The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Sonodynamic Therapy Combined to 2-Deoxyglucose Potentiate Cell Metastasis Inhibition of Breast Cancer
Abstract
Metastasis is a major dilemma of cancer therapy. It frequently occurs in breast cancer, which is the leading form of malignant tumor among females worldwide. Although there are therapies that provide a possible method for this challenge, such as chemotherapy, the tumoral metabolic pathway is unconventional and favors metastasis and proliferation. This magnifies the difficulty of treating breast cancer. In this study, we identified 2-deoxyglucose (2 DG) as an important glycolysis suppressor that can potentiate sonodynamic therapy (SDT) to inhibit migration and invasion. In addition, disruptions of the cell membrane microstructure were captured by a scanning electron microscope in cells treated with the co-therapy. Similarly, we detected blockages of the cell cycle process, using flow cytometry. Of note, we observed that hexokinase II (HK2), the rate-limiting enzyme of glycolysis, was notably uncoupled from the mitochondria in SDT + 2 DG co-therapy group. Furthermore, there was altered expression of HK2 and Glut1, which control glycolysis. Simultaneously, the in vivo results revealed that pulmonary metastasis was also seriously suppressed by SDT + 2 DG co-therapy. These results demonstrate this co-therapy is a promising strategy for breast cancer inhibition through metastasis and proliferation.
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“A similar combination therapy scheme showed that the growth of primary and lung metastasis of breast cancer was inhibited by blocking cell cycle progression and the expression of the key limiting enzymes hexokinase II (HK2) and glucose transporter 1 (Glut1) in the lycolytic pathway, as well as their coupling with mitochondria (Fig. 10E) [131].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [131]
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Advances and perspectives in organic sonosensitizers for sonodynamic therapy
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Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine
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Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications
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Metadata
- Authors
- Xie, L., Feng, X., Huang, M., Zhang, K., & Liu, Q.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shaanxi Normal University (CN)
- Corresponding author
- Zhang, Kun
- Venue
- Ultrasound in Medicine & Biology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 45
- Issue
- 11
- Pages
- 2984-2992
- ISSN
- 0301-5629 (ISSN-L)
- OpenAlex
- W2967770727
- Cited by
- 17
- References
- 48
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrasound in Medicine & Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571834)
- Fundamental Research Funds for the Central Universities (GK201803043)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Keywords
- sonodynamic therapy, 2-deoxyglucose, breast cancer, metastasis suppression, glycolysis inhibition, hexokinase 2, GLUT1, cell migration and invasion, cell cycle arrest, mitochondrial uncoupling, lung metastasis
- MeSH terms
- Animals, Cell Movement, Cell Survival, Deoxyglucose, Female, Flow Cytometry, Glycolysis, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Microscopy, Electron, Scanning, Neoplasm Metastasis, Ultrasonic Therapy, Cell Line, Tumor, Mice
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