Cited by 239Virus-based gene therapy researchImmunotherapy and Immune Responsesinterferon and immune responses

The DOI matches its Crossref record; 101 of the 109 references it cites were found in a registry or an index, and 8 are not checked yet.

Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.

Open access

Hartman, Zachary C., Appledorn, Daniel M., Amalfitano, Andrea·2008·Virus Research

DOI 10.1016/j.virusres.2007.10.005PMC PMC4039020

Open this paper in CoChat — free account

Abstract

Extensively characterized, modified, and employed for a variety of purposes, adenovirus (Ad) vectors are generally regarded as having great potential by many applied virologists who wish to manipulate and use viral biology to achieve beneficial clinical outcomes. Despite widespread functional prominence and utility (i.e., Ad-based clinical trials have begun to progress to critical Phase III levels, it has recently become apparent that investigations regarding the innate immune response to Ads may reveal not only reasons behind previous failures, but also reveal novel insights that will allow for safer, more efficacious uses of this important gene transfer platform. Insights gained by the exploration of Ad induced innate immune responses will likely be most important to the fields of vaccine development, since Ad-based vaccines are regarded as one of the more promising vaccine platforms in development today. Adenovirus is currently known to interact with several different extracellular, intracellular, and membrane-bound innate immune sensing systems. Past and recent studies involving manipulation of the Ad infectious cycle as well as use of different mutants have shed light on some of the initiation mechanisms underlying Ad induced immune responses. More recent studies using microarray-based analyses, genetically modified cell lines and/or mouse mutants, and advanced generation Ad vectors have revealed important new insights into the scope and mechanism of this cellular defensive response. This review is an attempt to synthesize these studies, update Ad biologists to the current knowledge surrounding these increasingly important issues, as well as highlight areas where future research should be directed. It should also serve as a sobering reality to researchers exploring the use of any gene transfer vector, as to the complexities potentially involved when contemplating use of such vectors for human applications.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.virusres.2007.10.005

Cites

101 of 109 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
Phylogenetic Perspectives in Innate Immunity
Hoffmann, J. A., Kafatos, F. C., Janeway, C. A., & Ezekowitz, R. A. B. (1999) · Science · doi:10.1126/science.284.5418.1313 · Cited by 2,524
Decoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849
Innate immune sensing and its roots: the story of endotoxin
Beutler, B., & Rietschel, E. (2003) · Nature reviews. Immunology · doi:10.1038/nri1004 · Cited by 1,392
Cell Type-Specific Involvement of RIG-I in Antiviral Response
Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.010 · Cited by 1,368
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
Lund, J. M., Sato, A., Akira, S., Medzhitov, R. M., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,197
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M., & Colonna, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603082103 · Cited by 1,177
Multiple-laboratory comparison of microarray platforms
Irizarry, R. A., Warren, D., Spencer, F., Kim, I. F., Biswal, S., Frank, B. C., Gabrielson, E., Garcia, J. G. N., Geoghegan, J., Germino, G., et al. (2005) · Nature Methods · doi:10.1038/nmeth756 · Cited by 862
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
Lee, M. S., & Kim, Y. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060605.122847 · Cited by 781
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
Ishii, K. J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., et al. (2005) · Nature Immunology · doi:10.1038/ni1282 · Cited by 771
A Helper-Dependent Adenovirus Vector System: Removal of Helper Virus by Cre-Mediated Excision of the Viral Packaging Signal
