Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Hacein-Bey-Abina, S., Garrigue, A., Wang, G. P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35700 · Cited by 1,854 · see citing works

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works

Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742 · see citing works

Functional delivery of viral miRNAs via exosomes

Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Wurdinger, T. D., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,648 · see citing works

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643 · see citing works

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works

Exosomal-like vesicles are present in human blood plasma

Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348 · see citing works

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

Montecalvo, A., Larregina, A. T., Shufesky, W. J., Beer Stolz, D., Sullivan, M. L. G., Karlsson, J. M., Baty, C. J., Gibson, G. A., Erdos, G., Wang, Z., et al. (2012) · Blood · doi:10.1182/blood-2011-02-338004 · Cited by 1,262 · see citing works

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

Balaj, L., Lessard, R., Dai, L., Cho, Y., Pomeroy, S. L., Breakefield, X. O., & Skog, J. (2011) · Nature Communications · doi:10.1038/ncomms1180 · Cited by 1,185 · see citing works

Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution

Dobrovolskaia, M. A., Aggarwal, P., Hall, J. B., & McNeil, S. E. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800032f · Cited by 1,022 · see citing works

Exosomes: A Common Pathway for a Specialized Function

van Niel, G., Porto-Carreiro, I., Simoes, S., & Raposo, G. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj128 · Cited by 922 · see citing works

Exosomes: From biogenesis and secretion to biological function

Keller, S., Sanderson, M. P., Stoeck, A., & Altevogt, P. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.09.005 · Cited by 856 · see citing works

The Biogenesis and Functions of Exosomes

Stoorvogel, W., Kleijmeer, M. J., Geuze, H. J., & Raposo, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30502.x · Cited by 848 · see citing works

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., & Hivroz, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3235 · Cited by 660 · see citing works

The dsRNA protein kinase PKR: Virus and cell control

García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644 · see citing works

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

Huber, B. E., Austin, E. A., Richards, C. A., Davis, S. T., & Good, S. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8302 · Cited by 420 · see citing works

Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles

Yuan, A., Farber, E. L., Rapoport, A. L., Tejada, D., Deniskin, R., Akhmedov, N. B., & Farber, D. B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004722 · Cited by 416 · see citing works

Exosomes biological significance: A concise review

Johnstone, R. M. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.12.001 · Cited by 339 · see citing works

Biological gene delivery vehicles: beyond viral vectors.

Seow, Y., & Wood, M. (2009) · Molecular Therapy · doi:10.1038/mt.2009.41 · Cited by 339 · see citing works

SiRNA delivery with exosome nanoparticles.

van den Boorn, J. G., Schlee, M., Coch, C., & Hartmann, G. (2011) · Nature Biotechnology · doi:10.1038/nbt.1830 · Cited by 329 · see citing works

Nanomaterials for Cancer Therapy and Imaging

Bae, K. H., Chung, H. J., & Park, T. G. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0051-5 · Cited by 312 · see citing works

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

Bolukbasi, M. F., Mizrak, A., Ozdener, G. B., Madlener, S., Ströbel, T., Erkan, E. P., Fan, J., Breakefield, X. O., & Saydam, O. (2012) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2011.2 · Cited by 290 · see citing works

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

Maguire, C. A., Balaj, L., Sivaraman, S., Crommentuijn, M. H., Ericsson, M., Mincheva-Nilsson, L., Baranov, V., Gianni, D., Tannous, B. A., Sena-Esteves, M., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2011.303 · Cited by 283 · see citing works

Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors

Shen, B., Wu, N., Yang, J.-M., & Gould, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208660 · Cited by 283 · see citing works

Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway

Saydam, O., Shen, Y., Würdinger, T., Senol, O., Böke, E., James, M. F., Tannous, B. A., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00332-09 · Cited by 254 · see citing works

PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR

Patel, C. V., Handy, I., Goldsmith, T., & Patel, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004762200 · Cited by 247 · see citing works

Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.

Hartman, Z. C., Appledorn, D. M., & Amalfitano, A. (2008) · Virus Research · doi:10.1016/j.virusres.2007.10.005 · Cited by 239 · see citing works

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

Mullen, C. A., Coale, M. M., Lowe, R., & Blaese, R. M. (1994) · PubMed · Cited by 223 · see citing works

Exosomes Derived from Genetically Modified DC Expressing FasL Are Anti-inflammatory and Immunosuppressive

Kim, S. H., Bianco, N. R., Menon, R., Lechman, E. R., Shufesky, W. J., Morelli, A. E., & Robbins, P. D. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.09.015 · Cited by 217 · see citing works

Immune Responses to Adeno-Associated Virus Vectors

Zaiss, A. K., & Muruve, D. A. (2005) · Current Gene Therapy · doi:10.2174/1566523054065039 · Cited by 214 · see citing works

In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene.

Erbs, P., Régulier, E., Kintz, J., Leroy, P., Poitevin, Y., Exinger, F., Jund, R., & Mehtali, M. (2000) · PubMed · Cited by 202 · see citing works

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

ZHANG, J., LIU, F., & Huang, L. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.004 · Cited by 195 · see citing works

Glioma therapy and real‐time imaging of neural precursor cell migration and tumor regression

Shah, K., Bureau, E. A., Kim, D., Yang, K. S., Tang, Y., Weissleder, R., & Breakefield, X. O. (2004) · Annals of Neurology · doi:10.1002/ana.20306 · Cited by 183 · see citing works

miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways

Saydam, O., Senol, O., Wurdinger, T. D., Mizrak, A., Ozdener, G. B., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., Krichevsky, A. M., Saydam, N., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1219 · Cited by 147 · see citing works

The state of the art of adeno-associated virus-based vectors in gene therapy

Coura, R., & Nardi, N. B. (2007) · Virology Journal · doi:10.1186/1743-422x-4-99 · Cited by 130 · see citing works

Meningioma Transcript Profiles Reveal Deregulated Notch Signaling Pathway

Cuevas, I., Slocum, A. L., Jun, P., Costello, J., Bollen, A. W., Riggins, G. J., McDermott, M. W., & Lal, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0240 · Cited by 112 · see citing works

Brain Tumor Microvesicles: Insights into Intercellular Communication in the Nervous System

van der Vos, K. E., Balaj, L., Skog, J., & Breakefield, X. O. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9697-y · Cited by 103 · see citing works

Establishment and characterization of a schwannoma cell line from a patient with neurofibromatosis 2

Hung, G., Li, X., Faudoa, R., Xeu, Z., Kluwe, L., Rhim, J. S., Slattery, W. H., & LIM, D. J. (2002) · International Journal of Oncology · doi:10.3892/ijo.20.3.475 · Cited by 65 · see citing works

Urinary exosomes: is there a future?

Gonzales, P., Pisitkun, T., & Knepper, M. A. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn058 · Cited by 62 · see citing works

Development of gene drug delivery systems based on pharmacokinetic studies

Takakura, Y., Nishikawa, M., Yamashita, F., & Hashida, M. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00209-8 · Cited by 53 · see citing works

Early shutoff of host protein synthesis in cells infected with herpes simplex viruses.

Matis, J., & Kúdelová, M. (2001) · PubMed · Cited by 50 · see citing works

A novel imaging-compatible sciatic nerve schwannoma model

Saydam, O., Ozdener, G. B., Senol, O., Mizrak, A., Prabhakar, S., Stemmer-Rachamimov, A. O., Breakefield, X. O., & Brenner, G. J. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.10.021 · Cited by 20 · see citing works

Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter

Prabhakar, S., Brenner, G. J., Sung, B., Messerli, S. M., Mao, J., Sena‐Esteves, M., Stemmer-Rachamimov, A. O., Tannous, B. A., & Breakefield, X. O. (2009) · Cancer Gene Therapy · doi:10.1038/cgt.2009.71 · Cited by 19 · see citing works

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works

New Technologies for Analysis of Extracellular Vesicles

Shao, H., Im, H., Castro, C. M., Breakefield, X. O., Weissleder, R., & Lee, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00534 · Cited by 1,672 · see citing works

Extracellular vesicles in cancer — implications for future improvements in cancer care

Xu, R., Rai, A., Chen, M., Suwakulsiri, W., Greening, D. W., & Simpson, R. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0036-9 · Cited by 1,435 · see citing works

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323 · see citing works

Extracellular vesicles for drug delivery.

Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,237 · see citing works

Nanomaterials for cancer therapy: current progress and perspectives

Cheng, Z., Li, M., Dey, R., & Chen, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01096-0 · Cited by 1,193 · see citing works

Advances in therapeutic applications of extracellular vesicles

Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & EL Andaloussi, S. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav8521 · Cited by 1,039 · see citing works

Exosomes: Therapy delivery tools and biomarkers of diseases

Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,038 · see citing works

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 894 · see citing works

Innovative approaches for cancer treatment: current perspectives and new challenges

Pucci, C., Martinelli, C., & Ciofani, G. (2019) · ecancermedicalscience · doi:10.3332/ecancer.2019.961 · Cited by 832 · see citing works

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704 · see citing works

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

Saari, H., Lázaro-Ibáñez, E., Viitala, T., Vuorimaa-Laukkanen, E., Siljander, P., & Yliperttula, M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.031 · Cited by 613 · see citing works

Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics

Armstrong, J. P. K., Holme, M. N., & Stevens, M. M. (2017) · ACS Nano · doi:10.1021/acsnano.6b07607 · Cited by 605 · see citing works

Biology and biogenesis of shed microvesicles

Tricarico, C. J., Clancy, J. W., & D’Souza‐Schorey, C. (2016) · Small GTPases · doi:10.1080/21541248.2016.1215283 · Cited by 588 · see citing works

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

Li, X., Corbett, A. L., Taatizadeh, E., Tasnim, N., Little, J. P., Garnis, C., Daugaard, M., Guns, E. S. T., Hoorfar, M., & Li, I. T. S. (2019) · APL Bioengineering · doi:10.1063/1.5087122 · Cited by 575 · see citing works

The biology, function, and applications of exosomes in cancer

Liu, J., Ren, L., Li, S., Li, W., Zheng, X., Yang, Y., Fu, W., Yi, J., Wang, J., & Du, G. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.001 · Cited by 564 · see citing works

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

György, B., Hung, M. E., Breakefield, X. O., & Leonard, J. N. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124630 · Cited by 512 · see citing works

Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing

Didiot, M.-C., Hall, L. M., Coles, A. H., Haraszti, R. A., Godinho, B. M., Chase, K., Sapp, E., Ly, S., Alterman, J. F., Hassler, M. R., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.126 · Cited by 483 · see citing works

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

van der Meel, R., Fens, M. H. A. M., Vader, P., van Solinge, W. W., Eniola‐Adefeso, O., & Schiffelers, R. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.049 · Cited by 486 · see citing works

Differential fates of biomolecules delivered to target cells via extracellular vesicles

Kanada, M., Bachmann, M. H., Hardy, J. W., Frimannson, D. O., Bronsart, L. L., Wang, A., Sylvester, M. D., Schmidt, T. L., Kaspar, R. L., Butte, M. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418401112 · Cited by 467 · see citing works

Engineered Extracellular Vesicles for Cancer Therapy

Zhang, X., Zhang, H., Gu, J., Zhang, J., Shi, H., Qian, H., Wang, D., Xu, W., Pan, J., & Santos, H. A. (2021) · Advanced Materials · doi:10.1002/adma.202005709 · Cited by 428 · see citing works

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

Ferguson, S. W., & Nguyen, J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.037 · Cited by 419 · see citing works

The challenge and prospect of mRNA therapeutics landscape

Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., & Huang, Y. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107534 · Cited by 417 · see citing works

Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges

Syn, N. L. X., Wang, L., Chow, E. K., Lim, C. T., & Goh, B.-C. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.03.004 · Cited by 399 · see citing works

Multiplexed Profiling of Single Extracellular Vesicles

Lee, K., Fraser, K. B., Ghaddar, B., Yang, K. S., Kim, E., Balaj, L., Chiocca, E. A., Breakefield, X. O., Lee, H., & Weissleder, R. (2017) · ACS Nano · doi:10.1021/acsnano.7b07060 · Cited by 362 · see citing works

Extracellular vesicles: A bright star of nanomedicine

Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368 · see citing works

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

Hung, M. E., & Leonard, J. N. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621383 · Cited by 368 · see citing works

