Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: Potential use in companion animals

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

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The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract

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Impact of Nutritional Supplementation on Canine Dermatological Disorders

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Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis

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Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice

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Preferential epithelial expression of type-1 cannabinoid receptor (CB1R) in the developing canine embryo

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Palmitoylethanolamide Regulates Development of Intestinal Radiation Injury in a Mast Cell-Dependent Manner

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Dietary Supplementation with Palmitoyl-Glucosamine Co-Micronized with Curcumin Relieves Osteoarthritis Pain and Benefits Joint Mobility

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Current review of hemp‐based medicines in dogs

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Scalable synthesis of oleoyl ethanolamide by chemical amidation in a mixed solvent

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Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats

Ohara, M., Ohnishi, S., Hosono, H., Yamamoto, K., Fu, Q., Maehara, O., Suda, G., & Sakamoto, N. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00709 · Cited by 24

Lipidomic methodologies applicable to the study of endocannabinoids and related compounds: Endocannabinoidomics

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Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headache

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Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration

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Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows

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Anandamide in primary sensory neurons: too much of a good thing?

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Nonpharmacological Treatment Strategies for the Management of Canine Chronic Inflammatory Enteropathy—A Narrative Review

Isidori, M., Corbee, R. J., & Trabalza‐Marinucci, M. (2022) · Veterinary Sciences · doi:10.3390/vetsci9020037 · Cited by 24

Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain

Nobili, S., Micheli, L., Lucarini, E., Toti, A., Ghelardini, C., & Mannelli, L. D. C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108649 · Cited by 22

Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double‐blind, multicentre, randomized, placebo‐controlled study

Noli, C., della Valle, M. F., Miolo, A., Medori, C., & Schievano, C. (2019) · Veterinary Dermatology · doi:10.1111/vde.12764 · Cited by 20

Involvement of the L‐arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats

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Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague–Dawley rats

Jung, J. I., Lee, H. S., Jeon, Y. E., Kim, S. M., Hong, S. H., Moon, J. M., Lim, C. Y., Kim, Y. H., & Kim, E. J. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00870-3 · Cited by 19

Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis

Chiocchetti, R., Silva, M. D., Aspidi, F., Cunha, R. Z., Gobbo, F., Tagliavia, C., Sarli, G., & Morini, M. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.915896 · Cited by 20

Spatial distribution of cannabinoid receptor 1 and fatty acid amide hydrolase in the cat ovary and oviduct

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The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review

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Is there a role for palmitoylethanolamide in the treatment of depression?

Coppola, M., & Mondola, R. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2013.12.016 · Cited by 19

Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice

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Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study

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Druggable Targets in Endocannabinoid Signaling

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Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function

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Ultramicronized palmitoylethanolamide counteracts the effects of compound 48/80 in a canine skin organ culture model

Abramo, F., Lazzarini, G., Pirone, A., Lenzi, C., Albertini, S., della Valle, M. F., Schievano, C., Vannozzi, I., & Miragliotta, V. (2017) · Veterinary Dermatology · doi:10.1111/vde.12456 · Cited by 16

Palmitoylethanolamide Mitigates Paclitaxel Toxicity in Primary Dorsal Root Ganglion Neurons

Elfarnawany, A., & Dehghani, F. (2022) · Biomolecules · doi:10.3390/biom12121873 · Cited by 15

Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study

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An Improved Method for Synthesis of N‐stearoyl and N‐palmitoylethanolamine

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Evidence‐base for the beneficial effect of nutraceuticals in canine dermatological immune‐mediated inflammatory diseases — A literature review

van Amersfort, K., der Lee, A. J., & Hagen-Plantinga, E. A. (2023) · Veterinary Dermatology · doi:10.1111/vde.13152 · Cited by 16

Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid

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Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function

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Letter to the Editor

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Cannabis use is associated with low plasma endocannabinoid Anandamide in individuals with psychosis

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Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance

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Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathy

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The link between neurology and behavior in veterinary medicine: A review

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Renal Endocannabinoid Dysregulation in Obesity-Induced Chronic Kidney Disease in Humans

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Fatty acid ethanolamides modulate CD36-mRNA through dietary fatty acid manipulation in Syrian Golden hamsters

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Effect of a Mucoadhesive Gel and Dental Scaling on Gingivitis in Dogs

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Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art

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Combining a joint health supplement with tibial plateau leveling osteotomy in dogs with cranial cruciate ligament rupture. An exploratory controlled trial

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Expression of functional TRPV 1 receptor in primary culture of canine keratinocytes

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Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention

Scuderi, C., & Golini, L. (2021) · Animals · doi:10.3390/ani11092584 · Cited by 14

Role of endogenous cannabinoids in ischemia/reperfusion injury following testicular torsion in rats