Parks, R. J., Chen, L., Anton, M., Sankar, U., Rudnicki, M. A., & Graham, F. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13565 · Cited by 725
Evaluation of gene expression measurements from commercial microarray platforms
Tan, P. K. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg763 · Cited by 705
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2
Compton, T., Kurt‐Jones, E. A., Boehme, K. W., Belko, J., Latz, E., Golenbock, D. T., & Finberg, R. W. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4588-4596.2003 · Cited by 676
The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses
Sun, Q., Sun, L., Liu, H.-H., Chen, X., Seth, R. B., Forman, J., & Chen, Z. J. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.004 · Cited by 604
Type I interferons produced by dendritic cells promote their phenotypic and functional activation
Montoya, M., Schiavoni, G., Mattei, F., Gresser, I., Belardelli, F., Borrow, P., & Tough, D. F. (2002) · Blood · doi:10.1182/blood.v99.9.3263 · Cited by 534
Hemagglutinin Protein of Wild-Type Measles Virus Activates Toll-Like Receptor 2 Signaling
Bieback, K., Lien, E., Klagge, I. M., Avota, E., Schneider‐Schaulies, J., Duprex, W. P., Wagner, H., Kirschning, C. J., ter Meulen, V., & Schneider‐Schaulies, S. (2002) · Journal of Virology · doi:10.1128/jvi.76.17.8729-8736.2002 · Cited by 516
Essential role of IPS-1 in innate immune responses against RNA viruses
Kumar, H., Kawai, T., Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K. J., Takeuchi, O., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060792 · Cited by 503
Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus
Haynes, L. M., Moore, D. D., Kurt‐Jones, E. A., Finberg, R. W., Anderson, L. J., & Tripp, R. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.10730-10737.2001 · Cited by 496
Murine retroviruses activate B cells via interaction with toll-like receptor 4
Rassa, J., Meyers, J., Zhang, Y., Kudaravalli, R., & Ross, S. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.042355399 · Cited by 493
Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors Following In Vivo Administration
Worgall, S., Wolff, G., Falck-Pedersen, E., & Crystal, R. G. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.1-37 · Cited by 487
Adenoviral Gene Therapy Leads to Rapid Induction of Multiple Chemokines and Acute Neutrophil-Dependent Hepatic Injury in Vivo
Muruve, D. A., Barnes, M. J., Stillman, I. E., & Libermann, T. A. (1999) · Human Gene Therapy · doi:10.1089/10430349950018364 · Cited by 447
Molecular basis of the inflammatory response to adenovirus vectors
Liu, Q., & Muruve, D. A. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302036 · Cited by 430
Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity
Shayakhmetov, D. M., Gaggar, A., Ni, S., Li, Z.-Y., & Lieber, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7478-7491.2005 · Cited by 429
The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells
Means, T. K., Hayashi, F., Smith, K. D., Aderem, A. A., & Luster, A. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5165 · Cited by 416
The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors
Lieber, A., He, C. Y., Meuse, L., Schowalter, D., Kirillova, I., Winther, B., & Kay, M. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8798-8807.1997 · Cited by 411
PEGylation of Adenovirus with Retention of Infectivity and Protection from Neutralizing Antibody in Vitro and in Vivo
O’Riordan, C. R., Lachapelle, A., Delgado, C., Parkes, V., Wadsworth, S. C., Smith, A. E., & Francis, G. E. (1999) · Human Gene Therapy · doi:10.1089/10430349950018021 · Cited by 409
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
Krieg, A. Μ., Wu, T., Weeratna, R. D., Efler, S. M., Love-Homan, L., Yang, L., Yi, A., Short, D., & Davis, H. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12631 · Cited by 396
Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors
Zaiss, A.-K., Liu, Q., Bowen, G. P., Wong, N. C. W., Bartlett, J. S., & Muruve, D. A. (2002) · Journal of Virology · doi:10.1128/jvi.76.9.4580-4590.2002 · Cited by 394
Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways
Zhu, J., Huang, X., & Yang, Y. (2007) · Journal of Virology · doi:10.1128/jvi.02192-06 · Cited by 370
A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.
