In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum
Abstract
We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).
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Terbinafine acted antagonistically in combination with FLV against P. insidiosum, with reduced antifungal activity compared to when they were applied alone.
“Terbinafine acted antagonistically in combination with FLV against P. insidiosum.Reduced antifungal activity was observed for their combination compared to when they were applied alone [38] .”
From Statins as antifungal agents (2011) · cites this paper as [38]
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- Authors
- Cavalheiro, A. S., Zanette, R. A., Spader, T. B., Lovato, L., Azevedo, M. I., Botton, S., Alves, S. H., & Santurio, J. M.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- Venue
- Veterinary Microbiology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 137
- Issue
- 3-4
- Pages
- 408-411
- ISSN
- 0378-1135 (ISSN-L)
- OpenAlex
- W2067594589
- Cited by
- 42
- References
- 14
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 1 · 2012: 5
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Resistance
- Keywords
- Pythium insidiosum, terbinafine, amphotericin B, fluvastatin, rifampicin, metronidazole, ibuprofen, combination antifungal therapy, drug synergy, drug antagonism, in vitro antifungal activity, clinical isolates
- MeSH terms
- Terbinafine, Fluvastatin, Amphotericin B, Anti-Infective Agents, Anti-Inflammatory Agents, Non-Steroidal, Drug Synergism, Drug Therapy, Combination, Fatty Acids, Monounsaturated, Ibuprofen, Indoles, Metronidazole, Microbial Sensitivity Tests, Naphthalenes, Pythium, Rifampin
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