Extraction of natural products using supercritical fluids and pressurized liquids assisted by ultrasound: Current status and trends
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Natural products are a source of a wide range of chemical compounds, from pigments to bioactive compounds, which can be extracted and used in different applications. Due to consumer awareness, the interest in natural compounds significantly increased in the last decades, prompting the search for more efficient and environmentally friendly extraction techniques and methods. Pressurized liquids and fluids (sub and supercritical) are being explored to extract natural compounds within the green process concept. The combination of these techniques with ultrasound has emerged as an alternative to intensify the extraction process efficiently. In this context, this work presents a comprehensive review and current insights into the use of high-pressure systems, specifically supercritical fluid extraction and pressurized liquid extraction assisted by ultrasound, as emerging technologies for extracting bioactive compounds from natural products. The extraction mechanisms, applications, and the influence of operational parameters in the process are addressed, in addition to an analysis of the main challenges to be overcome for widespread application.
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UAE enables efficient extraction of targeted bioactive components by leveraging its distinct cavitation effect.
“UAE enables the efficient extraction of targeted bioactive components by leveraging its distinct cavitation effect.”
From A comprehensive review of ultrasonic assisted extraction (UAE) for bioactive components: Principles, advantages, equipment, and combined technologies (2023) · cites this paper as [8]
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- [102]N. V. Malykh, V.M. Petrov, G. Sankin, On sonocapillary effect, in: 5th World Congr. Ultrason., Paris, 2003: pp. 1343–1346.
Cited by
Sorted by citations
Shen, L., Pang, S., Zhong, M., Sun, Y., Qayum, A., Liu, Y., Rashid, A., Xu, B., Liang, Q., Ma, H., et al. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106646 · Cited by 892 · see citing works
“By employing the UAE, researchers can achieve the dual goals of efficient extraction and sustainable practices in a more environmentally friendly manner [8 – 12].”
Methodda Silva, L. C., Viganó, J., de Souza Mesquita, L. M., Dias, A. L. B., de Souza, M. C., Sanches, V. L., Chaves, J. O., Pizani, R. S., Contieri, L. S., & Rostagno, M. A. (2021) · Food Chemistry: X · doi:10.1016/j.fochx.2021.100133 · Cited by 78 · see citing works
Self-citationSupercritical fluids and fluid mixtures to obtain high-value compounds from Capsicum peppers
De Aguiar, A. C., Viganó, J., da Silva Anthero, A. G., Dias, A. L. B., Hubinger, M. D., & Martínez, J. (2022) · Food Chemistry: X · doi:10.1016/j.fochx.2022.100228 · Cited by 45 · see citing works
Self-citation
- Authors
- Dias, A. L. B., de Aguiar, A. C., & Rostagno, M. A.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Venue
- Ultrasonics Sonochemistry
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 74
- Pages
- 105584
- ISSN
- 1350-4177 (ISSN-L)
- PMC
- PMC8122360
- OpenAlex
- W3157703667
- Cited by
- 174
- References
- 106
- Citations by year
- 2026: 39 · 2025: 39 · 2024: 35 · 2023: 27 · 2022: 25 · 2021: 9
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Ultrasonics Sonochemistry (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- CNPq
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Physical Sciences › Materials Science › Materials Chemistry › Ultrasound and Cavitation Phenomena
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Keywords
- supercritical fluid extraction, accelerated solvent extraction, ultrasound-assisted extraction, natural products, bioactive compounds, green extraction, extraction mechanism, operating conditions, extraction intensification
- MeSH terms
- Biological Products, Pressure, Chromatography, Supercritical Fluid
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