Cited by 51Developmental Biology and Gene RegulationNeurobiology and Insect Physiology ResearchRetinal Development and Disorders

Probing the Drosophila retinal determination gene network in Tribolium (I): The early retinal genes dachshund, eyes absent and sine oculis

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Yang, Xiaoyun, ZarinKamar, Nazanin, Bao, Riyue, Friedrich, Markus·2009·Developmental Biology

Abstract

The early retinal genes dachshund (dac), eyes absent (eya) and sine oculis (so) are key regulators of adult eye development in Drosophila. Expression data implicate homologs of all three transcription factor genes in vertebrate eye development. However, functional confirmation has thus far only been reported for so homologs. We therefore investigated expression and function of these genes in the red flour beetle Tribolium castaneum. Our results show that Tribolium so and eya are essential for both larval and adult eye development. Moreover, widespread co-expression and indistinguishable knockdown phenotypes suggests eya interaction with so in many tissues. dac expression, by contrast, overlaps with eya and so only in select tissues, which, however, includes the primordia of larval and adult eyes. Notwithstanding, dac knockdown has no detectable effect on larval eye development and causes strong but incomplete adult eye reduction. In a parallel study, we show that dac is essential for adult eye development in combination with the Pax6 transcription factors eyeless (ey) and twin of eyeless (toy). Taken together, our data reveal conservation but also evolutionary plasticity of the Drosophila retinal determination gene network in insects.

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Crossref · 10.1016/j.ydbio.2009.02.040

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Authors
Yang, X., ZarinKamar, N., Bao, R., & Friedrich, M.
Affiliations
Wayne State University (US)
Corresponding author
Friedrich, Markus
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2009-09
Volume
333
Issue
1
Pages
202-214
ISSN
0012-1606 (ISSN-L)
OpenAlex
W2044139554
Cited by
51
References
91
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2020: 5 · 2019: 1 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
1.88
Type
journal article
Language
en
Open access
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Keywords
Tribolium castaneum, Dachshund, eyes absent, sine oculis, eye development, Pax6, eyeless, transcription factors, gene co-expression, evolutionary conservation, evolutionary plasticity
MeSH terms
Amino Acid Sequence, Animals, Drosophila, Eye Proteins, Larva, Molecular Sequence Data, Nuclear Proteins, Tribolium, Conserved Sequence, Homeodomain Proteins, Insect Proteins, Drosophila Proteins, Gene Regulatory Networks, Compound Eye, Arthropod, Gene Knockdown Techniques

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