The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
Open accessAbstract
Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Base-Calling of Automated Sequencer Traces Using Phred. II. Error Probabilities
Ewing, B., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.186 · Cited by 5,439
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Brudno, M., Do, C. B., Cooper, G. M., Kim, M. F., Davydov, E., Program, N. C. S., Green, E. D., Sidow, A., & Batzoglou, S. (2003) · Genome Research · doi:10.1101/gr.926603 · Cited by 1,115
Cited by
Gessain, A., Nakoune, E., & Yazdanpanah, Y. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2208860 · Cited by 409
Monkeypox virus and insights into its immunomodulatory proteins
Weaver, J. R., & Isaacs, S. N. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00691.x · Cited by 295
Smallpox vaccines: targets of protective immunity
Moss, B. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00975.x · Cited by 259
Genomic and transcriptomic analysis of the recent Mpox outbreak
Giorgi, F. M., Pozzobon, D., Di Meglio, A., & Mercatelli, D. (2024) · Vaccine · doi:10.1016/j.vaccine.2023.12.086 · Cited by 64
Metadata
- Authors
- Chen, N., Li, G., Liszewski, M. K., Atkinson, J. P., Jahrling, P. B., Feng, Z., Schriewer, J., Buck, C., Wang, C., Lefkowitz, E. J., Esposito, J. J., Harms, T., Damon, I. K., Roper, R. L., Upton, C., & Buller, R. M. L.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 340
- Issue
- 1
- Pages
- 46-63
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2079003813
- Cited by
- 533
- References
- 3
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, N., Li, G., Liszewski, M. K., Atkinson, J. P., Jahrling, P. B., Feng, Z., Schriewer, J., Buck, C., Wang, C., Lefkowitz, E. J., Esposito, J. J., Harms, T., Damon, I. K., Roper, R. L., Upton, C., & Buller, R. M. L. (2005). Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology. https://doi.org/10.1016/j.virol.2005.05.030
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