CoChat
Sign Up
Cited by 174Skin and Cellular Biology ResearchCellular Mechanics and InteractionsNuclear Structure and Function

Intermediate filaments and stress

Pekny, Milos, Lane, E. Birgitte·2007·Experimental Cell Research
DOI 10.1016/j.yexcr.2007.04.023
Open this paper in CoChat — free account

Abstract

Before we can explain why so many closely related intermediate filament genes have evolved in vertebrates, while maintaining such dramatically tissue specific expression, we need to understand their function. The best evidence for intermediate filament function comes from observing the consequences of mutation and mis-expression, primarily in human tissues. Mostly these observations suggest that intermediate filaments are important in allowing individual cells, the tissues and whole organs to cope with various types of stress, in health and disease. Exactly how they do this is unclear and many aspects of cell dysfunction have been associated with intermediate filaments to date. In particular, it is still not clear whether the non-mechanical functions now being attributed to intermediate filaments are primary functions of these structural proteins, or secondary consequences of their function to respond to mechanical stress. We discuss selected situations in which responses to stress are clearly influenced by intermediate filaments.

Integrity signals

Registry

Crossref · 10.1016/j.yexcr.2007.04.023

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Absence of GFAP and/or Vim in mice has no major effect under physiological conditions.

    “Absence of GFAP and/or Vim in mice has no major effect under physiological conditions (17–20), reflecting the role of intermediate filament (nanofilament) system as a signaling platform in situations connected with cellular stress (21).”

    From Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice (2013) · cites this paper as [21]

  • Astrocytes support neuronal function by regulating extracellular concentrations of ions and neurotransmitters, especially in response to cellular stress.

    “Astrocytes support neuronal function by regulating extracellular concentrations of ions and neurotransmitters (65), especially in response to cellular stress (21).”

    From Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice (2013) · cites this paper as [21]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Pekny, M., & Lane, E. B.
Affiliations
  • University of Gothenburg (SE)
  • University of Dundee (GB)
Corresponding author
  • Pekny, Milos
  • Lane, E. Birgitte
ORCID
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2007-06
Volume
313
Issue
10
Pages
2244-2254
ISSN
0014-4827 (ISSN-L)
DOI
10.1016/j.yexcr.2007.04.023
OpenAlex
W2054467590
Cited by
174
References
2
Citations by year
2025: 4 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 15 · 2018: 6 · 2017: 9 · 2016: 11 · 2015: 16 · 2014: 14 · 2013: 9 · 2012: 9
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Experimental Cell Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Biomedical Research Council
  • Cancer Research UK (C26/A1461)
  • Västra Götalandsregionen
  • Carl Tryggers Stiftelse för Vetenskaplig Forskning
  • Torsten Söderbergs Stiftelse
  • Hjärnfonden
  • Dystrophic Epidermolysis Bullosa Research Association
  • Vetenskapsrådet (11548)
  • STROKE-Riksförbundet
  • Axel Linders Stiftelse
  • Rune och Ulla Amlövs Stiftelse för Neurologisk och Reumatologisk Forskning
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
intermediate filaments, mechanical stress, stress response, tissue-specific gene expression, gene evolution, structural proteins
MeSH terms
Adaptation, Physiological, Animals, Desmin, Humans, Intermediate Filament Proteins, Intermediate Filaments, Keratins, Mutation, Stress, Physiological, Stress, Mechanical, Vimentin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review