Notch signalling: a simple pathway becomes complex

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706 · see citing works

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

van Es, J. H., van Gijn, M. E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D. J., Radtke, F., et al. (2005) · Nature · doi:10.1038/nature03659 · Cited by 1,541 · see citing works

Evidence that stem cells reside in the adult Drosophila midgut epithelium

Micchelli, C. A., & Perrimon, N. (2005) · Nature · doi:10.1038/nature04371 · Cited by 1,139 · see citing works

A Novel Proteolytic Cleavage Involved in Notch Signaling

Brou, C., Logeat, F., Gupta-Rossi, N., Chable-Bessia, C., Bail, O. L., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., & Israël, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80417-7 · Cited by 1,089 · see citing works

The adult Drosophila posterior midgut is maintained by pluripotent stem cells

Ohlstein, B., & Spradling, A. C. (2005) · Nature · doi:10.1038/nature04333 · Cited by 1,089 · see citing works

Notch Signaling: From the Outside In

Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 978 · see citing works

Notch signals control the fate of immature progenitor cells in the intestine

Fré, S., Huyghe, M., Mourikis, P., Robine, S., Louvard, D., & Artavanis‐Tsakonas, S. (2005) · Nature · doi:10.1038/nature03589 · Cited by 936 · see citing works

Notch signalling in vertebrate neural development

Louvi, A., & Artavanis‐Tsakonas, S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1847 · Cited by 887 · see citing works

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A. D., Tian, X., Pan, D., Ray, W. J., & Kopan, R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80416-5 · Cited by 852 · see citing works

Fringe is a glycosyltransferase that modifies Notch

Moloney, D. J., Panin, V. M., Johnston, S. H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K. D., Haltiwanger, R. S., et al. (2000) · Nature · doi:10.1038/35019000 · Cited by 852 · see citing works

γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 824 · see citing works

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Radtke, F., & Raj, K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1186 · Cited by 785 · see citing works

Identification of Drosophila MicroRNA Targets

Stark, A., Brennecke, J., Russell, R. B., & Cohen, S. M. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000060 · Cited by 784 · see citing works

Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

Itoh, M., Kim, C., Palardy, G. R., Oda, T., Jiang, Y., Maust, D. T., Yeo, S., Lorick, K. L., Wright, G. J., Ariza‐McNaughton, L., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00409-4 · Cited by 779 · see citing works

Glycosyltransferase activity of Fringe modulates Notch–Delta interactions

Brückner, K., Perez, L., Clausen, H., & Cohen, S. (2000) · Nature · doi:10.1038/35019075 · Cited by 694 · see citing works

Glycosylation regulates Notch signalling

Haines, N., & Irvine, K. D. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1228 · Cited by 643 · see citing works

N OTCH AND P RESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration

Selkoe, D. J., & Kopan, R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131334 · Cited by 630 · see citing works

Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover

Fryer, C. J., White, B., & Jones, K. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.014 · Cited by 627 · see citing works

MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

Wu, L., Aster, J. C., Blacklow, S. C., Lake, R., Artavanis‐Tsakonas, S., & Griffin, J. D. (2000) · Nature Genetics · doi:10.1038/82644 · Cited by 579 · see citing works

A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint

Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579 · see citing works

Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling

Šestan, N., Artavanis‐Tsakonas, S., & RAKIC, P. T. (1999) · Science · doi:10.1126/science.286.5440.741 · Cited by 571 · see citing works

The Segmentation Clock: Converting Embryonic Time into Spatial Pattern

Pourquié, O. (2003) · Science · doi:10.1126/science.1085887 · Cited by 526 · see citing works

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

Parks, A. L., Klueg, K. M., Stout, J. R., & Muskavitch, M. A. T. (2000) · Development · doi:10.1242/dev.127.7.1373 · Cited by 494 · see citing works

Regulation of Notch Signaling Activity

Schweisguth, F. (2004) · Current Biology · doi:10.1016/j.cub.2004.01.023 · Cited by 467 · see citing works

Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain

McGill, M. A., & McGlade, C. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302827200 · Cited by 455 · see citing works

Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes

Nam, Y., Piotr Sliz, A., Song, L., Aster, J. C., & Blacklow, S. C. (2006) · Cell · doi:10.1016/j.cell.2005.12.037 · Cited by 453 · see citing works

Shedding light on ADAM metalloproteinases

Huovila, A. J., Turner, A. J., Pelto‐Huikko, M., Kärkkäinen, I., & Ortiz, R. M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.006 · Cited by 448 · see citing works

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

Struhl, G., & Adachi, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00061-7 · Cited by 423 · see citing works

