WNT signalling in the immune system: WNT is spreading its wings
Abstract
WNT proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. In blood and immune cells, WNT signalling controls the proliferation of progenitor cells and might also affect the cell-fate decisions of stem cells. Recent studies indicate that WNT proteins also regulate effector T-cell development, regulatory T-cell activation and dendritic-cell maturation. WNT signalling seems to function as a universal mechanism in leukocytes to establish a pool of undifferentiated cells for further selection, effector-cell maturation and terminal differentiation. WNT signalling is therefore subject to strict molecular control, and dysregulated WNT signalling is implicated in the development of haematological malignancies.
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Most studies investigating immune and blood cells have found canonical Wnt signalling to be integral, affecting haematopoietic stem cell self-renewal, B-cell development in the bone marrow, dendritic cell maturation, and T-cell activation and migration.
“Most of the studies investigating immune and blood cells have found canonical Wnt signalling to be integral, since it has been shown to affect parts of haematopoietic stem cell self-renewal, B-cell development in the bone marrow, dendritic cell maturation and T-cell activation and migration [40,41].”
From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [40]
Cites
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“Most of the studies investigating immune and blood cells have found canonical Wnt signalling to be integral, since it has been shown to affect parts of haematopoietic stem cell self-renewal, B-cell development in the bone marrow, dendritic cell maturation and T-cell activation and migration [40,41].”
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- Authors
- Staal, F. J. T., Luis, T. C., & Tiemessen, M. M.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Staal, Frank J. T.
- Venue
- Nature Reviews Immunology
- Published
- 2008-08
- Volume
- 8
- Issue
- 8
- Pages
- 581-593
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1974595623
- Cited by
- 582
- References
- 4
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 20 · 2023: 28 · 2022: 28 · 2021: 40 · 2020: 43 · 2019: 37 · 2018: 38 · 2017: 36 · 2016: 45 · 2015: 40 · 2014: 29 · 2013: 27 · 2012: 36
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-04-07)
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, immune system, hematopoietic stem cells, T cell development, B cell development, dendritic cell maturation, regulatory T cells, hematologic malignancies, progenitor cell proliferation, cell fate specification, asymmetric cell division, morphogens
- MeSH terms
- Animals, Hematopoietic Stem Cells, Humans, Signal Transduction, Wnt Proteins
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