Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis
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Vaccines that drive robust T-cell immunity against Mycobacterium tuberculosis (Mtb) are needed both for prophylactic and therapeutic purposes. We have recently developed a synthetic vaccine delivery platform with Pluronic-stabilized polypropylene sulfide nanoparticles (NPs), which target lymphoid tissues by their small size (∼ 30 nm) and which activate the complement cascade by their surface chemistry. Here we conjugated the tuberculosis antigen Ag85B to the NPs (NP-Ag85B) and compared their efficacy in eliciting relevant immune responses in mice after intradermal or pulmonary administration. Pulmonary administration of NP-Ag85B with the adjuvant CpG led to enhanced induction of antigen-specific polyfunctional Th1 responses in the spleen, the lung and lung-draining lymph nodes as compared to soluble Ag85B with CpG and to the intradermally-delivered formulations. Mucosal and systemic Th17 responses were also observed with this adjuvanted NP formulation and vaccination route, especially in the lung. We then evaluated protection induced by the adjuvanted NP formulation following a Mtb aerosol challenge and found that vaccination with NP-Ag85B and CpG via the pulmonary route displayed a substantial reduction of the lung bacterial burden, both compared to soluble Ag85B with CpG and to the corresponding intradermally delivered formulations. These findings highlight the potential of administrating NP-based formulations by the pulmonary route for TB vaccination.
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Pulmonary administration of the common TB antigen 85B conjugated to poly(propylene sulphide) nanoparticles demonstrated improved protection in mice after challenge with aerosolized M. tuberculosis.
“Pulmonary administration of the common TB antigen 85B conjugated to poly(propylene sulphide) nanoparticles demonstrated improved protection in mice after they were challenged with aerosolized M. tuberculosis (ref. 135 ).”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [135]
Cites
Lutz, M. B., Kukutsch, N. A., Ogilvie, A. L. J., Rößner, S., Koch, F., Romani, N., & Schuler, G. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00204-x · Cited by 2,972 · see citing works
Sample criteria for testing outlying observations
Grubbs, F. E. (1950) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177729885 · Cited by 1,631 · see citing works
Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel‐Moreno, J., Cilley, G. E., Shen, F., Eaton, S. M., Gaffen, S. L., Swain, S. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1449 · Cited by 1,442 · see citing works
Exploiting lymphatic transport and complement activation in nanoparticle vaccines
Reddy, S. T., van der Vlies, A. J., Simeoni, E., Angeli, V., Randolph, G. J., O’Neil, C. P., Lee, L. K., Swartz, M. A., & Hubbell, J. A. (2007) · Nature Biotechnology · doi:10.1038/nbt1332 · Cited by 1,355 · see citing works
Self-citationGlobal tuberculosis control 2010
Behera, D. (2012) · The Indian Journal of Medical Research · Cited by 1,262 · see citing works
Induction and effector functions of TH17 cells
Bettelli, E., Korn, T., Oukka, M., & Kuchroo, V. K. (2008) · Nature · doi:10.1038/nature07036 · Cited by 1,207 · see citing works
The success and failure of BCG — implications for a novel tuberculosis vaccine
Andersen, P. L., & Doherty, T. M. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1211 · Cited by 791 · see citing works
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685 · see citing works
Self-citationMaterials engineering for immunomodulation
Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009) · Nature · doi:10.1038/nature08604 · Cited by 565 · see citing works
Self-citationUptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
Sharp, F. A., Ruane, D., Claass, B., Creagh, E. M., Harris, J., Malyala, P., Singh, M., O’Hagan, D. T., Pétrilli, V., Tschopp, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804897106 · Cited by 536 · see citing works
