Diphtheria vaccine: WHO position paper, August 2017 – Recommendations
Abstract
This article presents the World Health Organization's (WHO) recommendations on the use of diphtheria vaccines excerpted from the Diphtheria vaccines: WHO position paper, August 2017, published in the Weekly Epidemiological Record (Diphtheria vaccine, 2017) [1]. This position paper replaces the 2006 WHO position paper on diphtheria vaccine (Diphtheria vaccine, 2006) [2]. The position paper incorporates recent evidence on diphtheria and provides revised recommendations on the optimal number of doses and timing of diphtheria vaccination. In view of the widespread use of combination vaccines, it provides guidance on the alignment of vaccination schedules for different antigens included in routine childhood immunization programmes. Footnotes to this paper provide a number of core references including references to grading tables that assess the quality of the scientific evidence, and to the evidence-to-recommendation table. In accordance with its mandate to provide guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations of vaccines against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; they summarize essential background information on diseases and vaccines, and conclude with WHO's current position on the use of vaccines in the global context. Recommendations on the use of diphtheria vaccines were discussed by SAGE in April 2017; evidence presented at these meetings can be accessed at: www.who.int/immunization/sage/meetings/2017/april/presentations_background_docs/en/.
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Provision of five or six doses of tetanus or diphtheria vaccine in childhood provides lifelong protection.
“It is known that provision of five or six doses of tetanus45 or diphtheria46 vaccine in childhood provides lifelong protection”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [46]
Cites
Diphtheria vaccine: WHO position paper, August 2017, Weekly epidemiological record, No. 31; 2017. p. 92, 417–36.
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UnresolvedDiphtheria vaccine: WHO position paper, 2006, Weekly epidemiological record, No. 3; 2006. p. 21–32.
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UnresolvedEvidence to recommendation table. Evidence to recommendation table. Available at <http://www.who.int/immunization/policy/position_papers/diphtheria_evidence_recommendation_table.pdf>.
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UnresolvedTetanus vaccines: WHO position paper – February 2017, Weekly epidemiological record, No. 6; 2017. p. 53–76.
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UnresolvedReducing pain at the time of vaccination: WHO position paper – September 2015, Weekly epidemiological record, No. 39; 2015. p. 505–10.
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- Authors
- World Health Organization
- Affiliations
- World Health Organization (CH)
- Corresponding author
- World Health Organization
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 36
- Issue
- 2
- Pages
- 199-201
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W4210337534
- Cited by
- 79
- References
- 5
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 17 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 2
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Diphtheria, Corynebacterium, and Tetanus
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- diphtheria vaccine, diphtheria, vaccination schedule, vaccine dose number, vaccination timing, combined vaccine, childhood immunization, routine immunization, WHO guidelines
- MeSH terms
- Adolescent, Child, Child, Preschool, Diphtheria, Diphtheria Toxoid, Humans, Immunization Schedule, Infant, Global Health, World Health Organization
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