Ginsberg, H. S., Moldawer, L. L., Sehgal, P. B., Redington, M., Kilian, P. L., Chanock, R. M., & Prince, G. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1651 · Cited by 353
Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver
Tao, N., Gao, G., Parr, M. J., Johnston, J., Baradet, T. C., Wilson, J. M., Barsoum, J., & Fawell, S. E. (2001) · Molecular Therapy · doi:10.1006/mthe.2000.0227 · Cited by 321
Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy
Jooss, K. U., & Chirmule, N. B. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302037 · Cited by 278
Reactivation of the Previously Silenced Cytomegalovirus Major Immediate-Early Promoter in the Mouse Liver: Involvement of NFκB
Löser, P., Jennings, G. S., Strauss, M., & Sandig, V. (1998) · Journal of Virology · doi:10.1128/jvi.72.1.180-190.1998 · Cited by 277
Comprehensive comparison of six microarray technologies
Yauk, C. L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh123 · Cited by 244
Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
Applequist, S. E. (2002) · International Immunology · doi:10.1093/intimm/dxf069 · Cited by 238
Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
Bruder, J. T., & Kovesdi, I. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.398-404.1997 · Cited by 230
Adenovirus Serotype 5 Fiber Shaft Influences In Vivo Gene Transfer in Mice
Smith, T. A., Idamakanti, N., Rollence, M. L., Marshall-Neff, J., Kim, J., Mulgrew, K. A., Nemerow, G. R., Kaleko, M., & Stevenson, S. C. (2003) · Human Gene Therapy · doi:10.1089/104303403765255165 · Cited by 215
Reducing the Native Tropism of Adenovirus Vectors Requires Removal of both CAR and Integrin Interactions
Einfeld, D. A., Schroeder, R., Roelvink, P. W., Lizonová, A., King, C. R., Kovesdi, I., & Wickham, T. J. (2001) · Journal of Virology · doi:10.1128/jvi.75.23.11284-11291.2001 · Cited by 213
Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors
Shayakhmetov, D. M., Li, Z.-Y., Ni, S., & Lieber, A. (2004) · Journal of Virology · doi:10.1128/jvi.78.10.5368-5381.2004 · Cited by 210
Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
Shi, L. M., Tong, W., Fang, H., Scherf, U., Han, J., Puri, R. K., Frueh, F. W., Goodsaid, F. M., Guo, L., Su, Z., et al. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-s2-s12 · Cited by 201
TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection
Trevejo, J., Marino, M. W., Philpott, N. J., Josien, R., Richards, E. C., Elkon, K. B., & Falck-Pedersen, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211423598 · Cited by 198
High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells
Dietz, A. B., & Vuk‐Pavlović, S. (1998) · Blood · doi:10.1182/blood.v91.2.392.392_392_398 · Cited by 193
The influence of adenovirus fiber structure and function on vector development for gene therapy
Nicklin, S. A., Wu, E. Y., Nemerow, G. R., & Baker, A. H. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.05.008 · Cited by 185
Temperature-sensitive Mutants of Adenovirus defective in Interferon Induction at Non-permissive Temperature
Ustaçelebi, S., & Williams, J. (1972) · Nature · doi:10.1038/235052a0 · Cited by 181
Adenovirus-Platelet Interaction in Blood Causes Virus Sequestration to the Reticuloendothelial System of the Liver
Stone, D., Liu, Y., Shayakhmetov, D. M., Li, Z.-Y., Ni, S., & Lieber, A. (2007) · Journal of Virology · doi:10.1128/jvi.02819-06 · Cited by 169
PEGylation of E1-Deleted Adenovirus Vectors Allows Significant Gene Expression on Readministration to Liver
Croyle, M. A., Chirmule, N. B., Zhang, Y., & Wilson, J. M. (2002) · Human Gene Therapy · doi:10.1089/104303402760372972 · Cited by 165
Lethal Toxicity, Severe Endothelial Injury, and a Threshold Effect with High Doses of an Adenoviral Vector in Baboons
Morral, N., O’Neal, W. K., Rice, K., Leland, M. M., Piedra, P. A., Aguilar-Córdova, E., Carey, K. D., Beaudet, A. L., & Langston, C. (2002) · Human Gene Therapy · doi:10.1089/10430340152712692 · Cited by 163