Scriba, T. J., Kalsdorf, B., Abrahams, D. A., Isaacs, F., Hofmeister, J., Black, G. F., Hassan, H. Y., Wilkinson, R. J., Walzl, G., Gelderbloem, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1962 · Cited by 410 · see citing works
Inflammasomes: current understanding and open questions
Bauernfeind, F. G., Ablasser, A., Bartok, E., Kim-Hellmuth, S., Schmid-Burgk, J. L., Cavlar, T., & Hornung, V. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0567-4 · Cited by 356 · see citing works
IL-17 and Th17 cells in tuberculosis
Torrado, E., & Cooper, A. M. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.004 · Cited by 327 · see citing works
Forbes, E. K., Sander, C., Ronan, E. O., McShane, H., Hill, A., Beverley, P., & Tchilian, E. (2008) · Journal of Immunology · doi:10.4049/jimmunol.181.7.4955 · Cited by 307 · see citing works
Kaufmann, S. H. E., Hussey, G. D., & Lambert, P. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60393-5 · Cited by 297 · see citing works
Mittrücker, H., Steinhoff, U., Köhler, A. C., Krause, M., Lazar, D., Mex, P., Miekley, D., & Kaufmann, S. H. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703510104 · Cited by 283 · see citing works
Hirosue, S., Kourtis, I. C., van der Vlies, A. J., Hubbell, J. A., & Swartz, M. A. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.09.077 · Cited by 234 · see citing works
Self-citationIL-17–producing T cells in lung immunity and inflammation
Nembrini, C., Marsland, B. J., & Köpf, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.033 · Cited by 210 · see citing works
Self-citationScriba, T. J., Tameris, M. D., Mansoor, N., Smit, E., van der Merwe, L., Isaacs, F., Keyser, A. T., Moyo, S., Brittain, N. J., Lawrie, A. M., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200939754 · Cited by 190 · see citing works
CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
Klinman, D. M., Klaschik, S., Sato, T., & Tross, D. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.12.012 · Cited by 181 · see citing works
Single step protocol to purify recombinant proteins with low endotoxin contents
Reichelt, P., Schwarz, C., & Donzeau, M. (2005) · Protein Expression and Purification · doi:10.1016/j.pep.2005.09.027 · Cited by 166 · see citing works
Nanobead-based interventions for the treatment and prevention of tuberculosis
Griffiths, G., Nyström, B., Sable, S. B., & Khuller, G. K. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2437 · Cited by 164 · see citing works
Engineering complement activation on polypropylene sulfide vaccine nanoparticles
Thomas, S. N., van der Vlies, A. J., O’Neil, C. P., Reddy, S. T., Yu, S. S., Giorgio, T. D., Swartz, M. A., & Hubbell, J. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.037 · Cited by 127 · see citing works
Self-citationvan der Vlies, A. J., O’Neil, C. P., Hasegawa, U., Hammond, N. A., & Hubbell, J. A. (2010) · Bioconjugate Chemistry · doi:10.1021/bc9004443 · Cited by 111 · see citing works
Self-citationIntranasal Immunization Promotes Th17 Immune Responses
Zygmunt, B. M., Rharbaoui, F., Groebe, L., & Guzmán, C. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901144 · Cited by 88 · see citing works
A key role for lung‐resident memory lymphocytes in protective immune responses after BCG vaccination
Connor, L. M., Harvie, M., Rich, F. J., Quinn, K. M., Brinkmann, V., Gros, G. S. L., & Kirman, J. R. (2010) · European Journal of Immunology · doi:10.1002/eji.200940279 · Cited by 76 · see citing works
Stano, A., van der Vlies, A. J., Martino, M. M., Swartz, M. A., Hubbell, J. A., & Simeoni, E. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.11.010 · Cited by 73 · see citing works
Self-citationLakey, D. L., Voladri, R. K. R., Edwards, K. M., Hager, C., Samten, B., Wallis, R. S., Barnes, P. F., & Kernodle, D. S. (2000) · Infection and Immunity · doi:10.1128/iai.68.1.233-238.2000 · Cited by 67 · see citing works
Should a new tuberculosis vaccine be administered intranasally?
Källenius, G., Pawlowski, A., Brandtzæg, P., & Svenson, S. B. (2007) · Tuberculosis · doi:10.1016/j.tube.2006.12.006 · Cited by 60 · see citing works
Benwell, R. K., & Lee, D. R. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.09.013 · Cited by 60 · see citing works
Vaccine strategies against tuberculosis
McShane, H. (2009) · Swiss Medical Weekly · doi:10.4414/smw.2009.12374 · Cited by 34 · see citing works
Prospects for a new, safer and more effective TB vaccine
Hawkridge, T., & Mahomed, H. (2010) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2010.09.013 · Cited by 32 · see citing works
Application of an electronic counter in the evaluation of significant bacteriuria.
Jp, T., Wa, B., & Ke, M. (1962) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
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Sorted by citations
From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
Trevaskis, N. L., Kaminskas, L. M., & Porter, C. J. H. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4608 · Cited by 654 · see citing works
Engineering synthetic vaccines using cues from natural immunity
Irvine, D. J., Swartz, M. A., & Szeto, G. L. (2013) · Nature Materials · doi:10.1038/nmat3775 · Cited by 596 · see citing works
Self-citationNanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Nanoparticle Vaccines Against Infectious Diseases
Pati, R., Shevtsov, M. A., & Sonawane, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02224 · Cited by 515 · see citing works
Nanoparticle diffusion in respiratory mucus from humans without lung disease
Schuster, B. S., Suk, J. S., Woodworth, G. F., & Hanes, J. S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.064 · Cited by 468 · see citing works
Nanotechnology for COVID-19: Therapeutics and Vaccine Research
Chauhan, G., Madou, M. J., Kalra, S., Chopra, V., Ghosh, D., & Martinez-Chapa, S. O. (2020) · ACS Nano · doi:10.1021/acsnano.0c04006 · Cited by 382 · see citing works
COVID-19 vaccines: The status and perspectives in delivery points of view
Chung, J. Y., Thone, M. N., & Kwon, Y. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.011 · Cited by 375 · see citing works
Thomas, S. N., Vokali, E., Lund, A. W., Hubbell, J. A., & Swartz, M. A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.003 · Cited by 310 · see citing works
Self-citationImmunological properties of gold nanoparticles
Dykman, L. A., & Khlebtsov, N. G. (2016) · Chemical Science · doi:10.1039/c6sc03631g · Cited by 261 · see citing works
de Titta, A., Ballester, M. C., Julier, Z., Nembrini, C., Jeanbart, L., van der Vlies, A. J., Swartz, M. A., & Hubbell, J. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313152110 · Cited by 254 · see citing works
Self-citationEngineering Approaches to Immunotherapy
Swartz, M. A., Hirosue, S., & Hubbell, J. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003763 · Cited by 223 · see citing works
Self-citationLi, A. V., Moon, J. J., Abraham, W. D., Suh, H., Elkhader, J. A., Seidman, M. A., Yen, M., Im, E., Foley, M. H., Barouch, D. H., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006516 · Cited by 187 · see citing works
Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination
Lewinsohn, D. A., Lewinsohn, D. M., & Scriba, T. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01262 · Cited by 176 · see citing works
New perspectives in nanomedicine
Thorley, A. J., & Tetley, T. D. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.06.008 · Cited by 171 · see citing works
Biomaterial Strategies for Immunomodulation
Hotaling, N. A., Tang, L., Irvine, D. J., & Babensee, J. E. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104814 · Cited by 170 · see citing works
Applications of nanomaterials as vaccine adjuvants
Zhu, M., Wang, R., & Nie, G. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.29589 · Cited by 162 · see citing works
Knight, F. C., Gilchuk, P., Kumar, A., Becker, K. W., Sevimli, S., Jacobson, M. E., Suryadevara, N., Wang-Bishop, L., Boyd, K., Crowe, J., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00326 · Cited by 113 · see citing works
Kourtis, I. C., Hirosue, S., de Titta, A., Kontos, S., Stegmann, T., Hubbell, J. A., & Swartz, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061646 · Cited by 127 · see citing works
Self-citationSynthetic nanovaccines for immunotherapy
Luo, M., Samandi, L. Z., Wang, Z., Chen, Z. J., & Gao, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.033 · Cited by 124 · see citing works
Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles
Stano, A., Scott, E. A., Dane, K. Y., Swartz, M. A., & Hubbell, J. A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.024 · Cited by 119 · see citing works
Self-citationLin, L. C. W., Chattopadhyay, S., Lin, J., & Hu, C. J. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701395 · Cited by 108 · see citing works
Nanocarriers Targeting Dendritic Cells for Pulmonary Vaccine Delivery
Kunda, N. K., Somavarapu, S., Gordon, S. B., Hutcheon, G. A., & Saleem, I. Y. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0891-5 · Cited by 98 · see citing works
Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy
Thomas, S. N., Rohner, N. A., & Edwards, E. E. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-101515-014413 · Cited by 84 · see citing works
Stano, A., Nembrini, C., Swartz, M. A., Hubbell, J. A., & Simeoni, E. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.10.050 · Cited by 84 · see citing works
Self-citationRashidzadeh, H., Danafar, H., Rahimi, H., Mozafari, F., Salehiabar, M., Rahmati, M.-A., Rahamouz-Haghighi, S., Mousazadeh, N., Mohammadi, A., Ertaş, Y. N., et al. (2021) · Nanomedicine · doi:10.2217/nnm-2020-0441 · Cited by 76 · see citing works
Bo, R., Sun, Y., Zhou, S., Ou, N., Gu, P., Liu, Z., Hu, Y., Liu, J., & Wang, D. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s136820 · Cited by 72 · see citing works
Design of nanomaterial based systems for novel vaccine development
Liu, Y., Li, W., Kirberger, M., Liao, W., & Ren, J. (2016) · Biomaterials Science · doi:10.1039/c5bm00507h · Cited by 70 · see citing works
How can nanoparticles contribute to antituberculosis therapy?
Costa-Gouveia, J., Aínsa, J. A., Brodin, P. M., & Lucía, A. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.01.011 · Cited by 68 · see citing works
Devices and formulations for pulmonary vaccination
Tonnis, W. F., Lexmond, A. J., Frijlink, H. W., de Boer, A. H., & Hinrichs, W. L. J. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.810622 · Cited by 66 · see citing works
Airway delivery of peptides and proteins using nanoparticles
Dombu, C. Y., & Betbeder, D. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.070 · Cited by 64 · see citing works
Vrieze, J. D., Louage, B., Deswarte, K., Zhong, Z., Coen, R. D., Herck, S. V., Nuhn, L., Frich, C. K., Zelikin, A. N., Lienenklaus, S., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201905687 · Cited by 64 · see citing works
Biomaterials Strategies for Generating Therapeutic Immune Responses
Kelly, S. H., Shores, L. S., Votaw, N. L., & Collier, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.009 · Cited by 51 · see citing works
Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates
Agger, E. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.012 · Cited by 60 · see citing works
Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges
Stylianou, E., Paul, M. J., Reljić, R., & McShane, H. (2019) · Expert Review of Vaccines · doi:10.1080/14760584.2019.1692657 · Cited by 59 · see citing works
The expanding role of aerosols in systemic drug delivery, gene therapy and vaccination: an update
Laube, B. L. (2014) · Translational Respiratory Medicine · doi:10.1186/2213-0802-2-3 · Cited by 58 · see citing works
Rincón-Restrepo, M., Mayer, A. T., Hauert, S., Bonner, D. K., Phelps, E. A., Hubbell, J. A., Swartz, M. A., & Hirosue, S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.047 · Cited by 55 · see citing works
Self-citationRodrigues, T. C., Oliveira, M. L. S., Schanoski, A. S., Rico, S. L. C., Poschinger-Figueiredo, D., Gonçalves, V. M., Ferreira, D. M., Kunda, N. K., Saleem, I. Y., & Miyaji, E. N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191692 · Cited by 55 · see citing works
Pulmonary Vaccine Delivery: A Realistic Approach?
