Cited by 141Retinal Development and DisordersNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Notch signaling regulates regeneration in the avian retina

Open access

Hayes, Susan, Nelson, Branden R., Buckingham, Brian, Reh, Thomas A.·2007·Developmental Biology

DOI 10.1016/j.ydbio.2007.09.046PMC PMC2170876

Open this paper in CoChat — free account

Abstract

The chicken retina is capable of limited regeneration. In response to injury, some Müller glia proliferate and de-differentiate into progenitor cells. However, most of these progenitors fail to differentiate into neurons. The Notch pathway is upregulated during retinal regeneration in both fish and amphibians. Since the Notch signaling pathway maintains cells in a progenitor state during development, we hypothesized that a persistently active Notch pathway might prevent a more successful regeneration in the chick retina. We found that Notch signaling components are upregulated in the proliferating progenitors. We also found that blocking the Notch pathway while Müller glia are de-differentiating into progenitor cells prohibits regeneration; conversely, blocking the Notch pathway after the progenitors have been generated from the Müller glia caused a significant increase in the percentage of new neurons. Thus, Notch signaling appears to play two distinct roles during retinal regeneration. Initially, Notch activity is necessary for the de-differentiation/proliferation of Müller glia, while later it inhibits the differentiation of the newly generated progenitor cells.

Integrity signals

Registry

Crossref · 10.1016/j.ydbio.2007.09.046

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Notch signalling regulates stem cell numbers in vitro and in vivo
Androutsellis‐Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S., Rueger, M. A., Bae, S., Kittappa, R., & McKay, R. D. G. (2006) · Nature · doi:10.1038/nature04940 · Cited by 963
SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult
Ellis, P., Fagan, B. M., Magness, S. T., Hutton, S. R., Taranova, O., Hayashi, S., McMahon, A. P., Rao, M. S., & Pevny, L. (2004) · Developmental Neuroscience · doi:10.1159/000082134 · Cited by 756
Müller glia are a potential source of neural regeneration in the postnatal chicken retina
Fischer, A. J., & Reh, T. A. (2001) · Nature Neuroscience · doi:10.1038/85090 · Cited by 579
Self-citation
SOX2 is a dose-dependent regulator of retinal neural progenitor competencePreprint
Taranova, O., Magness, S. T., Fagan, B. M., Wu, Y., Surzenko, N., Hutton, S. R., & Pevny, L. H. (2006) · Genes & Development · doi:10.1101/gad.1407906 · Cited by 554
rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.
Furukawa, T., Mukherjee, S., Bao, Z., Morrow, E. M., & Cepko, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81171-x · Cited by 545
Molecular characterization of retinal stem cells and their niches in adult zebrafish
Raymond, P. A., Barthel, L. K., Bernardos, R. L., & Perkowski, J. J. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-36 · Cited by 504
A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497 · cited 1×
“Previous studies have shown that DAPTand inhibitory mutations in the Notch pathway have the same effect on development (Geling et al., 2002; Micchelli et al., 2003; Nelson et al., 2006; Nelson et al., 2007).”
Background
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454
Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina
Henrique, D., Hirsinger, E., Adam, J., Roux, I., Pourquié, O., Ish‐Horowicz, D., & Lewis, J. H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00293-4 · Cited by 431

