Male, Mebendazole, Trichomonas Vaginitis, Treatment Outcome
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