Sensing Infection by Adenovirus: Toll-Like Receptor-Independent Viral DNA Recognition Signals Activation of the Interferon Regulatory Factor 3 Master Regulator
Nociari, M., Ocheretina, O., Schoggins, J. W., & Falck-Pedersen, E. (2007) · Journal of Virology · doi:10.1128/jvi.02685-06 · Cited by 159
Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells
Cheng, G., Zhong, J., Chung, J., & Chisari, F. V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703285104 · Cited by 158
Internalization of Adenovirus by Alveolar Macrophages Initiates Early Proinflammatory Signaling during Acute Respiratory Tract Infection
Zsengellér, Z. K., Otake, K., Hossain, S.-A., Berclaz, P., & Trapnell, B. C. (2000) · Journal of Virology · doi:10.1128/jvi.74.20.9655-9667.2000 · Cited by 156
Replication-Defective Adenovirus Serotype 5 Vectors Elicit Durable Cellular and Humoral Immune Responses in Nonhuman Primates
Santra, S., Seaman, M. S., Xu, L., Barouch, D. H., Lord, C. I., Lifton, M. A., Gorgone, D. A., Beaudry, K. R., Svehla, K., Welcher, B. C., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6516-6522.2005 · Cited by 149
Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors
Schiedner, G., Hertel, S., Johnston, M., Dries, V., van Rooijen, N., & Kochanek, S. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(02)00017-5 · Cited by 148
The Role of Capsid–Endothelial Interactions in the Innate Immune Response to Adenovirus Vectors
Liu, Q., Zaiss, A. K., Colarusso, P., Patel, K. D., Haljan, G. J., Wickham, T. J., & Muruve, D. A. (2003) · Human Gene Therapy · doi:10.1089/104303403321618146 · Cited by 146
Toll-like Receptor 9 Triggers an Innate Immune Response to Helper-dependent Adenoviral Vectors
Cerullo, V., Seiler, M. P., Mane, V. P., Brunetti‐Pierri, N., Clarke, C., Bertin, T., Rodgers, J. R., & Lee, B. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300031 · Cited by 143
TLR-Independent Induction of Dendritic Cell Maturation and Adaptive Immunity by Negative-Strand RNA Viruses
López, C. B., Moltedo, B., Alexopoulou, L., Bonifaz, L. C., Flavell, R. A., & Moran, T. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.6882 · Cited by 143
Receptor Interactions Involved in Adenoviral-Mediated Gene Delivery After Systemic Administration in Non-Human Primates
Smith, T. A., Idamakanti, N., Marshall-Neff, J., Rollence, M. L., Wright, P., Kaloss, M., King, L., Mech, C. A., Dinges, L., Iverson, W. O., et al. (2003) · Human Gene Therapy · doi:10.1089/104303403322542248 · Cited by 138
Adenovirus Infection Triggers a Rapid, MyD88-Regulated Transcriptome Response Critical to Acute-Phase and Adaptive Immune Responses In Vivo
Hartman, Z. C., Kiang, A., Everett, R., Serra, D. M., Yang, X. Y., Clay, T. M., & Amalfitano, A. (2006) · Journal of Virology · doi:10.1128/jvi.01936-06 · Cited by 136
Self-citation
Adenovirus Vector-Induced Expression of the C-X-C Chemokine IP-10 Is Mediated through Capsid-Dependent Activation of NF-κB
Borgland, S. L., Bowen, G. P., Wong, N. C. W., Libermann, T. A., & Muruve, D. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.9.3941-3947.2000 · Cited by 135
Complement activation by recombinant adenoviruses
Cichon, G., Boeckh-Herwig, S., Schmidt, H., Wehnes, E., Müller, T. H., Pring‐Åkerblom, P., & Burger, R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301611 · Cited by 128
Papillomavirus-Like Particles Stimulate Murine Bone Marrow-Derived Dendritic Cells To Produce Alpha Interferon and Th1 Immune Responses via MyD88
Yang, R., Murillo, F., Cui, H., Blosser, R. L., Uematsu, S., Takeda, K., Akira, S., Viscidi, R. P., & Roden, R. B. S. (2004) · Journal of Virology · doi:10.1128/jvi.78.20.11152-11160.2004 · Cited by 123
Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-α induction pathway
Philpott, N. J., Nociari, M., Elkon, K. B., & Falck-Pedersen, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308368101 · Cited by 122
A comparison of cDNA, oligonucleotide, and Affymetrix GeneChip gene expression microarray platforms.