Show all 45 references

Sorted by citations

Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Müller glial cell reprogramming and retina regeneration
Goldman, D. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3723 · Cited by 652
Stimulation of neural regeneration in the mouse retina
Karl, M. O., Hayes, S., Nelson, B. R., Tan, K., Buckingham, B., & Reh, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807453105 · Cited by 368
Self-citation
HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262
“, 2007) and, at least in the postnatal chick retina, inhibited progenitor differentiation (Hayes et al., 2007).”
BackgroundResultInfluential
Age‐Related Macular Degeneration: New Paradigms for Treatment and Management of AMD
Hernández-Zimbrón, L. F., Zamora-Alvarado, R., la Paz, L. D. O.-D., Vélez-Montoya, R., Zenteno, E., Gulías-Cañizo, R., Quiroz–Mercado, H., & González-Salinas, R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8374647 · Cited by 247
Regenerative medicine for retinal diseases: activating endogenous repair mechanisms
Karl, M., & Reh, T. A. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.02.003 · Cited by 204
Self-citation
A comparative view of regenerative neurogenesis in vertebrates
Alunni, A., & Bally‐Cuif, L. (2016) · Development · doi:10.1242/dev.122796 · Cited by 189
Neural Regeneration and Cell Replacement: A View from the Eye
Lamba, D. A., Karl, M., & Reh, T. A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.05.002 · Cited by 173
Self-citation
Reprogramming Müller Glia to Regenerate Retinal Neurons
Lahne, M., Nagashima, M., Hyde, D. R., & Hitchcock, P. F. (2020) · Annual Review of Vision Science · doi:10.1146/annurev-vision-121219-081808 · Cited by 160
Repressing Notch Signaling and Expressing TNFα Are Sufficient to Mimic Retinal Regeneration by Inducing Müller Glial Proliferation to Generate Committed Progenitor Cells
Conner, C., Ackerman, K. M., Lahne, M., Hobgood, J. S., & Hyde, D. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0498-14.2014 · Cited by 149
Müller glial cell‐dependent regeneration of the neural retina: An overview across vertebrate model systems
Hamon, A., Roger, J. E., Yang, X.-J., & Perron, M. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24375 · Cited by 139
Cellular strategies for retinal repair by photoreceptor replacement
Jayakody, S. A., Gonzalez-Cordero, A., Ali, R. R., & Pearson, R. A. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.01.003 · Cited by 133
The inhibitor of phagocytosis, O-phospho-l-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina
Bailey, T. J., Fossum, S. L., Fimbel, S. M., Montgomery, J. E., & Hyde, D. R. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.07.017 · Cited by 117
Turning Müller Glia into Neural Progenitors in the Retina
Fischer, A. J., & Bongini, R. E. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8152-2 · Cited by 113
Notch signaling influences neuroprotective and proliferative properties of mature Müller glia
Ghai, K., Zelinka, C., & Fischer, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4919-09.2010 · Cited by 111
Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity
Fischer, A. J., Scott, M. A., Ritchey, E. R., & Sherwood, P. (2009) · Glia · doi:10.1002/glia.20868 · Cited by 111
Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina
Fischer, A. J., Scott, M. A., & Tuten, W. (2009) · Glia · doi:10.1002/glia.20743 · Cited by 105
Reactive microglia and macrophage facilitate the formation of Müller glia‐derived retinal progenitors
Fischer, A. J., Zelinka, C. P., Gallina, D., Scott, M. A., & Todd, L. J. (2014) · Glia · doi:10.1002/glia.22703 · Cited by 100
Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling
de Melo, J., Zibetti, C., Clark, B. S., Hwang, W., Miranda‐Angulo, A. L., Qian, J. X., & Blackshaw, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3145-15.2016 · Cited by 100
Regulated Reprogramming in the Regeneration of Sensory Receptor Cells
Bermingham‐McDonogh, O., & Reh, T. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.015 · Cited by 98
Self-citation
Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
Nelson, B. R., Hartman, B. H., Ray, C. A., Hayashi, T., Bermingham‐McDonogh, O., & Reh, T. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21848 · Cited by 94
Self-citation
The chick eye in vision research: An excellent model for the study of ocular disease
Wisely, C. E., Sayed, J. A., Tamez, H. M., Zelinka, C. P., Abdel‐Rahman, M. H., Fischer, A. J., & Cebulla, C. M. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.004 · Cited by 97
Lens and retina regeneration: new perspectives from model organisms