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

Qi, H., Rand, M. D., Wu, X., Šestan, N., Wang, W., RAKIC, P. T., Xu, T., & Artavanis‐Tsakonas, S. (1999) · Science · doi:10.1126/science.283.5398.91 · Cited by 415 · see citing works

The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog

Öberg, C., Li, J., Pauley, A. M., Wolf, E., Gurney, M. E., & Lendahl, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103992200 · Cited by 412 · see citing works

Regulation of Notch Signaling by O-Linked Fucose

Okajima, T., & Irvine, K. D. (2002) · Cell · doi:10.1016/s0092-8674(02)01114-5 · Cited by 386 · see citing works

Protein <i>O</i> -fucosyltransferase 1 is an essential component of Notch signaling pathways

Shi, S., & Stanley, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831126100 · Cited by 381 · see citing works

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

Gupta-Rossi, N., Bail, O. L., Gonen, H., Brou, C., Logeat, F., Six, E. M., Ciechanover, A. J., & Israël, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101343200 · Cited by 379 · see citing works

Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA

Wilson, J. J., & Kovall, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.01.035 · Cited by 371 · see citing works

The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

Berdnik, D., Tőrők, T., González‐Gaitán, M., & Knoblich, J. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00215-0 · Cited by 366 · see citing works

The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking

Vaccari, T., & Bilder, D. H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.019 · Cited by 365 · see citing works

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexPreprint

Fryer, C. J., Lamar, E., Türbachova, I., Kintner, C. R., & Jones, K. A. (2002) · Genes & Development · doi:10.1101/gad.991602 · Cited by 359 · see citing works

The roles of receptor and ligand endocytosis in regulating Notch signaling

Borgne, R. L., Bardin, A. J., & Schweisguth, F. (2005) · Development · doi:10.1242/dev.01789 · Cited by 343 · see citing works

Transcriptional Specificity of Human SWI/SNF BRG1 and BRM Chromatin Remodeling Complexes

Kadam, S., & Emerson, B. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00034-0 · Cited by 340 · see citing works

Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta

Lai, E. C., Deblandre, G. A., Kintner, C. R., & Rubin, G. M. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00092-2 · Cited by 339 · see citing works

SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

Wu, G., Lyapina, S., Das, I., Li, J., Gurney, M. E., Pauley, A. M., Chui, I., Deshaies, R. J., & Kitajewski, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7403-7415.2001 · Cited by 338 · see citing works

Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

Qiu, L., Joazeiro, C. A. P., Fang, N., Wang, H., Elly, C., Altman, Y., Fang, D., Hunter, T. R., & Liu, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007300200 · Cited by 332 · see citing works

Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear

Brooker, R. H., Hozumi, K., & Lewis, J. H. (2006) · Development · doi:10.1242/dev.02284 · Cited by 329 · see citing works

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

Matsuno, K., Diederich, R. J., Go, M. J., et al. (1995) · Development · doi:10.1242/dev.121.8.2633 · Cited by 327 · see citing works

Tumor Suppressor Properties of the ESCRT-II Complex Component Vps25 in Drosophila

Thompson, B. J., Mathieu, J., Sung, H.-H., Loeser, E., Rørth, P., & Cohen, S. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.020 · Cited by 322 · see citing works

Immobilization of Notch ligand, Delta-1, is required for induction of Notch signaling

Varnum‐Finney, B., Wu, L., Yu, M., Brashem‐Stein, C., Staats, S. J., Flowers, D. A., Griffin, J. D., & Bernstein, I. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.23.4313 · Cited by 313 · see citing works

Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System

Emery, G., Hutterer, A., Berdnik, D., Mayer, B., Wirtz‐Peitz, F., González‐Gaitán, M., & Knoblich, J. A. (2005) · Cell · doi:10.1016/j.cell.2005.08.017 · Cited by 310 · see citing works

Endocytic control of epithelial polarity and proliferation in Drosophila

Lü, H., & Bilder, D. H. (2005) · Nature Cell Biology · doi:10.1038/ncb1324 · Cited by 307 · see citing works

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

Hsieh, J. J.-D., Zhou, S. S., Chen, L., Young, D. B., & Hayward, S. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.23 · Cited by 305 · see citing works

Mutations in erupted, the Drosophila Ortholog of Mammalian Tumor Susceptibility Gene 101, Elicit Non-Cell-Autonomous Overgrowth

Moberg, K. H., Schelble, S., Burdick, S. K., & Hariharan, I. K. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.018 · Cited by 296 · see citing works

