Age-Dependent Association between Low Frequency of CD27/CD28 Expression on pp65 CD8+T Cells and Cytomegalovirus Replication after Transplantation
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In this cross-sectional study of 42 solid organ transplant recipients, the association of human cytomegalovirus (HCMV) replication and age with the phenotype of the HCMV-specific CD8+T cells was analyzed by using the CMV pp65 HLA-A*0201 pentamer. A correlation between the proportion of CD28−HCMV-specific CD8+T cells and age was observed in patients without HCMV replication (r= 0.50;P= 0.02) but not in patients with HCMV replication (r= −0.05;P= 0.83), a finding which differs from that observed for total CD8+T cells. Within the group of patients younger than 50 years of age, patients with HCVM replication after transplantation had higher percentages of CD28−HCMV-specific CD8+T cells (85.6 compared with 58.7% for patients without HCMV replication;P= 0.004) and CD27−HCMV-specific CD8+T cells (90.7 compared with 68.8% for patients without HCMV replication;P= 0.03). However, in patients older than age 50 years, a high frequency of these two subpopulations was observed in patients both with and without previous HCMV replication (for CD28−HCMV-specific CD8+T cells, 84.4 and 80.9%, respectively [P= 0.39]; for CD27−HCMV-specific CD8+T cells 86.6 and 81.5%, respectively [P= 0.16]). In conclusion, the present study shows that in the group of recipients younger than age 50 years, HCMV replication after transplantation is associated with a high percentage of CD27−and CD28−HCMV-specific CD8+T cells. These results suggest that the increased percentage of CD27−or CD28−HCMV-specific subsets can be considered a biomarker of HCMV replication in solid organ transplant recipients younger than age 50 years but not in older patients. Further studies are necessary to define the significance of these changes in HCMV-associated clinical complications posttransplantation.
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CMV reactivation causes an expansion of TEMRA cells, compared to other persistent infections that periodically reactivate (e.g., EBV).
“compared to other persistent infections that periodically reactivate (e.g., EBV) it is CMV reactivation that causes an expansion of these cells (Cantisan et al. 2009; Fulop et al. 2013; Gamadia et al. 2004).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Cantisan et al. 2009
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Is immunosenescence influenced by our lifetime “dose” of exercise?
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- Authors
- Cantisán, S., Torre-Cisneros, J., Lara, R., Rodríguez-Benot, A., Santos, F., Gutiérrez-Aroca, J., Gayoso, I., González-Padilla, M., Casal, M., Rivero, A., & Solana, R.
- Affiliations
- Instituto Maimónides para la Investigación Biomédica de Córdoba, Spanish Network for Research in Infectious Diseases, Avda. Menéndez Pidal, s/n, Córdoba 14004, Spain
- Infectious Diseases Unit
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Nephrology Department, Renal Transplant Unit
- Pneumology Department, Lung Transplant Unit
- Microbiology Department
- Hospital Universitario Reina Sofía (ES)
- Venue
- Clinical and Vaccine Immunology
- Publisher
- American Society for Microbiology
- Published
- 2009-10
- Volume
- 16
- Issue
- 10
- Pages
- 1429-1438
- ISSN
- 1556-679X (ISSN-L)
- 1556-6811
- PMC
- PMC2756845
- OpenAlex
- W2150301103
- Cited by
- 27
- References
- 57
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Clinical and Vaccine Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- human cytomegalovirus, HCMV reactivation, solid organ transplant recipients, CD8+ T cells, CD27, CD28, age, HLA-A*0201, biomarkers, cytomegalovirus infection, T cell subsets, immunosenescence, post-transplant complications, CMV serostatus
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Cross-Sectional Studies, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Male, Middle Aged, Phosphoproteins, Transplantation Immunology, Viral Matrix Proteins, Virus Replication, Kidney Transplantation, Lung Transplantation, T-Lymphocyte Subsets, CD28 Antigens, Tumor Necrosis Factor Receptor Superfamily, Member 7, CD8-Positive T-Lymphocytes, Transplants, Granzymes, Perforin, Young Adult
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