Barbosa-Sabanero, K., Hoffmann, A., Judge, C. J., Lightcap, N., Tsonis, P. A., & Rio‐Tsonis, K. D. (2012) · Biochemical Journal · doi:10.1042/bj20120813 · Cited by 92
Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration
Grotek, B., Wehner, D., & Weidinger, G. (2013) · Development · doi:10.1242/dev.087452 · Cited by 93
Wnt Signaling Promotes Müller Cell Proliferation and Survival after Injury
Liu, B., Hunter, D. J., Rooker, S. M., Chan, A. Y., Paulus, Y. M., Leucht, P., Nusse, Y. M., Nomoto, H., & Helms, J. A. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10774 · Cited by 92
Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina
Todd, L. J., Squires, N. A., Suarez, L., & Fischer, A. J. (2016) · Scientific Reports · doi:10.1038/srep35703 · Cited by 87
A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina
Gallina, D., Todd, L. J., & Fischer, A. J. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.019 · Cited by 88
Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration
Dishowitz, M. I., Terkhorn, S. P., Bostic, S. A., & Hankenson, K. D. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21518 · Cited by 83
Müller Glia-Mediated Retinal Regeneration
Gao, H., Luodan, A., Huang, X., Chen, X., & Xu, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02274-w · Cited by 84
Strategies for retinal repair: cell replacement and regeneration
Lamba, D. A., Karl, M., & Reh, T. A. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17502-7 · Cited by 81
Self-citation
Lactobacillus reuteri Stimulates Intestinal Epithelial Proliferation and Induces Differentiation into Goblet Cells in Young Chickens
Xie, S., Zhao, S., Jiang, L., Lu, L., Yang, Q., & Yu, Q. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b06256 · Cited by 81
Glucocorticoid receptors in the retina, Müller glia and the formation of Müller glia-derived progenitors
Gallina, D., Zelinka, C. P., & Fischer, A. J. (2014) · Development · doi:10.1242/dev.109835 · Cited by 77
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
Heng, J. S., Rattner, A., Stein-O’Brien, G., Winer, B. L., Jones, B. W., Vernon, H. J., Goff, L. A., & Nathans, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821122116 · Cited by 74
Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals
Stanke, J. J., Moose, H. E., El‐Hodiri, H. M., & Fischer, A. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22335 · Cited by 74
RNA-Seq Reveals Dynamic Changes of Gene Expression in Key Stages of Intestine Regeneration in the Sea Cucumber Apostichopus japonicas
Sun, L., Yang, H., Chen, M., Ma, D., & Lin, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069441 · Cited by 71
Controlling Destiny through Chemistry: Small-Molecule Regulators of Cell Fate
Firestone, A. J., & Chen, J. (2009) · ACS Chemical Biology · doi:10.1021/cb900249y · Cited by 71
Hes5 Expression in the Postnatal and Adult Mouse Inner Ear and the Drug-Damaged Cochlea
Hartman, B. H., Başak, O., Nelson, B. R., Taylor, V., Bermingham‐McDonogh, O., & Reh, T. A. (2009) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-009-0162-2 · Cited by 66
Self-citation
mTor-signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina
Zelinka, C. P., Volkov, L. I., Goodman, Z. A., Todd, L. J., Palazzo, I., Bishop, W. A., & Fischer, A. J. (2016) · Development · doi:10.1242/dev.133215 · Cited by 62
A novel type of glial cell in the retina is stimulated by insulin‐like growth factor 1 and may exacerbate damage to neurons and Müller glia
Fischer, A. J., Scott, M. A., Zelinka, C. P., & Sherwood, P. (2009) · Glia · doi:10.1002/glia.20950 · Cited by 62
Retinal regeneration in birds and mice
Wilken, M. S., & Reh, T. A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.028 · Cited by 60
Self-citation
NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina
Palazzo, I., Deistler, K., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2020) · Development · doi:10.1242/dev.183418 · Cited by 60
Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells
Das, D., Lanner, F., Main, H., Andersson, E. R., Bergmann, O., Sahlgren, C., Heldring, N., Hermanson, O., Hansson, E. M., & Lendahl, U. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.09.018 · Cited by 61
Hedgehog-signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the retina
Todd, L. J., & Fischer, A. J. (2015) · Development · doi:10.1242/dev.121616 · Cited by 57
What determines neurogenic competence in glia?
Costa, M. R., Götz, M., & Berninger, B. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.002 · Cited by 62
BMP‐ and TGFβ‐signaling regulate the formation of Müller glia‐derived progenitor cells in the avian retina
