The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Papillomavirus E6 proteins
Open accessAbstract
The papillomaviruses are small DNA viruses that encode approximately eight genes, and require the host cell DNA replication machinery for their viral DNA replication. Thus papillomaviruses have evolved strategies to induce host cell DNA synthesis balanced with strategies to protect the cell from unscheduled replication. While the papillomavirus E1 and E2 genes are directly involved in viral replication by binding to and unwinding the origin of replication, the E6 and E7 proteins have auxillary functions that promote proliferation. As a consequence of disrupting the normal checkpoints that regulate cell cycle entry and progression, the E6 and E7 proteins play a key role in the oncogenic properties of human papillomaviruses with a high risk of causing anogenital cancers (HR HPVs). As a consequence, E6 and E7 of HR HPVs are invariably expressed in cervical cancers. This article will focus on the E6 protein and its numerous activities including inactivating p53, blocking apoptosis, activating telomerase, disrupting cell adhesion, polarity and epithelial differentiation, altering transcription and reducing immune recognition.
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1 retracted
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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
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Cited by
Human papillomavirus oncoproteins: pathways to transformation
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The human papillomavirus family and its role in carcinogenesis
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Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology
Gheit, T. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00355 · Cited by 325
den Boon, J. A., Pyeon, D., Wang, S. S., Horswill, M., Schiffman, M., Sherman, M., Zuna, R. E., Wang, Z., Hewitt, S. M., Pearson, R., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509322112 · Cited by 291
Spangle, J. M., & Münger, K. (2010) · Journal of Virology · doi:10.1128/jvi.00974-10 · Cited by 189
Metadata
- Authors
- Howie, H. L., Katzenellenbogen, R. A., & Galloway, D. A.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 384
- Issue
- 2
- Pages
- 324-334
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2093710784
- Cited by
- 332
- References
- 153
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Howie, H. L., Katzenellenbogen, R. A., & Galloway, D. A. (2009). Papillomavirus E6 proteins. Virology. https://doi.org/10.1016/j.virol.2008.11.017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
