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Vaccination and antigenic drift in influenza
Open accessAbstract
The relationship between influenza antigenic drift and vaccination lies at the intersection of evolutionary biology and public health, and it must be viewed and analyzed in both contexts simultaneously. In this paper, 1 review what is known about the effects of antigenic drift on vaccination and the effects of vaccination on antigenic drift, and I suggest some simple ways to detect the presence of antigenic drift in seasonal influenza data. If antigenic drift occurs on the time scale of a single influenza season, it may be associated with the presence of herd immunity at the beginning of the season and may indicate a need to monitor for vaccine updates at the end of the season. The relationship between antigenic drift and vaccination must also be viewed in the context of the global circulation of influenza strains and the seeding of local and regional epidemics. In the data sets I consider--from New Zealand, New York, and France--antigenic drift can be statistically detected during some seasons, and seeding of epidemics appears to be endogenous sometimes and exogenous at other times. Improved detection of short-term antigenic drift and epidemic seeding would significantly benefit influenza monitoring efforts and vaccine selection.
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“Each pathogen poses a unique set of challenges, including high lethality, rapid mutations, immune evasion, new strains and variants252–258.”
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Metadata
- Authors
- Boni, M. F.
- Affiliations
- Resources For The Future (US)
- Corresponding author
- Boni, Maciej F.
- ORCID
- Boni, Maciej F.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 26
- Pages
- C8-C14
- ISSN
- 0264-410X (ISSN-L)
- PMC
- PMC2603026
- OpenAlex
- W2023224232
- Cited by
- 226
- References
- 48
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 47 · 2020: 19 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 8
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Human Genome Research Institute (F32HG000205, HG000205, P01HG000205)
- National Institute of General Medical Sciences (GM28016, R01GM028016)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- influenza vaccination, seasonal influenza, herd immunity, vaccine update, vaccine selection
- MeSH terms
- Antigenic Variation, Biological Evolution, Humans, Influenza, Human, Influenza Vaccines, Vaccination, Virulence, Genetic Drift, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype
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