Cited by 42Infectious Diseases and MycologyAntifungal resistance and susceptibilityPlant Pathogens and Resistance

In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum

Cavalheiro, Ayrton S., Zanette, Régis A., Spader, Tatiana B., Lovato, Luciane, Azevedo, Maria Isabel, Botton, Sonia, Alves, Sydney H., Santurio, Janio M.·2009·Veterinary Microbiology

Abstract

We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).

Integrity signals

Registry

Crossref · 10.1016/j.vetmic.2009.01.036

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15 of 15 references verified0 citation errors · 0 not checkable

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  • Terbinafine acted antagonistically in combination with FLV against P. insidiosum, with reduced antifungal activity compared to when they were applied alone.

    “Terbinafine acted antagonistically in combination with FLV against P. insidiosum.Reduced antifungal activity was observed for their combination compared to when they were applied alone [38] .”

    From Statins as antifungal agents (2011) · cites this paper as [38]

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Authors
Cavalheiro, A. S., Zanette, R. A., Spader, T. B., Lovato, L., Azevedo, M. I., Botton, S., Alves, S. H., & Santurio, J. M.
Affiliations
Universidade Federal de Santa Maria (BR)
Venue
Veterinary Microbiology
Publisher
Elsevier BV
Published
2009-06
Volume
137
Issue
3-4
Pages
408-411
ISSN
0378-1135 (ISSN-L)
OpenAlex
W2067594589
Cited by
42
References
14
Citations by year
2025: 1 · 2023: 3 · 2022: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 1 · 2012: 5
FWCI
7.76
Type
journal article
Language
en
Open access
closed
Locations
  • Veterinary Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Resistance
Keywords
Pythium insidiosum, terbinafine, amphotericin B, fluvastatin, rifampicin, metronidazole, ibuprofen, combination antifungal therapy, drug synergy, drug antagonism, in vitro antifungal activity, clinical isolates
MeSH terms
Terbinafine, Fluvastatin, Amphotericin B, Anti-Infective Agents, Anti-Inflammatory Agents, Non-Steroidal, Drug Synergism, Drug Therapy, Combination, Fatty Acids, Monounsaturated, Ibuprofen, Indoles, Metronidazole, Microbial Sensitivity Tests, Naphthalenes, Pythium, Rifampin

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