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAsPreprint

Lai, E. C., Tam, B., & Rubin, G. M. (2005) · Genes & Development · doi:10.1101/gad.1291905 · Cited by 295 · see citing works

A model Notch response element detects Suppressor of Hairless–dependent molecular switch

Furriols, M., & Bray, S. J. (2001) · Current Biology · doi:10.1016/s0960-9822(00)00044-0 · Cited by 292 · see citing works

p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro

Wallberg, A. E., Pedersen, K., Lendahl, U., & Roeder, R. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.7812-7819.2002 · Cited by 285 · see citing works

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

Gallagher, E. D., Gao, M., Liu, Y., & Karin, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510664103 · Cited by 277 · see citing works

neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis

Pavlopoulos, E., Pitsouli, C., Klueg, K. M., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00093-4 · Cited by 271 · see citing works

Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells

Lowell, S., Benchoua, A., Heavey, B., & Smith, A. G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040121 · Cited by 260 · see citing works

Regulation of Notch signalling by non-visual β-arrestin

Mukherjee, A., Veraksa, A. N., Bauer, A., Rossé, C., Camonis, J., & Artavanis‐Tsakonas, S. (2005) · Nature Cell Biology · doi:10.1038/ncb1327 · Cited by 253 · see citing works

Instability of Hes7 protein is crucial for the somite segmentation clock

Hirata, H., Bessho, Y., Kokubu, H., Masamizu, Y., Yamada, S., Lewis, J. H., & Kageyama, R. (2004) · Nature Genetics · doi:10.1038/ng1372 · Cited by 253 · see citing works

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch

Wang, W., & Struhl, G. (2004) · Development · doi:10.1242/dev.01413 · Cited by 252 · see citing works

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

Zhou, S. S., Fujimuro, M., Hsieh, J. J.-D., Chen, L., Miyamoto, A., Weinmaster, G., & Hayward, S. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2400-2410.2000 · Cited by 245 · see citing works

Unequal Segregation of Neuralized Biases Notch Activation during Asymmetric Cell Division

Borgne, R. L., & Schweisguth, F. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00187-4 · Cited by 243 · see citing works

Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5

Kurooka, H., & Honjo, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000909200 · Cited by 238 · see citing works

Chaperone Activity of Protein O -Fucosyltransferase 1 Promotes Notch Receptor Folding

Okajima, T., Xu, A., Lei, L., & Irvine, K. D. (2005) · Science · doi:10.1126/science.1108995 · Cited by 237 · see citing works

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

Gupta-Rossi, N., Six, E. M., Bail, O. L., Logeat, F., Chastagner, P., Olry, A., Israël, A., & Brou, C. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310098 · Cited by 223 · see citing works

Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling

Deblandre, G. A., Lai, E. C., & Kintner, C. R. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00091-0 · Cited by 223 · see citing works

Target Selectivity of Vertebrate Notch Proteins

Ong, C., Cheng, H., Chang, L., Ohtsuka, T., Kageyama, R., Stormo, G. D., & Kopan, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506108200 · Cited by 218 · see citing works

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of HairlessPreprint

Barolo, S., Stone, T., Bang, A. G., & Posakony, J. W. (2002) · Genes & Development · doi:10.1101/gad.987402 · Cited by 216 · see citing works

The Lateral Signal for LIN-12/Notch in C. elegans Vulval Development Comprises Redundant Secreted and Transmembrane DSL Proteins

Chen, N., & Greenwald, I. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00021-8 · Cited by 212 · see citing works

Repression by Suppressor of Hairless and activation by Notch are required to define a single row of <i>single-minded</i> expressing cells in the <i>Drosophila</i> embryo

Morel, V., & Schweisguth, F. (2000) · Genes &amp; Development · doi:10.1101/gad.14.3.377 · Cited by 211 · see citing works

Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation

Sakata, T., Sakaguchi, H., Tsuda, L., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.12.028 · Cited by 209 · see citing works

Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1

Yang, L., Nichols, J. T., Yao, C., Manilay, J. O., Robey, E. A., & Weinmaster, G. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0614 · Cited by 206 · see citing works

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing

Ferrés-Marcó, D., Gutierrez, I., Vallejo, D. M., Bolı́var, J., Gutiérrez-Aviñó, F. J., & Domínguez, M. (2006) · Nature · doi:10.1038/nature04376 · Cited by 205 · see citing works

Sec15, a Component of the Exocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Organ Precursors

Jafar‐Nejad, H., Andrews, H. K., Acar, M., Bayat, V., Wirtz‐Peitz, F., Mehta, S., Knoblich, J. A., & Bellen, H. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.06.010 · Cited by 198 · see citing works

Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling

Hori, K., Fostier, M., Ito, M., Fuwa, T. J., Go, M. J., Okano, H., Baron, M., & Matsuno, K. (2004) · Development · doi:10.1242/dev.01448 · Cited by 194 · see citing works

Fringe, Notch, and making developmental boundaries

Irvine, K. D. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80066-5 · Cited by 191 · see citing works

Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells

Overstreet, E., Fitch, E., & Fischer, J. A. (2004) · Development · doi:10.1242/dev.01434 · Cited by 191 · see citing works

Regulation of Notch Endosomal Sorting and Signaling by Drosophila Nedd4 Family Proteins

Wilkin, M. B., Carbery, A.-M., Fostier, M., Aslam, H., Mazaleyrat, S., Higgs, J. E., Myat, A., Evans, D. A. P., Cornell, M. J., & Baron, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.030 · Cited by 190 · see citing works

Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe

Okajima, T., Xu, A., & Irvine, K. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308687200 · Cited by 189 · see citing works

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila

de Joussineau, C., Soule, J. D., Martin, M., Anguille, C., Montcourrier, P., & Alexandre, D. (2003) · Nature · doi:10.1038/nature02157 · Cited by 184 · see citing works

Notch pathway: Making sense of Suppressor of Hairless

Bray, S. J., & Furriols, M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00109-9 · Cited by 184 · see citing works

RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes

Oswald, F., Winkler, M., Cao, Y., Astrahantseff, K., Bourteele, S., Knöchel, W., & Borggrefe, T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10379-10390.2005 · Cited by 183 · see citing works

Mastermind is a putative activator for Notch

Petcherski, A. G., & Kimble, J. E. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00577-7 · Cited by 182 · see citing works

Protein Degradation: Four E3s For The Notch Pathway

Lai, E. C. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00679-0 · Cited by 180 · see citing works

Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila

Borgne, R. L., Remaud, S., Hamel, S., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030096 · Cited by 179 · see citing works

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling inDrosophila

Wang, W., & Struhl, G. (2005) · Development · doi:10.1242/dev.01860 · Cited by 178 · see citing works

An EGFR/Ebi/Sno Pathway Promotes Delta Expression by Inactivating Su(H)/SMRTER Repression during Inductive Notch Signaling

Tsuda, L., Nagaraj, R., Zipursky, S. L., & Banerjee, U. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00875-9 · Cited by 177 · see citing works

Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila

Morel, V., Lecourtois, M., Massiani-Beaudoin, O., Maier, D., Preiss, A., & Schweisguth, F. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00224-x · Cited by 174 · see citing works

The ubiquitin ligaseDrosophilaMind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

Lai, E. C., Roegiers, F., Qin, X., et al. (2005) · Development · doi:10.1242/dev.01825 · Cited by 162 · see citing works

neurotic , a novel maternal neurogenic gene, encodes an O -fucosyltransferase that is essential for Notch-Delta interactions

Sasamura, T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H., Ito, M., Kitagawa, M., Harigaya, K., Spana, E. P., Bilder, D. H., et al. (2003) · Development · doi:10.1242/dev.00679 · Cited by 162 · see citing works

Numb Inhibits Membrane Localization of Sanpodo, a Four-Pass Transmembrane Protein, to Promote Asymmetric Divisions in Drosophila

O’Connor-Giles, K. M., & Skeath, J. B. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00226-0 · Cited by 161 · see citing works

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

Kovall, R. A., & Hendrickson, W. A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600349 · Cited by 155 · see citing works

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

Shaye, D. D., & Greenwald, I. (2002) · Nature · doi:10.1038/nature01234 · Cited by 154 · see citing works

Spatially Restricted Factors Cooperate with Notch in the Regulation of Enhancer of split Genes

Cooper, M. T. D., Tyler, D. M., Furriols, M., Chalkiadaki, A., Delidakis, C., & Bray, S. J. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9691 · Cited by 147 · see citing works

Hrs mediates downregulation of multiple signalling receptors in Drosophila

Jékely, G., & Rørth, P. (2003) · EMBO Reports · doi:10.1038/sj.embor.7400019 · Cited by 144 · see citing works

A Notch-Independent Activity of Suppressor of Hairless Is Required for Normal Mechanoreceptor Physiology

Barolo, S., Walker, R. G., Polyanovsky, A. D., Freschi, G., Keil, T. A., & Posakony, J. W. (2000) · Cell · doi:10.1016/s0092-8674(00)00198-7 · Cited by 144 · see citing works

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila

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Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless

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