Woo, Y., Affourtit, J. P., Daigle, S. L., Viale, A. J., Johnson, K., Naggert, J. Κ., & Churchill, G. A. (2004) · PubMed Central · Cited by 121
Activation of p38 and ERK Signaling during Adenovirus Vector Cell Entry Lead to Expression of the C-X-C Chemokine IP-10
Tibbles, L. A., Spurrell, J. C. L., Bowen, G. P., Liu, Q., Lam, M., Zaiss, A. K., Robbins, S. M., Hollenberg, M. D., Wickham, T. J., & Muruve, D. A. (2002) · Journal of Virology · doi:10.1128/jvi.76.4.1559-1568.2002 · Cited by 120
Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naïve and pre-immunized mice
Varnavski, A. N., Calcedo, R., Bove, M. S., Gao, G., & Wilson, J. M. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302347 · Cited by 115
Preferential Activation of Toll-Like Receptor Nine by CD46-Utilizing Adenoviruses
Iacobelli-Martinez, M., & Nemerow, G. R. (2006) · Journal of Virology · doi:10.1128/jvi.01926-06 · Cited by 113
Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats
Nicol, C. G., Graham, D., Miller, W. H., White, S. J., Smith, T. A., Nicklin, S. A., Stevenson, S. C., & Baker, A. H. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.05.020 · Cited by 113
The Release of Inflammatory Cytokines from Human Peripheral Blood Mononuclear Cells In Vitro Following Exposure to Adenovirus Variants and Capsid
Higginbotham, J. N., Seth, P. K., Blaese, R. M., & Ramsey, W. J. (2002) · Human Gene Therapy · doi:10.1089/10430340152712683 · Cited by 113
PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile
Croyle, M. A., Le, H. T., Linse, K. D., Cerullo, V., Toietta, G., Beaudet, A. L., & Pastore, L. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302441 · Cited by 113
Evaluation of Biodistribution and Safety of Adenovirus Vectors Containing Group B Fibers After Intravenous Injection into Baboons
Ni, S., Bernt, K. M., Gaggar, A., Li, Z.-Y., Kiem, H., & Lieber, A. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.664 · Cited by 104
Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9‐dependent maturation and IFN‐α production
Basner‐Tschakarjan, E., Gaffal, E., O’Keeffe, M. A., Tormo, D., Limmer, A., Wagner, H., Hochrein, H., & Tüting, T. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.964 · Cited by 102
Simultaneous CAR- and αV integrin-binding ablation fails to reduce Ad5 liver tropism
Martin, K., Brie, A., Saulnier, P., Perricaudet, M., Yeh, P., & Vigne, E. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00182-5 · Cited by 100
SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection
Harrod, K. S., Trapnell, B. C., Otake, K., Korfhagen, T. R., & Whitsett, J. A. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.3.l580 · Cited by 97
Multiple Innate Inflammatory Responses Induced after Systemic Adenovirus Vector Delivery Depend on a Functional Complement System
Kiang, A., Hartman, Z. C., Everett, R., Serra, D. M., Jiang, H., Frank, M. M., & Amalfitano, A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.024 · Cited by 93
Self-citation
Interaction of Adenovirus Type 5 Fiber with the Coxsackievirus and Adenovirus Receptor Activates Inflammatory Response in Human Respiratory Cells
Tamanini, A., Nicolis, E., Bonizzato, A., Bezzerri, V., Melotti, P., Assael, B. M., & Cabrini, G. (2006) · Journal of Virology · doi:10.1128/jvi.00721-06 · Cited by 91
Adenovirus Vector-Induced Inflammation: Capsid-Dependent Induction of the C-C Chemokine RANTES Requires NF- κ B
Bowen, G. P., Borgland, S. L., Lam, M., Libermann, T. A., Wong, N. C. W., & Muruve, D. A. (2002) · Human Gene Therapy · doi:10.1089/10430340252792503 · Cited by 87
