Molecular mechanisms of de novo lumen formation
Abstract
Many organs contain networks of epithelial tubes that transport gases or fluids. A lumen can be generated by tissue that enwraps a pre-existing extracellular space or it can arise de novo either between cells or within a single cell in a position where there was no space previously. Apparently distinct mechanisms of de novo lumen formation observed in vitro - in three-dimensional cultures of endothelial and Madin-Darby canine kidney (MDCK) cells - and in vivo - in zebrafish vasculature, Caenorhabditis elegans excretory cells and the Drosophila melanogaster trachea - in fact share many common features. In all systems, lumen formation involves the structured expansion of the apical plasma membrane through general mechanisms of vesicle transport and of microtubule and actin cytoskeleton regulation.
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The hollowing form was usually seen in the early stage of formation of the lumen of blood vessels and the formation of the intestinal lumen of zebrafish, and these developmental processes were generally not accompanied by cell death.
“The hollowing form was usually seen in the early stage of formation of the lumen of blood vessels and the formation of the intestinal lumen of zebrafish, and these developmental processes were generally not accompanied by cell death.[26,27]”
From Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids (2022) · cites this paper as [27]
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Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails
Legate, K. R., & Fässler, R. (2009) · Journal of Cell Science · doi:10.1242/jcs.041624 · Cited by 370 · see citing works
Macara, I. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1332 · Cited by 341 · see citing works
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids
Du, L., Zhang, L., Zhao, J., Chen, Z., Liu, X., Cao, M., You, L., Zhang, Y., Fu, X., & Li, H. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001936 · Cited by 6 · see citing works
- Authors
- Sigurbjörnsdóttir, S., Mathew, R., & Leptin, M.
- Affiliations
- European Molecular Biology Laboratory (DE)
- University of Cologne (DE)
- Corresponding author
- Leptin, Maria
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-09-04
- Volume
- 15
- Issue
- 10
- Pages
- 665-676
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1970163774
- Cited by
- 177
- References
- 2
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 10 · 2023: 16 · 2022: 26 · 2021: 16 · 2020: 13 · 2019: 16 · 2018: 16 · 2017: 13 · 2016: 16 · 2015: 10 · 2014: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- vesicle trafficking, microtubule cytoskeleton, actin cytoskeleton, MDCK cells, Drosophila trachea, 3D cell culture
- MeSH terms
- Animals, Cell Line, Cell Membrane, Dogs, Drosophila melanogaster, Epithelium, Extracellular Space, Humans, Actin Cytoskeleton, Microtubules, Trachea, Umbilical Veins, Zebrafish, Caenorhabditis elegans, Madin Darby Canine Kidney Cells
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