Beheshtian, A., Salmasi, A., Payabvash, S., Kiumehr, S., Nezami, B. G., Rahimpour, S., Rabani, R., Tavangar, S. M., & Dehpour, A. R. (2008) · International Journal of Urology · doi:10.1111/j.1442-2042.2008.02018.x · Cited by 10

Palmitoylethanolamide: From endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence

Coppola, M., & Mondola, R. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.07.016 · Cited by 9

Endocannabinoid 2-Arachidonoylglycerol Synthesis and Metabolism at Neuronal Nuclear Matrix Fractions Derived from Adult Rat Brain Cortex

Aretxabala, X., del Caño, G. G., Barrondo, S., de Jesús, M. L., González-Burguera, I., Saumell-Esnaola, M., Goicolea, M., & Sallés, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043165 · Cited by 8

Preparation of arachidonoyl ethanolamide by enzymatic amidation of arachidonic acid purified from microbial oil

Chen, Y., Wang, Y., Jin, Q., Wang, X., Hu, J., & Wang, X. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.10.022 · Cited by 8

Effect of an Enteroprotective Complementary Feed on Faecal Markers of Inflammation and Intestinal Microbiota Composition in Weaning Puppies

Meineri, G., Cocolin, L., Morelli, G., Schievano, C., Atuahene, D., & Ferrocino, I. (2023) · Veterinary Sciences · doi:10.3390/vetsci10070434 · Cited by 9

Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example

Raffa, R. B., & Pergolizzi, J. V. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2010.01190.x · Cited by 7

Effects of Two Different Specific Neck Exercise Interventions on Palmitoylethanolamide and Stearoylethanolamide Concentrations in the Interstitium of the Trapezius Muscle in Women with Chronic Neck Shoulder Pain

Ghafouri, N., Ghafouri, B., Fowler, C. J., Larsson, B. K., Turkina, M. V., Karlsson, L., & Gerdle, B. U. C. (2014) · Pain Medicine · doi:10.1111/pme.12486 · Cited by 7

Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency

Hammels, I., Binczek, E., Schmidt‐Soltau, I., Jenke, B., Thomas, A., Vogel, M., Thevis, M., Filipova, D., Papadopoulos, S., & Stoffel, W. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m094664 · Cited by 7

G01 Glupamid: a novel nutraceutical approach to canine and feline osteoarthritis

Miolo, A., Badino, P., Barbero, R., & Re, G. (2006) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2006.00765_2.x · Cited by 7

Dermatology: Endocannabinoids and Related N-Acylethanolamines in the Skin

Miragliotta, V., & Noli, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-68317-7_9 · Cited by 5

Improvement of Topical Palmitoylethanolamide Anti-Inflammatory Activity by Pegylated Prodrugs

Tronino, D., Russo, R., Ostacolo, C., Mazzolari, A., Caro, C. D., Avagliano, C., Laneri, S., Rana, G. L., Sacchi, A., Valle, F. D., et al. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00397 · Cited by 5

Endocannabinoid System

O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_2 · Cited by 4

Oral Supplementation with Ultramicronized Palmitoylethanolamide for Joint Disease and Lameness Management in Four Jumping Horses: A Case Report

Gugliandolo, E., Barbagallo, A., Peritore, A. F., Cuzzocrea, S., & Crupi, R. (2020) · Animals · doi:10.3390/ani10091469 · Cited by 4

Cannabinoid-Alcohol Interactions

Natividad, L. A., Maccioni, P., Parsons, L. H., & Colombo, G. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_14 · Cited by 4

G03 Aliamides modulate skin mast cell degranulation in dogs and cats

Miolo, A., Re, G., Barbero, R., GIORGI, M., Leotta, R. G., Auxilia, S. T., Noli, C., & Abramo, F. (2006) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2006.00765_4.x · Cited by 4

Treatment of Established Chemotherapy-Induced Neuropathy with N-Palmitoylethanolamide: A Randomized, Double-Blind Phase II Pilot Study

Davis, M. P., Ulrich, A., Segal, R. A., Gudena, V. K., Ruddy, K. J., D’Andre, S. D., Giridhar, K. V., Vasireddy, V. K., Agarwal, R., Azzouqa, A., et al. (2024) · Cancers · doi:10.3390/cancers16244244 · Cited by 3

High-Performance Liquid Chromatography with DAD Detection for the Determination of Cannabinoids in Commercial Veterinary CBD Oil

Hajrulai-Musliu, Z., Dimitrieska-Stojkovikj, E., Gusheski, D., Musliu, D., & Velkovski, D. (2024) · Pharmacy · doi:10.3390/pharmacy12060181 · Cited by 3