Todd, L. J., Palazzo, I., Squires, N. A., Mendonca, N., & Fischer, A. J. (2017) · Glia · doi:10.1002/glia.23185 · Cited by 56
The Regulation of Notch Signaling in Retinal Development and Regeneration
Mills, E. A., & Goldman, D. J. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0153-7 · Cited by 57
Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia‐derived progenitor cells in chick and mouse retinas
Campbell, W. A., Fritsch‐Kelleher, A., Palazzo, I., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2021) · Glia · doi:10.1002/glia.23976 · Cited by 51
Müller Glia: A Promising Target for Therapeutic Regeneration
Ahmad, I., Debbio, C. B. D., Das, A. V., & Parameswaran, S. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7308 · Cited by 57
Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina
Todd, L. J., Suarez, L., Quinn, C. H., & Fischer, A. J. (2017) · Stem Cells · doi:10.1002/stem.2742 · Cited by 53
Heparin-binding EGF-like growth factor (HB-EGF) stimulates the proliferation of Müller glia-derived progenitor cells in avian and murine retinas
Todd, L. J., Volkov, L. I., Zelinka, C. P., Squires, N. A., & Fischer, A. J. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.10.004 · Cited by 52
The Reactivity, Distribution and Abundance of Non-Astrocytic Inner Retinal Glial (NIRG) Cells Are Regulated by Microglia, Acute Damage, and IGF1
Zelinka, C. P., Scott, M. A., Volkov, L. I., & Fischer, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044477 · Cited by 50
Retinal regeneration requires dynamic Notch signaling
Hyde, D. R., Campbell, L. J., Levendusky, J., & Steines, S. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327326 · Cited by 49
Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular ReprogrammingPreprint
Todd, L. J., & Reh, T. A. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040816 · Cited by 53
Self-citation
W nt/β‐catenin‐signaling and the formation of M üller glia‐derived progenitors in the chick retina
Gallina, D., Palazzo, I., Steffenson, L. N., Todd, L. J., & Fischer, A. J. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22370 · Cited by 43
Ciliary Neurotrophic Factor-Mediated Signaling Regulates Neuronal Versus Glial Differentiation of Retinal Stem Cells/Progenitors by Concentration-Dependent Recruitment of Mitogen-Activated Protein Kinase and Janus Kinase-Signal Transducer and Activator of Transcription Pathways in Conjunction with Notch Signaling
Bhattacharya, S., Das, A. V., Mallya, K. B., & Ahmad, I. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0222 · Cited by 47
Activation of glucocorticoid receptors in Müller glia is protective to retinal neurons and suppresses microglial reactivity
Gallina, D., Zelinka, C. P., Cebulla, C. M., & Fischer, A. J. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.007 · Cited by 41
Baf60c is a component of the neural progenitor‐specific BAF complex in developing retina
Lamba, D. A., Hayes, S., Karl, M., & Reh, T. A. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21697 · Cited by 43
Self-citation
Neurotransmitter-Regulated Regeneration in the Zebrafish Retina
Rao, M. B., Didiano, D., & Patton, J. G. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.02.007 · Cited by 40
Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina.
Lelièvre, E., Lek, M., Boije, H., Houille-vernes, L., Brajeul, V., Slembrouck, A., Roger, J., Sahel, J., Matter, J., Sennlaub, F., et al. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.07.033 · Cited by 38
Nuclear Factor I in neurons, glia and during the formation of Müller glia‐derived progenitor cells in avian, porcine and primate retinas
El‐Hodiri, H. M., Campbell, W. A., Kelly, L. E., Hawthorn, E. C., Schwartz, M., Jalligampala, A., McCall, M. A., Meyer, K., & Fischer, A. J. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25270 · Cited by 31
Mobilizing endogenous stem cells for retinal repair
Yu, H., Vu, T. H. K., Cho, K., Guo, C., & Chen, D. F. (2013) · Translational research · doi:10.1016/j.trsl.2013.11.011 · Cited by 31
Understanding regeneration through proteomics
Franco, C., Soares, R. F., Pires, E., Kočí, K., de Almeida, A. M., Santos, R., & Coelho, A. V. (2012) · PROTEOMICS · doi:10.1002/pmic.201200397 · Cited by 31
Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina
Campbell, W. A., Tangeman, A., El‐Hodiri, H. M., Hawthorn, E. C., Hathoot, M., Blum, S., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2022) · Development · doi:10.1242/dev.200127 · Cited by 28
Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1
