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Cited by 83Hepatitis Viruses Studies and EpidemiologyHepatitis B Virus StudiesViral Infections and Immunology Research

Long-term antibody persistence after vaccination with a 2-dose Havrix™ (inactivated hepatitis A vaccine): 20 years of observed data, and long-term model-based predictions

Open access
Theeten, Heidi, Van Herck, Koen, Van Der Meeren, Olivier, Crasta, Priya, Van Damme, Pierre, Hens, Niel·2015·Vaccine
DOI 10.1016/j.vaccine.2015.07.008
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Abstract

Antibody persistence in two cohorts of adults, who received inactivated hepatitis A (HAV) vaccine (1440El.U; Havrix; GSK Vaccines) according to a 0-6 or 0-12 month schedule in 1992-1993, has been measured annually. After 20 years, >97% of the subjects in both studies were seropositive for anti-HAV antibodies. Geometric mean concentrations in the according-to-protocol cohorts were 312 mIU/ml in 34/36 subjects vaccinated initially at 0-6 months (NCT00289757) and 317 mIU/ml in 85/86 subjects vaccinated at 0-12 months (NCT00291876). Over the whole follow-up period, seven subjects (2+5, respectively) lost circulating anti-HAV antibodies but mounted a strong response after HAV booster administration (1440El.U). Mathematical modelling, which was applied to assess true persistence at Year 20 (accounting for drop-outs and missing data), and to predict longer-term persistence confirmed previous estimates that seropositive anti-HAV levels would persist in ≥95% vaccinees at Year 30 and ≥90% at Year 40. ClinicalTrials.Gov number: NCT00289757/NCT00291876.

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  • Anti-HAV persistence of >20 years was demonstrated among immunocompetent adults vaccinated with a 2-dose hepatitis A schedule as adults.

    “Anti-HAV persistence of >20 years was demonstrated among immunocompetent adults vaccinated with a 2-dose hepatitis A schedule as adults (1303,1305).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1303]

    The Methods describe two-dose vaccination of healthy HAV-naïve adults, and the Results (section 3.1; page unavailable) document anti-HAV antibodies at Year 20. The paper does not demonstrate persistence beyond 20 years by observation: the Discussion (section 4; page unavailable) distinguishes its 20-year follow-up from model-based predictions for later years. (LLM, conf=0.89)

    Experimental — accuracy not yet measured

  • Kinetic models of antibody decrease among adults indicate that protective levels persist for >40 years.

    “Kinetic models of antibody decrease among adults indicate that protective levels persist for >40 years (1302–1304).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1303]

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Research works printed but not linked: 2

  1. Van Herck K, Beutels P, Van Damme P, Beutels M, Van den Dries J, Briantais P, et al. Mathematical models for assessment of long-term persistence of anti- bodies after vaccination with two inactivated hepatitis A vaccines. J Med Virol 2000;60:1-7.
  2. Van Herck K, Van Damme P. Inactivated hepatitis A vaccine-induced antibod- ies: follow-up and estimates of long-term persistence. J Med Virol 2001;63: 1-7.

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Authors
Theeten, H., Van Herck, K., Van Der Meeren, O., Crasta, P., Van Damme, P., & Hens, N.
Affiliations
  • University of Antwerp (BE)
  • GlaxoSmithKline (Belgium) (BE)
ORCID
Venue
Vaccine
Publisher
Elsevier BV
Published
2015-10
Volume
33
Issue
42
Pages
5723-5727
ISSN
0264-410X (ISSN-L)
DOI
10.1016/j.vaccine.2015.07.008
OpenAlex
W918737270
Cited by
82
References
16
Citations by year
2026: 6 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 4 · 2015: 1
FWCI
4.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Vaccine (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
  • Document Server@UHasselt (UHasselt) (submittedVersion, cc-by-nc-nd)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Keywords
hepatitis A vaccine, inactivated hepatitis A vaccine, antibody persistence, anti-HAV antibodies, booster vaccination
MeSH terms
Adult, Double-Blind Method, Female, Follow-Up Studies, Hepatitis A, Humans, Immunization, Secondary, Male, Middle Aged, Vaccination, Vaccines, Inactivated, Linear Models, Hepatitis A Vaccines, Hepatitis A Antibodies

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