Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Open accessAbstract
Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus-cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection. In vivo experiments revealed that IFN-α2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses.
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Genomic studies of SARS-CoV infection in ferrets showed enhanced expression of chemokine ligands, in particular CCL2, CCL4, CCL14, CCL19, and CCL25.
“Genomic studies of SARS-CoV infection in ferrets showed enhanced expression of chemokine ligands, in particular, CCL2, CCL4, CCL14, CCL19, and CCL25 (37).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [37]
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- Authors
- Danesh, A., Cameron, C. M., León, A. J., Ran, L., Xu, L., Fang, Y., Kelvin, A. A., Rowe, T., Chen, H., Guan, Y., Jonsson, C. B., Cameron, M. J., & Kelvin, D. J.
- Affiliations
- University Health Network (CA)
- Shantou University (CN)
- University of Louisville (US)
- Corresponding author
- Kelvin, David J.
- ORCID
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 409
- Issue
- 1
- Pages
- 102-112
- ISSN
- 0042-6822 (ISSN-L)
- PMC
- PMC7111932
- OpenAlex
- W1978317159
- Cited by
- 51
- References
- 32
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 8 · 2020: 21 · 2019: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 6
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Li Ka Shing Foundation
- NIH/NIAID (NOI-AI-30063C11)
- Southern Research Institute (NOI-AI-30067)
- Canadian Institute of Health Research (CIHR-200904PAP-203553-PAM-ADHD-48072)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- SARS-CoV, ferrets, type I interferon, interferon alfa-2b, STAT1 phosphorylation, interferon response genes, chemokine receptors, phagocytosis, leukocyte transendothelial migration, cell migration, inflammation, antiviral response, gene expression profiling
- MeSH terms
- Interferon alpha-2, Animals, Disease Models, Animal, Ferrets, Gene Expression Regulation, Humans, Male, Molecular Sequence Data, Proteins, Recombinant Proteins, Up-Regulation, Interferon-alpha, Sequence Analysis, DNA, Gene Expression Profiling, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, STAT1 Transcription Factor
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