The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Notch signaling regulates regeneration in the avian retina
Open accessAbstract
The chicken retina is capable of limited regeneration. In response to injury, some Müller glia proliferate and de-differentiate into progenitor cells. However, most of these progenitors fail to differentiate into neurons. The Notch pathway is upregulated during retinal regeneration in both fish and amphibians. Since the Notch signaling pathway maintains cells in a progenitor state during development, we hypothesized that a persistently active Notch pathway might prevent a more successful regeneration in the chick retina. We found that Notch signaling components are upregulated in the proliferating progenitors. We also found that blocking the Notch pathway while Müller glia are de-differentiating into progenitor cells prohibits regeneration; conversely, blocking the Notch pathway after the progenitors have been generated from the Müller glia caused a significant increase in the percentage of new neurons. Thus, Notch signaling appears to play two distinct roles during retinal regeneration. Initially, Notch activity is necessary for the de-differentiation/proliferation of Müller glia, while later it inhibits the differentiation of the newly generated progenitor cells.
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“Notch signaling stimulated proliferation of MG-derived progenitors in birds and mammals”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Hayes et al., 2007
Citations
Cites
Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Notch signalling regulates stem cell numbers in vitro and in vivo
Androutsellis‐Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S., Rueger, M. A., Bae, S., Kittappa, R., & McKay, R. D. G. (2006) · Nature · doi:10.1038/nature04940 · Cited by 963
Ellis, P., Fagan, B. M., Magness, S. T., Hutton, S. R., Taranova, O., Hayashi, S., McMahon, A. P., Rao, M. S., & Pevny, L. (2004) · Developmental Neuroscience · doi:10.1159/000082134 · Cited by 756
Müller glia are a potential source of neural regeneration in the postnatal chicken retina
Fischer, A. J., & Reh, T. A. (2001) · Nature Neuroscience · doi:10.1038/85090 · Cited by 579
Self-citationSOX2 is a dose-dependent regulator of retinal neural progenitor competencePreprint
Taranova, O., Magness, S. T., Fagan, B. M., Wu, Y., Surzenko, N., Hutton, S. R., & Pevny, L. H. (2006) · Genes & Development · doi:10.1101/gad.1407906 · Cited by 554
rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.
Furukawa, T., Mukherjee, S., Bao, Z., Morrow, E. M., & Cepko, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81171-x · Cited by 545
Molecular characterization of retinal stem cells and their niches in adult zebrafish
Raymond, P. A., Barthel, L. K., Bernardos, R. L., & Perkowski, J. J. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-36 · Cited by 504
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497 · cited 1×
“Previous studies have shown that DAPTand inhibitory mutations in the Notch pathway have the same effect on development (Geling et al., 2002; Micchelli et al., 2003; Nelson et al., 2006; Nelson et al., 2007).”
BackgroundPotential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454
Henrique, D., Hirsinger, E., Adam, J., Roux, I., Pourquié, O., Ish‐Horowicz, D., & Lewis, J. H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00293-4 · Cited by 431
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Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Müller glial cell reprogramming and retina regeneration
Goldman, D. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3723 · Cited by 652
Stimulation of neural regeneration in the mouse retina
Karl, M. O., Hayes, S., Nelson, B. R., Tan, K., Buckingham, B., & Reh, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807453105 · Cited by 368
Self-citationHB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262
“, 2007) and, at least in the postnatal chick retina, inhibited progenitor differentiation (Hayes et al., 2007).”
BackgroundResultInfluentialAge‐Related Macular Degeneration: New Paradigms for Treatment and Management of AMD
Hernández-Zimbrón, L. F., Zamora-Alvarado, R., la Paz, L. D. O.-D., Vélez-Montoya, R., Zenteno, E., Gulías-Cañizo, R., Quiroz–Mercado, H., & González-Salinas, R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8374647 · Cited by 247
Metadata
- Authors
- Hayes, S., Nelson, B. R., Buckingham, B., & Reh, T. A.
- Affiliations
- University of Washington (US)
- Corresponding author
- Reh, Thomas A.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 312
- Issue
- 1
- Pages
- 300-311
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC2170876
- OpenAlex
- W2152602928
- Cited by
- 141
- References
- 45
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 11 · 2015: 13 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2055 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (EY13475)
- Israel National Road Safety Authority (F32 EY016636)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Notch signaling, retinal regeneration, Müller cells, progenitor cells, dedifferentiation, neuronal differentiation, chicken retina, avian retina, retinal damage
- MeSH terms
- Animals, Cell Count, Cell Differentiation, Chickens, gamma-Aminobutyric Acid, Neuroglia, Neurons, Regeneration, Repressor Proteins, Retina, Stem Cells, Triglycerides, Signal Transduction, Down-Regulation, Up-Regulation, Cell Proliferation, Receptors, Notch
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