Debbio, C. B. D., Mir, Q. A., Parameswaran, S., Mathews, S., Xia, X., Zheng, L. H., Neville, A. J., & Ahmad, I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152025 · Cited by 28
Rebuilding the Retina: Prospects for Müller Glial-mediated Self-repair
Langhe, R., & Pearson, R. A. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1669665 · Cited by 26
Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids
Chew, S., Martinez, C., Chirco, K. R., Kandoi, S., & Lamba, D. A. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.10.12 · Cited by 22
Heparin-binding epidermal growth factor and fibroblast growth factor 2 rescue Müller glia-derived progenitor cell formation in microglia- and macrophage-ablated chick retinas
El‐Hodiri, H. M., Bentley, J. R., Reske, A., Taylor, O. B., Palazzo, I., Campbell, W. A., Halloy, N. R., & Fischer, A. J. (2023) · Development · doi:10.1242/dev.202070 · Cited by 23
Making neurons from mature glia: A far-fetched dream?
Berninger, B. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.004 · Cited by 22
Correction: RNA-Seq Reveals Dynamic Changes of Gene Expression in Key Stages of Intestine Regeneration in the Sea Cucumber Apostichopus japonicas
Sun, L., Yang, H., Chen, M., Ma, D., & Lin, C. (2013) · PLoS ONE · doi:10.1371/annotation/d2d71c46-4254-46bd-8a83-9a7a56f2abdf · Cited by 22
De novo neurogenesis by targeted expression of Atoh7 to Müller glia cells
Lust, K., Sinn, R., Saturnino, A. P., Centanin, L., & Wittbrodt, J. (2016) · Development · doi:10.1242/dev.135905 · Cited by 21
Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration
Liu, Y., Wang, C., & Su, G. (2019) · Journal of Ophthalmology · doi:10.1155/2019/5743109 · Cited by 24
Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling
Fleming, T., Balderas-Márquez, J. E., Epardo, D., Ávila-Mendoza, J., Carranza, M., Luna, M., Harvey, S., Arámburo, C., & Martínez-Moreno, C. G. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27473 · Cited by 21
Notch signaling pathway regulates proliferation and differentiation of immortalized Müller cells under hypoxic conditions in vitro
Wang, Z., Sugano, E., Isago, H., Murayama, N., Tamai, M., & Tomita, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.025 · Cited by 20
Regenerative Effect of Growth Hormone (GH) in the Retina after Kainic Acid Excitotoxic Damage
Martínez-Moreno, C. G., Epardo, D., Balderas-Márquez, J. E., Fleming, T., Carranza, M., Luna, M., Harvey, S., & Arámburo, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184433 · Cited by 20
Chromatin access regulates the formation of Müller glia‐derived progenitor cells in the retina
Campbell, W. A., El‐Hodiri, H. M., Torres, D., Hawthorn, E. C., Kelly, L. E., Volkov, L. I., Akanonu, D., & Fischer, A. J. (2023) · Glia · doi:10.1002/glia.24366 · Cited by 19
Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states
Chen, X., & Emerson, M. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-93692-w · Cited by 17
Retinal Glia
Reichenbach, A., & Bringmann, A. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00122ed1v01y201412ngl003 · Cited by 18
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer
Lee, E. J., Kim, M., Park, S., Shim, J. H., Cho, H., Park, J.-A., Park, K., Lee, D., Kim, J., Jeong, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58290-8 · Cited by 16
Emerging pharmacological approaches to promote neurogenesis from endogenous glial cells
Boda, E., Nato, G., & Buffo, A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.129 · Cited by 16
Retina regeneration: lessons from vertebrates
Sharma, P., & Ramachandran, R. (2022) · Oxford Open Neuroscience · doi:10.1093/oons/kvac012 · Cited by 16
Genetic and epigenetic regulators of retinal Müller glial cell reprogramming
Xiao, X., Liao, Z., & Zou, J. (2023) · Advances in Ophthalmology Practice and Research · doi:10.1016/j.aopr.2023.05.004 · Cited by 14
Regulating the formation of Müller glia‐derived progenitor cells in the retina
Taylor, O. B., El‐Hodiri, H. M., Palazzo, I., Todd, L. J., & Fischer, A. J. (2024) · Glia · doi:10.1002/glia.24635 · Cited by 14
The capacity of neural crest‐derived stem cells for ocular repair
Liu, B., Hunter, D. J., Smith, A. A., Chen, S., & Helms, J. A. (2014) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21077 · Cited by 18
Molecular Factors of the Maintenance and Activation of the Juvenile Phenotype of Cellular Sources for Eye Tissue Regeneration
Grigoryan, E. N. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918110032 · Cited by 14
The Chick as a Model for Retina Development and Regeneration
Belecky‐Adams, T. L., Haynes, T., Wilson, J. M., & Rio‐Tsonis, K. D. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374169-1.00008-4 · Cited by 13