Recombinant Adenovirus Vectors Activate the Alternative Complement Pathway, Leading to the Binding of Human Complement Protein C3 Independent of Anti-Ad Antibodies
Jiang, H., Wang, Z., Serra, D. M., Frank, M. M., & Amalfitano, A. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.015 · Cited by 84
Self-citation
Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells
Hartman, Z. C., Black, E. P., & Amalfitano, A. (2006) · Virology · doi:10.1016/j.virol.2006.08.041 · Cited by 81
Self-citation
Murine dendritic cells infected with adenovirus vectors show signs of activation
Hirschowitz, E. A., Weaver, J., Hidalgo, G., & Doherty, D. E. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301210 · Cited by 79
Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity
Kurt‐Jones, E. A., Sandor, F., Ortiz, Y., Bowen, G. N., Counter, S. L., Wang, T. C., & Finberg, R. W. (2004) · Journal of Endotoxin Research · doi:10.1179/096805104225006516 · Cited by 79
Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.
Hensley, S. E., Cun, A. S., Giles-Davis, W., Li, Y., Xiang, Z., Lasaro, M. O., Williams, B. R. G., Silverman, R. H., & Ertl, H. C. J. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300024 · Cited by 78
Preexisting Immunity to Adenovirus in Rhesus Monkeys Fails To Prevent Vector-Induced Toxicity
Varnavski, A. N., Zhang, Y., Schnell, M. A., Tazelaar, J., Louboutin, J., Yu, Q., Bagg, A., Gao, G., & Wilson, J. M. (2002) · Journal of Virology · doi:10.1128/jvi.76.11.5711-5719.2002 · Cited by 78
Dendritic Cell Maturation, but Not CD8+ T Cell Induction, Is Dependent on Type I IFN Signaling during Vaccination with Adenovirus Vectors
Hensley, S. E., Giles‐Davis, W., McCoy, K. C., Weninger, W., & Ertl, H. C. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.6032 · Cited by 73
Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production
Koizumi, N., Yamaguchi, T., Kawabata, K., Sakurai, F., Sasaki, T., Watanabe, Y., Hayakawa, T., & Mizuguchi, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1767 · Cited by 72
Role of Viral Vectors and Virion Shells in Cellular Gene Expression
Stilwell, J. L., & Samulski, R. J. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2003.11.007 · Cited by 67
Adenovirus 5 Fibers Mutated at the Putative HSPG-binding Site Show Restricted Retargeting with Targeting Peptides in the HI Loop
Kritz, A., Nicol, C. G., Dishart, K. L., Nelson, R., Holbeck, S. L., Seggern, D. J. V., Work, L. M., McVey, J. H., Nicklin, S. A., & Baker, A. H. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300094 · Cited by 61
Interference with the IL-1-Signaling Pathway Improves the Toxicity Profile of Systemically Applied Adenovirus Vectors
Shayakhmetov, D. M., Li, Z.-Y., Ni, S., & Lieber, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7310 · Cited by 50
Early-Onset Inflammatory Responses In Vivo to Adenoviral Vectors in the Presence or Absence of Lipopolysaccharide-Induced Inflammation
Thorne, P. S., McCray, P. B., Howe, T. S., & O'Neill, M. A. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3632 · Cited by 49
Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14+ monocytes cultured under serum-free conditions
Lyakh, L. A., Koski, G. K., Young, H. A., Spence, S. E., Cohen, P. A., & Rice, N. R. (2002) · Blood · doi:10.1182/blood.v99.2.600 · Cited by 48
A Replication Competent Adenovirus 5 Host Range Mutant-Simian Immunodeficiency Virus (SIV) Recombinant Priming/Subunit Protein Boosting Vaccine Regimen Induces Broad, Persistent SIV-Specific Cellular Immunity to Dominant and Subdominant Epitopes in Mamu-A*01 Rhesus Macaques
Malkevitch, N., Patterson, L. J., Aldrich, K., Richardson, E. S., Alvord, W. G., & Robert-Guroff, M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4281 · Cited by 47
Effect of Adenovirus Gene Transfer Vectors on the Immunologic Functions of Mouse Dendritic Cells
Korst, R. J., Mahtabifard, A., Yamada, R. E., & Crystal, R. G. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0538 · Cited by 45
Correction of the Nonlinear Dose Response Improves the Viability of Adenoviral Vectors for Gene Therapy of Fabry Disease
Ziegler, R. J., Li, C. Q., Cherry, M., Zhu, Y., Hempel, D. M., van Rooijen, N., Ioannou, Y. A., Desnick, R. J., Goldberg, M. A., Yew, N. S., et al. (2002) · Human Gene Therapy · doi:10.1089/10430340252939041 · Cited by 45
Surfactant Protein A–Polylysine Conjugates for Delivery of DNA to Airway Cells in Culture
Ross, G. F., Morris, R. E., Ciraolo, G. M., Huelsman, K. M., Bruno, M. D., Whitsett, J. A., Baatz, J. E., & Korfhagen, T. R. (1995) · Human Gene Therapy · doi:10.1089/hum.1995.6.1-31 · Cited by 43
Lipid Emulsions Potently Increase Transgene Expression in Hepatocytes after Adenoviral Transfer
Snoeys, J., Mertens, G., Lievens, J., van Berkel, T. J. C., Collen, D., Biessen, E. A. L., & Geest, B. D. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.06.477 · Cited by 42
Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression
Granberg, F., Svensson, C., Pettersson, U., & Zhao, H. (2006) · Virology · doi:10.1016/j.virol.2006.06.019 · Cited by 40
Recombinant Adenoviral Vector Disrupts Surfactant Homeostasis in Mouse Lung
Zsengellér, Z. K., Wert, S. E., Bachurski, C. J., Kirwin, K. L., Trapnell, B. C., & Whitsett, J. A. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.11-1331 · Cited by 35
Akt/Protein Kinase B Activation by Adenovirus Vectors Contributes to NFκB-Dependent CXCL10 Expression
Liu, Q., White, L. R., Clark, S. A., Heffner, D. J., Winston, B. W., Tibbles, L. A., & Muruve, D. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14507-14515.2005 · Cited by 33
Profiling of genes which are differentially expressed in mouse liver in response to adenoviral vectors and delivered genes
Haberberger, T., Kupfer, K., & Murphy, J. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301181 · Cited by 33
Optimization of dendritic cell maturation and gene transfer by recombinant adenovirus
Miller, G., Lahrs, S., Shah, A. B., & DeMatteo, R. P. (2003) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-003-0379-6 · Cited by 32
Mouse Mammary Tumor Virus and the Immune System
Czarneski, J., Rassa, J. C., & Ross, S. R. (2003) · Immunologic Research · doi:10.1385/ir:27:2-3:469 · Cited by 29
Ex Vivo Cultured Megakaryocytes Express Functional Glycoprotein IIb-IIIa Receptors and Are Capable of Adenovirus-Mediated Transgene Expression
Faraday, N. R., Rade, J. J., Johns, D. C., Khetawat, G., Noga, S. J., DiPersio, J. F., Jin, Y. S., Nichol, J. L., Haug, J. S., & Bray, P. F. (1999) · Blood · doi:10.1182/blood.v94.12.4084 · Cited by 29
Efficient Transduction of Human Monocyte-Derived Dendritic Cells by Chimpanzee-Derived Adenoviral Vector
Varnavski, A. N., Schlienger, K., Bergelson, J. M., Gao, G., & Wilson, J. M. (2003) · Human Gene Therapy · doi:10.1089/104303403764539323 · Cited by 26
Identification of Specific Cellular Genes Up-Regulated Late in Adenovirus Type 12 Infection
Dorn, A., Zhao, H., Granberg, F., Hösel, M., Webb, D., Svensson, C., Pettersson, U., & Doerfler, W. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2404-2412.2005 · Cited by 24
