The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
Open accessAbstract
Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1 progenitors have migrated into the heart by E9. Although Isl1 expression is downregulated in most cardiac progenitors as they differentiate, analysis of an isl1-nlacZ mouse and coimmunostaining for Isl1 and lineage markers demonstrated that Isl1 is expressed in distinct subdomains of the heart, and in diverse cardiovascular lineages. Isl1 expression was observed in myocardial lineages of the distal outflow tract, atrial septum, and in sinoatrial and atrioventricular node. The myocardialized septum of the outflow tract was found to derive from Isl1 expressing cells. Isl1 expressing cells also contribute to endothelial and vascular smooth muscle lineages including smooth muscle of the coronary vessels. Our data indicate that Isl1 is a specific marker for a subset of pacemaker cells at developmental stages examined, and suggest genetic heterogeneity within the central conduction system and coronary smooth muscle. Our studies suggest a role for Isl1 in these distinct domains of expression within the heart.
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Cites
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Self-citationPostnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
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Self-citationBuilding the mammalian heart from two sources of myocardial cells
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Conotruncal myocardium arises from a secondary heart field
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The Outflow Tract of the Heart Is Recruited from a Novel Heart-Forming Field
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Cited by
The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development
Gessert, S., & Kühl, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.221531 · Cited by 414
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Self-citationDevelopment of the Pacemaker Tissues of the Heart
Christoffels, V. M., Smits, G. J., Kispert, A., & Moorman, A. F. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.205419 · Cited by 295
The role of secondary heart field in cardiac development
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Isl1 is required for multiple aspects of motor neuron development
Liang, X., Song, M.-R., Xu, Z., Lanuza, G. M., Liu, Y., Zhuang, T., Chen, Y., Pfaff, S. L., Evans, S. M., & Sun, Y. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.04.007 · Cited by 100
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Metadata
- Authors
- Sun, Y., Liang, X., Najafi, N., Cass, M., Lin, L., Cai, C.-L., Chen, J., & Evans, S. M.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 304
- Issue
- 1
- Pages
- 286-296
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2057953361
- Cited by
- 332
- References
- 33
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, Y., Liang, X., Najafi, N., Cass, M., Lin, L., Cai, C.-L., Chen, J., & Evans, S. M. (2007). Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Developmental Biology. https://doi.org/10.1016/j.ydbio.2006.12.048
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