Exosomes derived from miR‐375‐overexpressing human adipose mesenchymal stem cells promote bone regeneration

Chen, S., Tang, Y., Liu, Y., Zhang, P., Lv, L., Zhang, X., Jia, L., & Zhou, Y. (2019) · Cell Proliferation · doi:10.1111/cpr.12669 · Cited by 344 · see citing works

Engineered Exosomes as Vehicles for Biologically Active Proteins

Sterzenbach, U., Putz, U., Low, L., Silke, J., Tan, S., & Howitt, J. A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.030 · Cited by 341 · see citing works

Non-viral vectors for RNA delivery

Yan, Y., Liu, X.-Y., Lu, A., Wang, X.-Y., Jiang, L.-X., & Wang, J.-C. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.008 · Cited by 332 · see citing works

Milk exosomes - Natural nanoparticles for siRNA delivery

Aqil, F., Munagala, R., Jeyabalan, J., Agrawal, A. K., Kyakulaga, A.-H., Wilcher, S. A., & Gupta, R. C. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.02.011 · Cited by 315 · see citing works

The Exosome ‐ A Naturally Secreted Nanoparticle and its Application to Wound Healing

Rani, S., & Ritter, T. (2015) · Advanced Materials · doi:10.1002/adma.201504009 · Cited by 295 · see citing works

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

Han, L., Lam, E. W. ‐., & Sun, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0980-8 · Cited by 295 · see citing works

Engineering Exosomes for Cancer Therapy

Gilligan, K., & Dwyer, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061122 · Cited by 290 · see citing works

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

Rädler, J., Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.02.013 · Cited by 292 · see citing works

Rational Design of Nanocarriers for Intracellular Protein Delivery

Qin, X., Yu, C., Wei, J., Li, L., Zhang, C., Wu, Q., Liu, J., Yao, S. Q., & Huang, W. (2019) · Advanced Materials · doi:10.1002/adma.201902791 · Cited by 281 · see citing works

Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair

Bjørge, I. M., Kim, S. Y., Mano, J. F., Kalionis, B., & Chrzanowski, W. (2017) · Biomaterials Science · doi:10.1039/c7bm00479f · Cited by 276 · see citing works

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N. J., Popowski, K. D., & Cheng, K. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01580-3 · Cited by 276 · see citing works

Strategic design of extracellular vesicle drug delivery systems

Armstrong, J. P. K., & Stevens, M. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.017 · Cited by 265 · see citing works

Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers

Das, C. K., Jena, B. C., Banerjee, I., Das, S., Parekh, A., Bhutia, S. K., & Mandal, M. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00901 · Cited by 264 · see citing works

M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization

Li, H., Feng, Y., Zheng, X. C., Jia, M., Mei, Z., Wang, Y., Zhang, Z., Zhou, M., & Li, C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.019 · Cited by 265 · see citing works

Extracellular vesicles and intercellular communication within the nervous system

Zappulli, V., Friis, K. P., Fitzpatrick, Z., Maguire, C. A., & Breakefield, X. O. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81134 · Cited by 252 · see citing works

A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery

Hung, M. E., & Leonard, J. N. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31027 · Cited by 251 · see citing works

The biology of extracellular microvesicles

Sedgwick, A., & D’Souza‐Schorey, C. (2018) · Traffic · doi:10.1111/tra.12558 · Cited by 246 · see citing works

Tumor-derived exosomes in cancer progression and treatment failure

Yu, S., Cao, H., Shen, B., & Feng, J. (2015) · Oncotarget · doi:10.18632/oncotarget.6022 · Cited by 215 · see citing works

Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications

Shi, Y., Shi, M., Wáng, Y., & You, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02002-z · Cited by 231 · see citing works

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

de Castilla, P. E. M., Tong, L., Huang, C., Sofias, A. M., Pastorin, G., Chen, X. S., Storm, G., Schiffelers, R. M., & Wang, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.011 · Cited by 214 · see citing works

Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives

Butreddy, A., Kommineni, N., & Dudhipala, N. R. (2021) · Nanomaterials · doi:10.3390/nano11061481 · Cited by 214 · see citing works