Transient Receptor Potential Vanilloid 1 Involvement in Animal Pain Perception

Vercelli, C., Barbero, R., & Re, G. (2015) · American Journal of Animal and Veterinary Sciences · doi:10.3844/ajavsp.2015.47.52 · Cited by 3

Chronic Pain and Behavior

Gowan, R. A., & Iff, I. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-7401-2.00015-5 · Cited by 3

Nuclear scintigraphy: Uses and limitations

Dyson, S. (2006) · The Veterinary Journal · doi:10.1016/j.tvjl.2005.12.010 · Cited by 3

Role of Endocannabinoids in Glaucoma: A Review

Dada, T., Angmo, D., Velpandian, T., Venkatraman, V., Warjri, G. B., & Gowtham, L. (2025) · JOURNAL OF CURRENT GLAUCOMA PRACTICE · doi:10.5005/jp-journals-10078-1467 · Cited by 2

Palmitoylethanolamid and Other Lipid Autacoids Against Neuroinflammation, Pain, and Spasms in Multiple Sclerosis

Hesselink, J. M. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805298-3.00004-9 · Cited by 2

Anandamide and Other Acylethanolamides

Petrosino, S., & Marzo, V. D. (2009) · Springer eBooks · doi:10.1007/978-0-387-30378-9_5 · Cited by 2

Antiproliferative Effects of Palmitoylethanolamide on Human Cervical Cancer Cells

Bonfili, L., Cecarini, V., & Eleuteri, A. M. (2019) · International e-Conference on Cancer Research · doi:10.28991/iccr-2019-020 · Cited by 2

Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis

Ying-Ying, Y., & Lin, H.-C. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02244.x · Cited by 2

Neuropharmacology of Animal Pain: A Mechanism-Based Therapeutic Approach

Salvo, A. D. (2014) · Journal of Veterinary Science & Medical Diagnosis · doi:10.4172/2325-9590.1000128 · Cited by 1

Palmitoylethanolamide for Neurological Disorders

Faig‐Martí, J. (2020) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2004076 · Cited by 1

Actualización práctica sobre la palmitoiletanolamida (PEAum) oral en el manejo del dolor crónico. Revisión narrativa

Mateos, R. G., & Aguilar, A. (2023) · Multidisciplinary Pain Journal · doi:10.20986/mpj.2023.1044/2023 · Cited by 1

Marijuana Poisoning in Canines in the Aburrá Valley (Antioquia‐Colombia), 2023‐2024

Marulanda, N. R., Álvarez, J. F. O., Puerta, J. H. L., Peralta, A. M. B., & Corrales, N. U. (2025) · Veterinary Medicine International · doi:10.1155/vmi/4844163 · Cited by 1

Deciphering the interaction between N-palmitoyl-D-glucosamine and the endocannabinoidome

Moriello, A. S., Allarà, M., Iannotti, F. A., Marcolongo, G., Piscitelli, F., Verde, R., Marzo, V. D., & Petrosino, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-07103-5 · Cited by 1

N-Palmitoylethanolamine Administration Ameliorates the Clinical Manifestation and Progression of Experimental Autoimmune Encephalomyelitis in Rodents

Impellizzeri, D., Paola, R. D., Ahmad, A., Crupi, R., Paterniti, I., Campolo, M., Bruschetta, G., Clemente, S., Esposito, E., & Cuzzocrea, S. (2014) · European Journal of Inflammation · doi:10.1177/1721727x1401200216 · Cited by 1

Endocannabinoids and N-acylethanolamines in translational pain research : from monoacylglycerol lipase to muscle pain

Ghafouri, N. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Cannabinoid receptor function in the medial prefrontal cortex

den Boon, F. S. (2013) · UvA-DARE (University of Amsterdam)

n-3 Fatty acid derived endocannabinoids: a new link between fish oil and inflammation

Balvers, M. G. J. (2012) · doi:10.18174/202605

Nutraceuticals for canine osteoarthritis: scientific evidence of an innovative "disease-modifying" approach

Magnani, F. G. (2010)

The Effect of Palmitoylethanolamide Analogue, N-(2-Morpholinoethyl) Palmitoylamide on Pain Behaviour in Mice

Karimi, G., Hadizadeh, F., Mirshamsi, A., & Ziaee, T. (2008)

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Evaluation of the efficacy and Safety of Palmitoylethanolamide (PEA) combination in managing dermatitis in dogs

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FIGURES 45. Axinyssa djiferi spec. nov. 4 in A new species of Axinyssa Lendenfeld, 1897 (Porifera, Demospongiae, Halichondrida) from the Senegalese coast

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Sex-specific differences in nociceptive behaviour and the amygdala endocannabinoid system in the rat monoiodoacetate-induced knee osteoarthritis model

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BindingDB Entry 50031221: Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase.

BindingDB (2010) · UC San Diego · doi:10.7270/q2319w1h

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The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

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