Different modulation of cellular transcription by adenovirus 5, ΔE1/E3 adenovirus and helper-dependent vectors
Martina, Y., Avitabile, D., Piersanti, S., Cherubini, G., & Saggio, I. (2007) · Virus Research · doi:10.1016/j.virusres.2007.05.019 · Cited by 12
Retroviral Infection and Selection of Culture-Derived Platelets Allows Study of the Effect of Transgenes on Platelet Physiology Ex Vivo and on Thrombus Formation In Vivo
Gillitzer, A., Peluso, M. V., Laugwitz, K., Münch, G., Maßberg, S., Konrad, I., Gawaz, M., & Ungerer, M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000172659.01157.c6 · Cited by 11
Gene Expression Changes Induced by a Recombinant E1–/E3– Adenovirus Type 5 Vector in Human Mammary Epithelial Cells
Scibetta, A. G., Copier, J. P., Barrett, A. N., Chaplin, T., & Taylor‐Papadimitriou, J. (2005) · Intervirology · doi:10.1159/000086062 · Cited by 11
A Study of Events in Chick Cells Infected with Human Adenovirus Type 5 and their Relationship to the Induction of Interferon
Tarodi, B., Metz, D. H., Douglas, A., & Russell, W. C. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-3-425 · Cited by 10
Employment of microarray analysis to characterize biologic differences associated with tropism-modified adenoviral vectors: utilization of non-native cellular entry pathways
Volk, A. L., Rivera, Á. A., Page, G. P., Salazar-Gonzalez, J. F., Nettelbeck, D. M., Matthews, Q. L., & Curiel, D. T. (2004) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700776 · Cited by 8

Sorted by citations

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Sadarangani, M., Marchant, A., & Kollmann, T. R. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00578-z · Cited by 560
The soil pH and heavy metals revealed their impact on soil microbial community
Naz, M., Dai, Z., Hussain, S., Tariq, M., Danish, S., Khan, I. U., Qi, S., & Du, D. (2022) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.115770 · Cited by 535
Adenoviruses: update on structure and function
Russell, W. C. (2008) · Journal of General Virology · doi:10.1099/vir.0.003087-0 · Cited by 462
Adenovirus: The First Effective In Vivo Gene Delivery Vector
Crystal, R. G. (2014) · Human Gene Therapy · doi:10.1089/hum.2013.2527 · Cited by 348
Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth
Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337

See all 239

Authors: Hartman, Z. C., Appledorn, D. M., & Amalfitano, A.
Affiliations: Duke Medical Center (US)
Michigan State University (US)
Corresponding author: Amalfitano, Andrea
ORCID: Hartman, Zachary C.
Venue: Virus Research
Publisher: Elsevier BV
Published: 2008-03
Volume: 132
Issue: 1-2
Pages: 1-14
ISSN: 0168-1702 (ISSN-L)
DOI: 10.1016/j.virusres.2007.10.005
PMC: PMC4039020
OpenAlex: W2075338937
Cited by: 239
References: 101
Citations by year: 2026: 7 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 14 · 2016: 3 · 2015: 11 · 2014: 14 · 2013: 17 · 2012: 15
FWCI: 2.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Virus Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (P01CA078673, CA078673)
National Institute of Diabetes and Digestive and Kidney Diseases (DK069884, R01DK069884)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: adenoviral vector, innate immune response, gene therapy, vaccine development, adjuvants, immune evasion, gene delivery vectors, vector toxicity
MeSH terms: Adenoviridae, Animals, Genetic Vectors, Humans, Immunity, Innate, Receptors, Virus, Viral Vaccines, Genetic Therapy, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks