Susceptibility of helminth species from horses against different chemical compounds in Brazil

Felippelli, Gustavo; Cruz, Breno Cayeiro; Gomes, Lucas Vinicius Costa; Lopes, Welber Daniel Zanetti; Teixeira, Weslen Fabrício Pires; Maciel, Willian Giquelin; Buzzulini, Carolina; Bichuette, Murilo Abud; Campos, Gabriel Pimentel; Soares, Vando Edésio; Bergamasco, Paula Luzia Formigoni; Oliveira, Gilson Pereira de; Costa, Alvimar José da

doi:10.1016/j.vetpar.2015.07.041

Cited by 34Helminth infection and controlVeterinary Equine Medical ResearchVeterinary Pharmacology and Anesthesia

Susceptibility of helminth species from horses against different chemical compounds in Brazil

Felippelli, Gustavo, Cruz, Breno Cayeiro, Gomes, Lucas Vinicius Costa, Lopes, Welber Daniel Zanetti, Teixeira, Weslen Fabrício Pires, Maciel, Willian Giquelin, Buzzulini, Carolina, Bichuette, Murilo Abud +5 more·2015·Veterinary Parasitology

DOI 10.1016/j.vetpar.2015.07.041

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Abstract

By means of parasitological necropsies, the present study aimed to evaluate, in six experiments, the degree of susceptibility or resistance of different helminth species which naturally infect horses to ivermectin 0.2 mg/kg, abamectin 0.2 mg/kg, moxidectin 0.4 mg/kg, trichlorfon 35 mg/kg, ivermectin 0.2 mg/kg+praziquantel 2.5 mg/kg, abamectin 0.2 mg/kg+praziquantel 2.5 mg/kg and ivermectin 0.2 mg/kg+6.6 mg/kg pyrantel. At experimental day zero, the horses were allocated to treatment groups based on average counts of strongylid eggs per gram of feces (EPG) obtained on days -3, -2 and -1. Oxyuris sp. infections were confirmed as positive or negative. All the animals in the six experiments were naturally infected by this helminth species. Each group (control or treated) consisted of six animals. All the assessed Habronema muscae populations analyzed were susceptible to ivermectin, abamectin and moxidectin. Of the six Trichostrongylus axei populations, four were susceptible to ivermectin, abamectin, moxidectin, trichlorfon and ivermectin+praziquantel, and two were resistant to abamectin+praziquantel and ivermectin+pyrantel. Both Strongyloides westeri populations analyzed were susceptible to ivermectin, abamectin, moxidectin and abamectin+praziquantel. For O. equi, resistance was found in four different populations treated with ivermectin, abamectin, moxidectin, trichlorfon and ivermectin+praziquantel. Only combinations of abamectin+praziquantel and ivermectin+pyrantel were effective against this parasite species. All the large strongyles diagnosed in the present study (Strongyus edentatus, Strongyus vulgaris and Triodontophorus serratus) were susceptible to all the chemicals tested, with the exception of trichlorfon. Of the Cyathostominae populations, one was diagnosed as resistant to ivermectin and another to trichlorfon. The remaining populations from this nematode group were considered to be sensitive to ivermectin, abamectin, moxidectin, ivermectin+praziquantel, abamectin+praziquantel and ivermectin+pyrantel. New studies should be performed in different regions to evaluate the efficacy of trichlorfon in others field populations of helminthes.

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A more recent study from Brazil demonstrated an efficacy of 92-95%, 98-100%, and 100% of ivermectin, abamectin, and moxidectin, respectively, against H. muscae.
“A more recent study from Brazil demonstrated an efficacy of 92–95%, 98–100%, and 100% of ivermectin, abamectin, and moxidectin, respectively, against H. muscae (76).”
From Habronematidosis in Equids: Current Status, Advances, Future Challenges (2020) · cites this paper as [76]

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Authors: Felippelli, G., Cruz, B. C., Gomes, L. V. C., Lopes, W. D. Z., Teixeira, W. F. P., Maciel, W. G., Buzzulini, C., Bichuette, M. A., Campos, G. P., Soares, V. E., Bergamasco, P. L. F., Oliveira, G. P. D., & Costa, A. J. D.
Affiliations: Universidade Estadual Paulista (Unesp) (BR)
Universidade Federal de Goiás (BR)
Corresponding author: Lopes, Welber Daniel Zanetti
ORCID: Felippelli, Gustavo
Cruz, Breno Cayeiro
Lopes, Welber Daniel Zanetti
Teixeira, Weslen Fabrício Pires
Maciel, Willian Giquelin
Soares, Vando Edésio
Costa, Alvimar José da
Venue: Veterinary Parasitology
Publisher: Elsevier BV
Published: 2015-09
Volume: 212
Issue: 3-4
Pages: 232-238
ISSN: 0304-4017 (ISSN-L)
DOI: 10.1016/j.vetpar.2015.07.041
OpenAlex: W1052914617
Cited by: 34
References: 36
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2
FWCI: 3.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Veterinary Parasitology (publishedVersion)
PubMed (publishedVersion)
Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Topics: Health Sciences › Veterinary › Small Animals › Helminth infection and control
Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
Keywords: anthelmintic resistance, horses, ivermectin, abamectin, moxidectin, trichlorfon, praziquantel, pyrantel, Strongyloides westeri, Oxyuris equi, Strongylus edentatus, Strongylus vulgaris, Cyathostominae, Trichostrongylus axei, Habronema muscae, anthelmintic combination
MeSH terms: Animals, Anthelmintics, Brazil, Drug Resistance, Helminthiasis, Animal, Helminths, Horse Diseases, Horses

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Susceptibility of helminth species from horses against different chemical compounds in Brazil

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