The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Maintenance of mouse trophoblast stem cell proliferation by TGF-β/activin
Open accessAbstract
Mouse trophoblast stem (TS) cells can be grown indefinitely in vitro with FGF4 and embryonic fibroblast conditioned media (EFCM). Here, we report that the active protein components of EFCM include TGF-beta and the related factor activin, and that long-term continuous TS cell proliferation is possible in media supplemented with only serum, FGF4, and TGF-beta. As trophoblasts are an epithelial cell type, the promotion of TS cell proliferation represents an unusual function for TGF-beta and activin since TGF-beta in particular is well known as an inhibitor of nontransformed epithelial cell proliferation. Our data suggest that constitutive FGF signaling in TS cells selectively inhibits the ability of TGF-beta to repress c-myc expression, a central component of the TGF-beta cytostatic transcriptional response previously observed to be lost in other epithelial cell types upon oncogenic Ras transformation.
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Cites
Functional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578
Liu, D., Black, B. L., & Derynck, R. (2001) · Genes & Development · doi:10.1101/gad.925901 · Cited by 399
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
Corson, L. B., Yamanaka, Y., Lai, K.-M. V., & Rossant, J. (2003) · Development · doi:10.1242/dev.00669 · Cited by 390
Choy, L., & Derynck, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212259200 · Cited by 343
Cited by
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Maltepe, E., & Fisher, S. J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125620 · Cited by 592
Endogenous retroviruses function as species-specific enhancer elements in the placenta
Chuong, E. B., Rumi, M. A. K., Soares, M. J., & Baker, J. C. (2013) · Nature Genetics · doi:10.1038/ng.2553 · Cited by 429
Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta
Simmons, D. G., Fortier, A. L., & Cross, J. C. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.009 · Cited by 398
Clinical and therapeutic implications of follistatin in solid tumours
SHI, L., RESAUL, J., OWEN, S., YE, L., & JIANG, W. G. (2016) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20005 · Cited by 47
Metadata
- Authors
- Erlebacher, A., Price, K. A., & Glimcher, L. H.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 275
- Issue
- 1
- Pages
- 158-169
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1970062529
- Cited by
- 184
- References
- 4
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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