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Cited by 31Bat Biology and Ecology StudiesChromosomal and Genetic VariationsGenetic diversity and population structure

Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation

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Foley, Nicole M., Harris, Andrew J., Bredemeyer, Kevin R., Ruedi, Manuel, Puechmaille, Sebastien J., Teeling, Emma C., Criscitiello, Michael F., Murphy, William J.·2024·Cell Genomics
DOI 10.1016/j.xgen.2023.100482PMC PMC10879000
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Abstract

The emergence of COVID-19 and severe acute respiratory syndrome (SARS) has prioritized understanding bats' viral tolerance. Myotis bats are exceptionally species rich and have evolved viral tolerance. They also exhibit swarming, a cryptic behavior where large, multi-species assemblages gather for mating, which has been hypothesized to promote interspecific hybridization. To resolve the coevolution of genome architecture and their unusual antiviral tolerance, we undertook a phylogenomic analysis of 60 Old World Myotis genomes. We demonstrate an extensive history of introgressive hybridization that has replaced the species phylogeny across 17%-93% of the genome except for pericentromeric regions of macrochromosomes. Introgression tracts were enriched on microchromosome regions containing key antiviral pathway genes overexpressed during viral challenge experiments. Together, these results suggest that the unusual Myotis karyotype may have evolved to selectively position immune-related genes in high recombining genomic regions prone to introgression of divergent alleles, including a diversity of interleukin loci responsible for the release of pro-inflammatory cytokines.

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  • Some mammal species appear capable of retaining phenotypic and ecological distinctiveness from related species even in the face of substantial introgressive hybridization (e.g., mustelids, felids, bats).

    “Some mammal species appear capable of retaining phenotypic and ecological distinctiveness from related species even in the face of substantial introgressive hybridization (e.g., mustelids, felids, bats; Li et al. 2019; Colella et al. 2021; Foley et al. 2024).”

    From How many mammal species are there now? Updates and trends in taxonomic, nomenclatural, and geographic knowledge (2025) · cites this paper as Foley et al. 2024

    The Results section (‘A link between introgression and swarming behavior?’; page unavailable) reports exceptionally pervasive introgression among distinct Myotis bat species, including species from divergent clades. It does not establish that those species retain phenotypic and ecological distinctiveness despite that introgression. The other mammal examples have separate citations and are not attributed to Foley et al. alone. (LLM, conf=0.84)

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  • 17% to 93% of the genomes of European Myotis bats apparently have introgressive origins, suggesting that many genomic regions can be freely exchanged as long as certain other regions are conserved, protecting the distinctiveness of a given species.

    “Consistent with this finding is the observation that 17% to 93% of the genomes of European Myotis bats apparently have introgressive origins (Foley et al. 2024), suggesting that many genomic regions can be freely exchanged as long as certain other regions are conserved, protecting the distinctiveness of a given species.”

    From How many mammal species are there now? Updates and trends in taxonomic, nomenclatural, and geographic knowledge (2025) · cites this paper as Foley et al. 2024

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Cited by

Sorted by citations

Authors
Foley, N. M., Harris, A. J., Bredemeyer, K. R., Ruedi, M., Puechmaille, S. J., Teeling, E. C., Criscitiello, M. F., & Murphy, W. J.
Affiliations
  • Texas A&M University (US)
  • University College Dublin (IE)
Corresponding author
  • Foley, Nicole M.
  • Murphy, William J.
ORCID
Venue
Cell Genomics
Publisher
Elsevier BV
Published
2024-02
Volume
4
Issue
2
Pages
100482
ISSN
2666-979X (ISSN-L)
DOI
10.1016/j.xgen.2023.100482
PMC
PMC10879000
OpenAlex
W4390942256
Cited by
31
References
5
Citations by year
2026: 12 · 2025: 13 · 2024: 6
FWCI
11.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Genomics (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Science Foundation Ireland (19/FFP/6790)
  • Irish Research Council (IRCLA/2017/58)
  • National Science Foundation (DEB-1753760, DEB-2150664)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Bat Biology and Ecology Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords
Myotis, bats, virus tolerance, karyotype evolution, swarming, introgression, genome organization, antiviral immunity, cytokine genes, microchromosomes, pericentromeric regions, phylogenomics
MeSH terms
Animals, Antiviral Agents, Chiroptera, Genome, Genomics, Karyotype

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