Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes
Open accessAbstract
Cytotoxic T lymphocyte (CTL) senescence may be an important mechanism of immune failure in HIV-1 infection. We find that senescence of HIV-1-specific CTL clones causes loss of killing activity, preventable by transduction with telomerase. Furthermore, senescence is associated with reduced expression of the effector molecules granzyme and perforin, suggesting CTL "exhaustion" can result in hypofunction. These results agree with other studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest the possibility that chronic turnover is an important mechanism of antiviral failure in HIV-1 infection.
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From p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes (2013) · cites this paper as [42]
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- Authors
- Yang, O. O., Lin, H., Dagarag, M., Ng, H. L., Effros, R. B., & Uittenbogaart, C. H.
- Affiliations
- University of California, Los Angeles (US)
- Ronald Reagan UCLA Medical Center (US)
- Corresponding author
- Yang, Otto O.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 332
- Issue
- 1
- Pages
- 16-19
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2010574039
- Cited by
- 79
- References
- 14
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Virology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI054286, AI043203, AI054286, R01AI043203)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- perforin, granzyme B, telomerase
- MeSH terms
- Aging, Chronic Disease, Humans, Membrane Glycoproteins, Serine Endopeptidases, T-Lymphocytes, Cytotoxic, HIV-1, T-Lymphocyte Subsets, Cellular Senescence, Pore Forming Cytotoxic Proteins, Granzymes, Perforin
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