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Cited by 10Helminth infection and controlParasitic infections in humans and animalsParasitic Diseases Research and Treatment

Comparative effects of milbemycin oxime-based and febantel–pyrantel embonate-based anthelmintic tablets on Toxocara canis egg shedding in naturally infected pups

Schenker, R., Cody, R., Strehlau, G., Alexander, D., Junquera, P.·2006·Veterinary Parasitology
DOI 10.1016/j.vetpar.2006.01.023
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Abstract

The effect of two treatment programmes on egg shedding in dogs naturally infected with Toxocara canis, one based on a milbemycin oxime-praziquantel-lufenuron combination (SENTINEL) Spectrum; Group 1) and the other based on a febantel-pyrantel embonate-praziquantel combination (DRONTAL) Plus; Group 2), was compared in a study involving 104 suckling pups from three different kennels. The animals in Group 1 were treated at a minimum milbemycin oxime dose of 0.5 mg/kg bw starting at 2 weeks of age and subsequently every 4 weeks until reaching 26 weeks of age. The animals in Group 2 were treated every 2 weeks from week 2 until week 12 of age and then once at week 26 at a minimum febantel and pyrantel embonate dose of 15.0 and 14.4 mg/kg bw, respectively. Toxocara egg counts were determined fortnightly starting at 2 weeks of age and continuing until 26 weeks of age for every pup. Any adverse drug event was recorded during the trial. Both treatment programmes significantly reduced the zoonotic Toxocara egg shedding and were well tolerated by the pups. The pups in Group 1 showed lower average faecal egg counts and were found more frequently shedding no eggs than the pups in Group 2.

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Crossref · 10.1016/j.vetpar.2006.01.023

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  • A recent study has shown the efficacy of two associations, milbemycin oxime-based (99.9%) and febantel/pyrantel-based (98.5%), in reducing shedding of Toxocara eggs.

    “a recent study has shown the efficacy of two associations, i.e. milbemycin oxime-based (99.9%) and febantel/pyrantel -based (98.5%), in reducing shedding of Toxocara eggs [173]”

    From Pet roundworms and hookworms: A continuing need for global worming (2012) · cites this paper as [173]

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Authors
Schenker, R., Cody, R., Strehlau, G., Alexander, D., & Junquera, P.
Affiliations
Novartis (Switzerland) (CH)
Corresponding author
Junquera, P.
ORCID
Junquera, P.
Venue
Veterinary Parasitology
Publisher
Elsevier BV
Published
2006-04
Volume
137
Issue
3-4
Pages
369-373
ISSN
0304-4017 (ISSN-L)
DOI
10.1016/j.vetpar.2006.01.023
OpenAlex
W2057381423
Cited by
10
References
14
Citations by year
2023: 1 · 2021: 2 · 2017: 1 · 2016: 1 · 2012: 1
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Veterinary Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
Toxocara canis, toxocariasis, milbemycin oxime, febantel, pyrantel embonate, praziquantel, anthelmintic combination therapy, zoonotic parasites, drug tolerability, adverse drug reactions
MeSH terms
Animals, Animals, Suckling, Anthelmintics, Dog Diseases, Dogs, Dose-Response Relationship, Drug, Feces, Guanidines, Parasite Egg Count, Pyrantel Pamoate, Toxocariasis, Treatment Outcome, Toxocara canis, Macrolides

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