An insight on established retinal injury mechanisms and prevalent retinal stem cell activation pathways in vertebrate models
Sherpa, R. D., & Hui, S. P. (2021) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12177 · Cited by 12
Biomaterial Design Inspired by Regenerative Research Organisms
Sapru, S., Dill, M. N., & Simmons, C. S. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00486 · Cited by 11
Mustard gas exposure instigates retinal Müller cell gliosis
Mahaling, B., Sinha, N. R., Sokupa, S., Addi, U. R., Mohan, R. R., & Chaurasia, S. S. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109461 · Cited by 12
ID factors regulate the ability of Müller glia to become proliferating neurogenic progenitor‐like cells
Taylor, O. B., Patel, S. P., Hawthorn, E. C., El‐Hodiri, H. M., & Fischer, A. J. (2024) · Glia · doi:10.1002/glia.24523 · Cited by 10
Retinal Genomic Fabric Remodeling after Optic Nerve Injury
Victorino, P. H., Marra, C., Iacobaş, D. A., Iacobaş, S., Spray, D. C., Linden, R., Adesse, D., & Petrs‐Silva, H. (2021) · Genes · doi:10.3390/genes12030403 · Cited by 12
Potential Endogenous Cell Sources for Retinal Regeneration in Vertebrates and Humans: Progenitor Traits and Specialization
Grigoryan, E. N. (2020) · Biomedicines · doi:10.3390/biomedicines8070208 · Cited by 12
Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality
Subramani, M., Murugeswari, P., Dhamodaran, K., Chevour, P., Gunasekaran, S., Kumar, R. S., Jayadev, C., Shetty, R., Begum, N., & Das, D. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18330 · Cited by 10
Selective neuronal lineages derived from Dll4‐expressing progenitors/precursors in the retina and spinal cord
Zou, M., Luo, H., & Xiang, M. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24185 · Cited by 10
Involvement of HB-EGF/Ascl1/Lin28a Genes in Dedifferentiation of Adult Mammalian Müller Glia
Stanchfield, M. L., Webster, S. E., Webster, M. K., & Linn, C. L. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00200 · Cited by 9
Neurogenesis in the Damaged Mammalian Brain
Nakafuku, M., & Grande, A. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00074-5 · Cited by 8
Temporal and spatial expression of CCN3 during retina development
Laurent, M., Dréau, G. L., Guillonneau, X., Lelièvre, E. C., Slembrouck-Brec, A., Goureau, O., Martinerie, C., & Marx, M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20994 · Cited by 7
Müller Glia, Vision-Guided Ocular Growth, Retinal Stem Cells, and a Little Serendipity
Fischer, A. J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8330 · Cited by 7
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cellsPreprint
Taylor, O. B., DeGroff, N., El‐Hodiri, H. M., Gao, C., & Fischer, A. J. (2024) · eLife · doi:10.7554/elife.102151.4 · Cited by 8
On the value of diverse organisms in auditory research: From fish to flies to humans
Brown, A. D., Hayward, T., Portfors, C. V., & Coffin, A. B. (2023) · Hearing Research · doi:10.1016/j.heares.2023.108754 · Cited by 6
The Regenerative Potential of the Vertebrate Retina: Lessons from the Zebrafish
Jeremy, N., Currie, P. D., & Jusuf, P. R. (2014) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-4939-0787-8_3 · Cited by 7

Authors: Hayes, S., Nelson, B. R., Buckingham, B., & Reh, T. A.
Affiliations: University of Washington (US)
Corresponding author: Reh, Thomas A.
ORCID: Nelson, Branden R.
Reh, Thomas A.
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2007-12
Volume: 312
Issue: 1
Pages: 300-311
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2007.09.046
PMC: PMC2170876
OpenAlex: W2152602928
Cited by: 141
References: 45
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 11 · 2015: 13 · 2014: 7 · 2013: 8 · 2012: 9
FWCI: 3.31
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2055 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (EY13475)
Israel National Road Safety Authority (F32 EY016636)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Notch signaling, retinal regeneration, Müller cells, progenitor cells, dedifferentiation, neuronal differentiation, chicken retina, avian retina, retinal damage
MeSH terms: Animals, Cell Count, Cell Differentiation, Chickens, gamma-Aminobutyric Acid, Neuroglia, Neurons, Regeneration, Repressor Proteins, Retina, Stem Cells, Triglycerides, Signal Transduction, Down-Regulation, Up-Regulation, Cell Proliferation, Receptors, Notch

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Notch signaling regulates regeneration in the avian retina

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks