The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Guillain-Barre syndrome and influenza vaccines: a meta-analysis.
Abstract
Cases of Guillain-Barré syndrome (GBS) have been occasionally associated with influenza vaccines; this possible risk, even if rare, is a matter of much concern. To investigate the strength of this association, a systematic review and a meta-analysis have been conducted; for the purpose, controlled observational studies addressing the risk of GBS associated with different influenza vaccines were sought. We finally selected 39 studies of interest published between 1981 and 2014 (seasonal influenza vaccines, 22; pandemic influenza vaccines, 16; both vaccines simultaneously administered, 1); funnel plot did not identify publication bias. At the association between any influenza vaccine - whether seasonal or pandemic - with GBS, the overall relative risk was 1.41 (95% CI, 1.20-1.66). Pandemic vaccines presented a higher risk (RR=1.84; 95% CI, 1.36-2.50) compared to seasonal vaccines (RR=1.22; 95% CI, 1.01-1.48); the latter should be considered as marginally statistically significant. Pandemic adjuvanted vaccines were not found to be related to a higher risk compared to non-adjuvanted vaccines. The results of the present meta-analysis point to a small but statistically significant association between influenza vaccines, particularly the pandemic ones, and GBS, which is consistent with current explanations upon possible mechanisms for this condition to appear.
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“A metanalysis of 39 controlled observational studies found that the relative risk of GBS following receipt of any influenza vaccine was 1.41 (Martin Arias et al., 2015).”
From Vaccine Safety: Myths and Misinformation (2020) · cites this paper as Martin Arias et al., 2015
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Cites
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Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Walter, E. B., Fry, A. M., & Jernigan, D. B. (2018) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6703a1 · Cited by 1,640
Prevention and Control of Seasonal Influenza with Vaccines
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Olsen, S. J., Karron, R. A., Jernigan, D. B., & Bresee, J. (2016) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6505a1 · Cited by 602
Vaccine Safety: Myths and Misinformation
Geoghegan, S., O’Callaghan, K. P., & Offit, P. A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00372 · Cited by 275
van Doorn, P. A., den Bergh, P. Y. K. V., Hadden, R. D. M., Avau, B., Vankrunkelsven, P., Attarian, S., Blomkwist‐Markens, P. H., Cornblath, D. R., Goedee, H. S., Harbo, T., et al. (2023) · European Journal of Neurology · doi:10.1111/ene.16073 · Cited by 261
Kieseier, B. C., Mathey, E. K., Sommer, C., & Hartung, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0027-2 · Cited by 155
Metadata
- Authors
- Martín Arias, L. H., Sanz, R., Sáinz, M., Treceño, C., & Carvajal, A.
- Affiliations
- Universidad de Valladolid (ES)
- Corresponding author
- Carvajal, A.
- ORCID
- Carvajal, A.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 33
- Issue
- 31
- Pages
- 3773-3778
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W324672716
- Cited by
- 132
- References
- 54
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 28 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 8 · 2016: 6
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- Guillain-Barré syndrome, influenza vaccination, vaccine adverse events, pandemic influenza vaccine, seasonal influenza vaccine, adjuvanted vaccine, relative risk, vaccine safety
- MeSH terms
- Influenza Vaccines, Guillain-Barre Syndrome, Observational Studies as Topic
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