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E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway
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“E6 has been shown to inactivate PTEN, leading to increased pAKT and increased cell proliferation [229]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [229]
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PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
Sun, S., & Steinberg, B. M. (2002) · Journal of General Virology · doi:10.1099/0022-1317-83-7-1651 · Cited by 101 · cited 1×
“The answer to this query may be found in that the proportion of pPKB may be a result not only of activating kinases (PDK1, PDK2), but also of inactivating phosphatases (PP2A, STAT3) (Pim et al., 2005; Sun and Steinberg, 2002) that may be modulating the final proportion of activated pPKB.”
Background
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Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Contreras-Paredes, A., De la Cruz-Hernández, E., Martínez-Ramírez, I., Dueñas-González, A., & Lizano, M.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 383
- Issue
- 1
- Pages
- 78-85
- ISSN
- 0042-6822
- Cited by
- 82
- References
- 1
- Language
- en
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- Contreras-Paredes, A., De la Cruz-Hernández, E., Martínez-Ramírez, I., Dueñas-González, A., & Lizano, M. (2009). E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. Virology. https://doi.org/10.1016/j.virol.2008.09.040