Tonnis, W. F., Kersten, G. F. A., Frijlink, H. W., Hinrichs, W. L. J., de Boer, A. H., & Amorij, J. (2012) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2011.0931 · Cited by 54 · see citing works
Ballester, M. C., Jeanbart, L., de Titta, A., Nembrini, C., Marsland, B. J., Hubbell, J. A., & Swartz, M. A. (2015) · Scientific Reports · doi:10.1038/srep14274 · Cited by 49 · see citing works
Self-citationA high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening
Garcia-Cordero, J. L., Nembrini, C., Stano, A., Hubbell, J. A., & Maerkl, S. J. (2013) · Integrative Biology · doi:10.1039/c3ib20263a · Cited by 48 · see citing works
Self-citationAerosol pulmonary immune engineering
Sudduth, E. R., Trautmann-Rodriguez, M., Gill, N. A., Bomb, K., & Fromen, C. A. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114831 · Cited by 49 · see citing works
Carrier molecules for use in veterinary vaccines
Gerdts, V., Mutwiri, G., Richards, J. M., den Hurk, S. V. D. L., & Potter, A. A. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.11.067 · Cited by 44 · see citing works
Targeted immunomodulation using antigen‐conjugated nanoparticles
McCarthy, D. P., Hunter, Z. N., Chackerian, B., Shea, L. D., & Miller, S. D. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1263 · Cited by 45 · see citing works
Roles of Mucosal Immunity againstMycobacterium tuberculosisInfection
Li, W., Deng, G., Li, M., Liu, X., & Wang, Y. (2012) · Tuberculosis Research and Treatment · doi:10.1155/2012/791728 · Cited by 43 · see citing works
Nanomaterials in the Prevention, Diagnosis, and Treatment of Mycobacterium Tuberculosis Infections
Xu, K., Liang, Z. C., Ding, X., Hu, H., Liu, S., Nurmik, M., Bi, S., Hu, F.-S., Ji, Z., Ren, J., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700509 · Cited by 44 · see citing works
Eby, J. K., Dane, K. Y., O’Neil, C. P., Hirosue, S., Swartz, M. A., & Hubbell, J. A. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.007 · Cited by 40 · see citing works
Self-citationKabiri, M., Sankian, M., Sadri, K., & Tafaghodi, M. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.11.003 · Cited by 38 · see citing works
Galliverti, G., Tichet, M., Domingos‐Pereira, S., Hauert, S., Nardelli‐Haefliger, D., Swartz, M. A., Hanahan, D., & Wullschleger, S. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0166 · Cited by 36 · see citing works
Self-citationLi, W., Deng, G., Li, M., Jin, Z., Zhao, L., Liu, X., & Wang, Y. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.007 · Cited by 35 · see citing works
Nesamony, J., Shah, I. S., Kalra, A. V., & Jung, R. (2013) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2013.814065 · Cited by 35 · see citing works
Chesson, C. B., Huante, M. B., Nusbaum, R. J., Walker, A. G., Clover, T. M., Jagannath, C., Endsley, J. J., & Rudra, J. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31089-y · Cited by 35 · see citing works
Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Sato, T., Shimosato, T., Ueda, A., Ishigatsubo, Y., & Klinman, D. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0401 · Cited by 28 · see citing works
Xu, L., Cui, G., Jia, H., Zhu, Y., Ding, Y., Chen, J., Lu, C., Ye, P., Gao, H., Li, L., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0909-6 · Cited by 34 · see citing works
Mucosal Vaccines: Where Do We Stand?
Kraehenbühl, J.-P., & Neutra, M. R. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113136660186 · Cited by 34 · see citing works
HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis
Verwaerde, C., Debrie, A., Dombu, C. Y., Legrand, D., Raze, D., Lecher, S., Betbeder, D., & Locht, C. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.09.024 · Cited by 32 · see citing works
Bekale, R. B., du Plessis, S., Hsu, N., Sharma, J. R., Sampson, S. L., Jacobs, M., Meyer, M., Morse, G. D., & Dube, A. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2528-9 · Cited by 32 · see citing works
Todoroff, J., Učakar, B., Inglese, M., Vandermarliere, S., Fillée, C., Renauld, J., Huygen, K., & Rita Vanbever, A. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.11.020 · Cited by 31 · see citing works
Potential of nanotechnology as a delivery platform against tuberculosis: Current research review
Choudhary, S., & Devi, V. K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.01.035 · Cited by 28 · see citing works
Flórido, M., Pillay, R., Gillis, C. M., Xia, Y., Turner, S. J., Triccas, J. A., Stambas, J., & Britton, W. J. (2014) · European Journal of Immunology · doi:10.1002/eji.201444954 · Cited by 28 · see citing works
Khademi, F., Derakhshan, M., Avarvand, A. Y., & Tafaghodi, M. (2018) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.22059.5648 · Cited by 28 · see citing works
Ou, B. S., Baillet, J., Picece, V. C. T. M., Gale, E. C., Powell, A. E., Saouaf, O. M., Yan, J., Nejatfard, A., Hernandez, H. L., & Appel, E. A. (2024) · ACS Nano · doi:10.1021/acsnano.3c09700 · Cited by 27 · see citing works
Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
Montalvo-Quirós, S., Vallet‐Regí, M., Palacios, A., Anguíta, J., Prados‐Rosales, R., González, B., & Luque-Garcia, J. L. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121218 · Cited by 24 · see citing works
Engineering Vaccines for Tissue-Resident Memory T Cells
Knight, F. C., & Wilson, J. T. (2021) · Advances in Therapy · doi:10.1002/adtp.202000230 · Cited by 22 · see citing works
Development of novel carrier(s) mediated tuberculosis vaccine: More than a tour de force
Garg, N. K., Dwivedi, P., Jain, A., Tyagi, S., Sahu, T., & Tyagi, R. K. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.05.028 · Cited by 23 · see citing works
Watanabe, K., Matsubara, A., Kawano, M., Mizuno, S., Okamura, T., Tsujimura, Y., Inada, H., Nosaka, T., Matsuo, K., & Yasutomi, Y. (2014) · Vaccine · doi:10.1016/j.vaccine.2013.11.108 · Cited by 23 · see citing works
Sankhe, K., Khan, T., Bhavsar, C., Momin, M., & Omri, A. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1609937 · Cited by 18 · see citing works
Nanotoxoids: Biomimetic Nanoparticle Vaccines against Infections
Guo, Z., Kubiatowicz, L. J., Fang, R. H., & Zhang, L. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100072 · Cited by 22 · see citing works
Brubaker, C. E., Panagiotou, V., Demurtas, D., Bonner, D. K., Swartz, M. A., & Hubbell, J. A. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00456 · Cited by 20 · see citing works
Self-citationAdvancements in Nanoparticle-Based Adjuvants for Enhanced Tuberculosis Vaccination: A Review
Wang, J., Zhao, Z., Wang, Q., Shi, J., Wong, D. W., & Cheung, J. C. (2024) · Vaccines · doi:10.3390/vaccines12121335 · Cited by 19 · see citing works
Nanocarriers for Respiratory Diseases Treatment: Recent Advances and Current Challenges
Trapani, A., Gioia, S. D., Castellani, S., Carbone, A., Cavallaro, G., Trapani, G., & Conese, M. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026614666140329225817 · Cited by 19 · see citing works
Sharma, A., Sharma, V., Sharma, S., Sharma, S., Sharma, M., & Sivanesan, I. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111459 · Cited by 16 · see citing works
Pradhan, B., Guha, D., Murmu, K. C., Sur, A., Ray, P., Das, D., & Aich, P. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0278-1 · Cited by 16 · see citing works
Sharma, D. K. (2025) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2025.107138 · Cited by 15 · see citing works
Advancing Immunotherapeutic Vaccine Strategies Against Pulmonary Tuberculosis
Afkhami, S., Villela, A. D., D’Agostino, M. R., Jeyanathan, M., Gillgrass, A. E., & Xing, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.557809 · Cited by 15 · see citing works
Morgun, E., Zhu, J. Y., Almunif, S., Bobbala, S. K. R., Aguilar, M. S., Wang, J., Conner, K., Cui, Y., Cao, L., Seshadri, C., et al. (2023) · eLife · doi:10.7554/elife.87431 · Cited by 14 · see citing works
In vivo imaging of T cells loaded with gold nanoparticles: a pilot study
Li, H., Diaz, L., Lee, D. Y., Cui, L., Liang, X., & Cheng, Y. (2013) · La radiologia medica · doi:10.1007/s11547-013-0335-2 · Cited by 14 · see citing works
Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung
Kim, Y. C., Hsueh, H. T., Kim, N., Rodriguez, J., Leo, K. T., Rao, D., West, N. E., Hanes, J. S., & Suk, J. S. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000228 · Cited by 12 · see citing works
A comprehensive review on efficient approaches for combating coronaviruses
Pouresmaieli, M., Ekrami, E., Akbari, A., Noorbakhsh, N., Moghadam, N. B., & Mamoudifard, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112353 · Cited by 12 · see citing works
Development of a New Tuberculosis Vaccine: Is there Value in the Mucosal Approach?
Diogo, G. R., & Reljić, R. (2014) · Immunotherapy · doi:10.2217/imt.14.62 · Cited by 11 · see citing works
Li, A., Cai, X., Li, D., Yu, Y., Liu, C., Shen, J., You, J., Qiao, J., & Wang, F. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s479741 · Cited by 10 · see citing works
Transgene Delivery to Human Induced Pluripotent Stem Cells Using Nanoparticles
Yamoah, M., Thai, P. N., & Zhang, X.-D. (2021) · Pharmaceuticals · doi:10.3390/ph14040334 · Cited by 10 · see citing works
Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung
Kim, Y. C., Hsueh, H. T., Kim, N., Rodriguez, J., Leo, K. T., Rao, D., West, N. E., Hanes, J. S., & Suk, J. S. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000013 · Cited by 9 · see citing works
Genta, I., Colonna, C., Conti, B., Caliceti, P., Salmaso, S., Speziale, P., Pietrocola, G., Chiesa, E., Modena, T., & Dorati, R. (2016) · Journal of Microencapsulation · doi:10.1080/02652048.2016.1260661 · Cited by 9 · see citing works
Novel Nanotechnology Based Delivery Systems for Chemotherapy and Prophylaxis of Tuberculosis
Jain, R., Savla, H. M., Naik, I., Maniar, J., Punjabi, K., Vaidya, S. P., & Menon, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813351-4.00034-1 · Cited by 9 · see citing works
Correlates of Protection from Tuberculosis
Álvarez, M. P. P., Marshall, J. L., & Tanner, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-24355-4_6 · Cited by 8 · see citing works
Gold nanoparticle-based strategies against SARS-CoV-2: A review
Rasmi, Y., Kırboğa, K. K., Khan, J., Gupta, E., Attia, F. M., Yallapu, M. M., & Pilaquinga, F. (2023) · REVIEWS ON ADVANCED MATERIALS SCIENCE · doi:10.1515/rams-2023-0105 · Cited by 8 · see citing works
Tuberculosis vaccine developments and efficient delivery systems: A comprehensive appraisal
Hosseinpour, R., Hasani, A., Baradaran, B., Abdolalizadeh, J., Salehi, R., Hasani, A., Nabizadeh, E., Yekani, M., Hasani, R., Kafil, H. S., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26193 · Cited by 8 · see citing works
Development of Adjuvanted Solid Fat Nanoemulsions for Pulmonary Hepatitis B Vaccination
Minz, S., & Pandey, R. S. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.02.007 · Cited by 7 · see citing works
Considerations for the Human Health Implications of Nanotheranostics
Burgum, M. J., Evans, S. J., Jenkins, G. J. S., Doak, S. H., & Clift, M. J. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813339-2.00010-4 · Cited by 6 · see citing works
Nanoparticle Vaccines Against Infectious Diseases
(2020) · Frontiers research topics · doi:10.3389/978-2-88963-327-2 · Cited by 6 · see citing works
Pulmonary Administration of Subunit Vaccines
Tonnis, W. F., Huckriede, A. L. W., Hinrichs, W. L. J., & Frijlink, H. W. (2014) · Advances in delivery science and technology · doi:10.1007/978-1-4939-1417-3_16 · Cited by 5 · see citing works
Vrieze, J. D., Louage, B., Deswarte, K., Zhong, Z., Coen, R. D., Herck, S. V., Nuhn, L., Frich, C. K., Zelikin, A. N., Lienenklaus, S., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201905687 · Cited by 5 · see citing works
Intranasal delivery of nanoparticle-based vaccine increases protection against S. pneumoniae
Mott, B., Thamake, S. I., Vishwanatha, J. K., & Jones, H. P. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-1646-x · Cited by 5 · see citing works
Taniguchi, K., Takii, T., Yamamoto, S., Maeyama, J., Iho, S., Maruyama, M., Iizuka, N., Ozeki, Y., Matsumoto, S., Hasegawa, T., et al. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-25 · Cited by 5 · see citing works
Goals and strategies in vaccine development against tuberculosis
Konjengbam, B. D., Meitei, H. N., Pandey, A., & Haobam, R. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.04.016 · Cited by 4 · see citing works
Pulmonary Delivery of Biopharmaceuticals
Andrade, F., Moura, C. C., & Sarmento, B. F. C. C. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9524-6_7 · Cited by 4 · see citing works
Nanomedicine at the Pulmonary Frontier: Immune-Centric Approaches for Respiratory Disease Treatment
Kaur, J. K., Sharma, A., Passi, G., Dey, P., Khajuria, A., Alajangi, H. K., Jaiswal, P. K., Barnwal, R. P., & Singh, G. (2024) · Immunological Investigations · doi:10.1080/08820139.2023.2298398 · Cited by 3 · see citing works
Nanotechnology laying new foundations for combating COVID-19 pandemic
Jain, S., Hussain, A., Bhatt, A., Nasa, A., Navani, N. K., & Mutreja, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90538-1.00019-4 · Cited by 3 · see citing works
Novel vaccination strategies and approaches against human tuberculosis
Méndez‐Samperio, P. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12774 · Cited by 3 · see citing works
Price, D. N., Kunda, N. K., McBride, A. A., & Muttil, P. (2016) · doi:10.1002/9781118943182.ch4 · Cited by 3 · see citing works
- Authors
- Ballester, M., Nembrini, C., Dhar, N., de Titta, A., de Piano, C., Pasquier, M., Simeoni, E., van der Vlies, A. J., McKinney, J. D., Hubbell, J. A., & Swartz, M. A.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Hubbell, Jeffrey A.
- Swartz, Melody A.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 29
- Issue
- 40
- Pages
- 6959-6966
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W1967877494
- Cited by
- 130
- References
- 33
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 1 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 13 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 15 · 2013: 16 · 2012: 10
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Bill and Melinda Gates Foundation
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- tuberculosis vaccination, Ag85B, CpG adjuvant, nanoparticle conjugation, Th1 response, Th17 response, Mycobacterium tuberculosis, aerosol challenge, lung bacterial burden, complement activation
- MeSH terms
- Acyltransferases, Animals, Antigens, Bacterial, Bacterial Proteins, Complement System Proteins, Dendritic Cells, Lung, Lymph Nodes, Mice, Inbred C57BL, Mycobacterium tuberculosis, Particle Size, Polypropylenes, Spleen, Tuberculosis, Vaccines, Synthetic, Th1 Cells, Immunoconjugates, CpG Islands, Tuberculosis Vaccines, Mice, Nanoparticles, Th17 Cells
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