Overview and Update on Methods for Cargo Loading into Extracellular Vesicles

Han, Y., Jones, T. W., Dutta, S., Zhu, Y., Wang, X., Narayanan, S. P., Fagan, S. C., & Zhang, D. (2021) · Processes · doi:10.3390/pr9020356 · Cited by 213 · see citing works

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

Erel‐Akbaba, G., de Carvalho, L. A., Tian, T., Zinter, M., Akbaba, H., Obeid, P. J., Chiocca, E. A., Weissleder, R., Kantarcı, A. G., & Tannous, B. A. (2019) · ACS Nano · doi:10.1021/acsnano.8b08177 · Cited by 205 · see citing works

FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver

Marcus, M., & Leonard, J. N. (2013) · Pharmaceuticals · doi:10.3390/ph6050659 · Cited by 201 · see citing works

Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics

Rodrigues, M., Fan, J., Lyon, C., Wan, M., & Hu, Y. (2018) · Theranostics · doi:10.7150/thno.20576 · Cited by 191 · see citing works

Exosome: a significant nano-scale drug delivery carrier

Peng, H., Ji, W., Zhao, R., Yang, J., Lü, Z., Li, Y., & Zhang, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01499k · Cited by 189 · see citing works

Therapeutic and diagnostic applications of extracellular vesicles

Stremersch, S., Smedt, S. C. D., & Raemdonck, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.054 · Cited by 187 · see citing works

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

Koniusz, S., Andrzejewska, A., Muraca, M., Srivastava, A. K., Janowski, M., & Łukomska, B. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00109 · Cited by 184 · see citing works

Exosomes: cell-created drug delivery systems

Familtseva, A., Jeremic, N. S., & Tyagi, S. C. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03545-4 · Cited by 185 · see citing works

Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles

Jeyaram, A., Lamichhane, T. N., Wang, S., Zou, L., Dahal, E., Kronstadt, S. M., Levy, D. H., Parajuli, B., Knudsen-Palmer, D. R., Chao, W., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.12.007 · Cited by 184 · see citing works

Technological advances towards extracellular vesicles mass production

Grangier, A., Branchu, J., Volatron, J., Piffoux, M., Gazeau, F., Wilhelm, C., & Silva, A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113843 · Cited by 175 · see citing works

Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications

Kao, C., & Papoutsakis, E. T. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.01.005 · Cited by 167 · see citing works

Recent Advances in Anti-cancer Protein/Peptide Delivery

Liu, X., Wu, F., Ji, Y. I., & Yin, L. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00750 · Cited by 161 · see citing works

Large Extracellular Vesicles: Have We Found the Holy Grail of Inflammation?

Słomka, A., Urban, S. K., Kornek, M., Żekanowska, E., & Kornek, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02723 · Cited by 160 · see citing works

Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?

Mirzaei, H., Sahebkar, A., Jaafari, M. R., Goodarzi, M., & Mirzaei, H. R. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25739 · Cited by 155 · see citing works

Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges

Fuhrmann, G., Herrmann, I. K., & Stevens, M. M. (2015) · Nano Today · doi:10.1016/j.nantod.2015.04.004 · Cited by 155 · see citing works

Natural and synthetic nanovectors for cancer therapy

Eftekhari, A., Kryschi, C., Pamies, D., Güleç, Ş., Ahmadian, E., Janas, D. W., Davaran, S., & Khalilov, R. I. (2023) · Nanotheranostics · doi:10.7150/ntno.77564 · Cited by 154 · see citing works

Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies

Wang, K., Kievit, F. M., & Zhang, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.10.016 · Cited by 152 · see citing works

Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

Jiang, L., Vader, P., & Schiffelers, R. M. (2017) · Gene Therapy · doi:10.1038/gt.2017.8 · Cited by 150 · see citing works

Exosome for mRNA delivery: Strategies and therapeutic applications

Iqbal, Z., Rehman, K., Mahmood, A., Shabbir, M., Liang, Y., Duan, L., & Zeng, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02634-x · Cited by 144 · see citing works

Emerging roles and therapeutic value of exosomes in cancer metastasis

Wu, M., Wang, G., Hu, W., Yao, Y., & Yu, X.-F. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0964-8 · Cited by 140 · see citing works

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

Sutaria, D. S., Badawi, M., Phelps, M. A., & Schmittgen, T. D. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2123-5 · Cited by 140 · see citing works

Emerging roles of extracellular vesicles in neurodegenerative disorders

You, Y., & Ikezu, T. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104512 · Cited by 133 · see citing works

The extracellular vesicles‐derived from mesenchymal stromal cells: A new therapeutic option in regenerative medicine

Nooshabadi, V. T., Mardpour, S., Yousefi‐Ahmadipour, A., Allahverdi, A., Izadpanah, M., Daneshimehr, F., Ai, J., Banafshe, H. R., & Ebrahimi‐Barough, S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26726 · Cited by 133 · see citing works

Epigenetic Regulation of Oxidative Stress in Ischemic Stroke

Zhao, H., Han, Z., Ji, X., & Luo, Y. (2016) · Aging and Disease · doi:10.14336/ad.2015.1009 · Cited by 131 · see citing works

Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations

Klyachko, N. L., Arzt, C. J., Li, S. M., Gololobova, O. A., & Batrakova, E. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121171 · Cited by 132 · see citing works

Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments

Jaiswal, R., & Sedger, L. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00125 · Cited by 131 · see citing works

Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment

Bu, T., Li, Z., Hou, Y., Sun, W., Zhang, R., Zhao, L., Wei, M., Yang, G., & Yuan, L. (2021) · Theranostics · doi:10.7150/thno.64229 · Cited by 128 · see citing works

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

Zhu, Q., Heon, M., Zhao, Z., & He, M. (2018) · Lab on a Chip · doi:10.1039/c8lc00246k · Cited by 127 · see citing works

Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies

Mehdizadeh, S., Mamaghani, M., Hassanikia, S., Pilehvar‐Soltanahmadi, Y., & Ertaş, Y. N. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03352-8 · Cited by 124 · see citing works

Targeting the blood-brain barrier for the delivery of stroke therapies

D’souza, A. A., Dave, K. M., Stetler, R. A., & Manickam, D. S. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.015 · Cited by 122 · see citing works

A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice

Gangadaran, P., Li, X. J., Lee, H., Oh, J. M., Kalimuthu, S., Rajendran, R. L., Son, S. H., Baek, S. H., Singh, T. D., Zhu, L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22493 · Cited by 121 · see citing works

Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance

Liu, J., Ye, Z., Xiang, M., Chang, B., Cui, J., Ji, T., Zhao, L., Li, Q., Deng, Y., Xu, L., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119475 · Cited by 121 · see citing works

Nucleic acid delivery with extracellular vesicles

Schulz‐Siegmund, M., & Aigner, A. M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.005 · Cited by 121 · see citing works

Designer exosomes as next-generation cancer immunotherapy

Bell, B. M., Kirk, I. D., Hiltbrunner, S., Gabrielsson, S., & Bultema, J. J. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.09.011 · Cited by 120 · see citing works

A Comprehensive Picture of Extracellular Vesicles and Their Contents. Molecular Transfer to Cancer Cells

Jurj, A. M., Zănoagă, O., Braicu, C., Lazar, V., Tomuleasa, C., Irimie, A., & Berindan‐Neagoe, I. (2020) · Cancers · doi:10.3390/cancers12020298 · Cited by 116 · see citing works

The role of extracellular vesicles in the progression of neurodegenerative disease and cancer

Candelario, K. M., & Steindler, D. A. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.04.003 · Cited by 112 · see citing works

Exosomes and their Application in Biomedical Field: Difficulties and Advantages

Rezaie, J., Ajezi, S., Avcı, Ç. B., Karimipour, M., Geranmayeh, M. H., Nourazarian, A., Sokullu, E., Rezabakhsh, A., & Rahbarghazi‬, R. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0582-7 · Cited by 116 · see citing works

Engineered Cas9 extracellular vesicles as a novel gene editing tool

Osteikoetxea, X., da Silva, A. M., Lázaro‐Ibáñez, E., Salmond, N., Shatnyeva, O., Stein, J., Schick, J., Wren, S. A. C., Lindgren, J., Firth, M. A., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12225 · Cited by 114 · see citing works

Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

Gangadaran, P., Hong, C. M., & Ahn, B. (2017) · BioMed Research International · doi:10.1155/2017/9158319 · Cited by 109 · see citing works

A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy

Li, J., Zhang, Y., Dong, P.-Y., Yang, G.-M., & Gurunathan, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115087 · Cited by 111 · see citing works

The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications

Jabalee, J., Towle, R. M., & Garnis, C. (2018) · Cells · doi:10.3390/cells7080093 · Cited by 109 · see citing works

Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope

Aslan, C., Kiaie, S. H., Zolbanin, N. M., Lotfinejad, P., Ramezani, R., Kashanchi, F., & Jafari, R. (2021) · BMC Biotechnology · doi:10.1186/s12896-021-00683-w · Cited by 111 · see citing works

Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson’s Disease, Glioma, and Schwannoma

Hall, J. S., Prabhakar, S., Balaj, L., Lai, C. P., Cerione, R. A., & Breakefield, X. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0309-0 · Cited by 109 · see citing works

Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs

Zocco, D., Ferruzzi, P., Cappello, F., Kuo, W. P., & Fais, S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00267 · Cited by 105 · see citing works

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Sutaria, D. S., Jiang, J., Elgamal, O. A., Pomeroy, S. M., Badawi, M. A., Zhu, X., Pavlovicz, R. E., Azevedo‐Pouly, A. C. P., Chalmers, J. J., Li, C., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1333882 · Cited by 104 · see citing works

Exosomes in diagnosis and therapy of prostate cancer

Pan, J., Ding, M., Xu, K., Yang, C., & Mao, L. (2017) · Oncotarget · doi:10.18632/oncotarget.18532 · Cited by 103 · see citing works

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Susa, F., Limongi, T., Dumontel, B., Vighetto, V., & Cauda, V. (2019) · Cancers · doi:10.3390/cancers11121979 · Cited by 100 · see citing works

Kinetics and Specificity of HEK293T Extracellular Vesicle Uptake using Imaging Flow Cytometry

Jurgielewicz, B. J., Yao, Y., & Stice, S. L. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03399-6 · Cited by 103 · see citing works

Regulation and mechanisms of extracellular vesicle biogenesis and secretion

D’Souza‐Schorey, C., & Schorey, J. S. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170078 · Cited by 102 · see citing works

The biological functions and clinical applications of exosomes in lung cancer

Chen, R., Xu, X., Qian, Z., Zhang, C., Niu, Y., Wang, Z., Sun, J., Zhang, X., & Yu, Y. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03233-y · Cited by 104 · see citing works

Nanoparticles in pregnancy: the next frontier in reproductive therapeutics

Pritchard, N., Kaitu’u‐Lino, T. J., Harris, L. K., Tong, S., & Hannan, N. J. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa049 · Cited by 101 · see citing works

Extracellular vesicle-mediated suicide mRNA/protein delivery inhibits glioblastoma tumor growth in vivo

Erkan, E. P., Senfter, D., Madlener, S., Jungwirth, G., Ströbel, T., Saydam, N., & Saydam, O. (2016) · Cancer Gene Therapy · doi:10.1038/cgt.2016.78 · Cited by 52 · see citing works

Extracellular Vesicles as Carriers of Suicide mRNA and/or Protein in Cancer Therapy

Erkan, E. P., Saydam, N., Chen, C. C., & Saydam, O. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8922-5_7 · Cited by 7 · see citing works

Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy

Wang, D., Gao, R., Liu, D., Li, K., Wang, R. F., Xu, M., Zhang, S., Jiang, S., & Xia, B. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70299

Abstract 1977: Therapeutic miRNAs targeted selectively to tumors by mesenchymal stem cell derived microparticles

Prokopi, M., Epenetos, A. A., Anayiotos, A. S., Pitsillides, C. M., Kapnisis, K. K., & Kousparou, C. A. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-1977 · Cited by 1 · see citing works

Tumor-targeted suicide gene-directed enzyme prodrug therapy mediated by extracellular vesicles

Jakubechova, J., Altanerova, U., & Altaner, Č. (2023) · Neoplasma · doi:10.4149/neo_2023_230328n172 · Cited by 6 · see citing works