Glial cells in (patho)physiology
Open accessAbstract
Neuroglial cells define brain homeostasis and mount defense against pathological insults. Astroglia regulate neurogenesis and development of brain circuits. In the adult brain, astrocytes enter into intimate dynamic relationship with neurons, especially at synaptic sites where they functionally form the tripartite synapse. At these sites, astrocytes regulate ion and neurotransmitter homeostasis, metabolically support neurons and monitor synaptic activity; one of the readouts of the latter manifests in astrocytic intracellular Ca(2+) signals. This form of astrocytic excitability can lead to release of chemical transmitters via Ca(2+) -dependent exocytosis. Once in the extracellular space, gliotransmitters can modulate synaptic plasticity and cause changes in behavior. Besides these physiological tasks, astrocytes are fundamental for progression and outcome of neurological diseases. In Alzheimer's disease, for example, astrocytes may contribute to the etiology of this disorder. Highly lethal glial-derived tumors use signaling trickery to coerce normal brain cells to assist tumor invasiveness. This review not only sheds new light on the brain operation in health and disease, but also points to many unknowns.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This inflammation not only occurs in response to Aβ deposition, but is also capable of generating, via feedback mechanisms, more Aβ while weakening the mechanisms responsible for its elimination.
“This inflammation not only occurs in response to Aβ deposition, but is also capable of generating, via feedback mechanisms, more Aβ while weakening the mechanisms responsible for its elimination (Parpura et al., 2012).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Parpura et al., 2012
In later stages of AD, there is destruction of axons, dendrites, and synapses, in which microglia has a relevant role.
“It has been reported that in the later stages of AD, there is destruction of axons, dendrites, and synapses, in which microglia has a relevant role (Parpura et al., 2012).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Parpura et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,718 · see citing works
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works
Glycine potentiates the NMDA response in cultured mouse brain neurons
Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,151 · see citing works
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · see citing works
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529 · see citing works
Self-citationDecreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078 · see citing works
Glutamate-mediated astrocyte–neuron signalling
Parpura, V., Basarsky, T. A., Liu, F., Jeftinija, K., Jeftinija, S., & Haydon, P. G. (1994) · Nature · doi:10.1038/369744a0 · Cited by 1,737 · see citing works
Self-citationSynaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works
Astrocyte activation and reactive gliosis
Pekny, M., & Nilsson, M. (2005) · Glia · doi:10.1002/glia.20207 · Cited by 1,611 · see citing works
Self-citationWnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,510 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Astroglia induce neurogenesis from adult neural stem cells
Song, H., Stevens, C. F., & Gage, F. H. (2002) · Nature · doi:10.1038/417039a · Cited by 1,452 · see citing works
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389 · see citing works
Self-citationThe Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease
Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Astrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280 · see citing works
Self-citationD-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Mothet, J., Parent, A., Wolosker, H., Brady, R., Linden, D. J., Ferris, C., Rogawski, M., & Snyder, S. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.9.4926 · Cited by 1,164 · see citing works
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998) · Nature · doi:10.1038/34651 · Cited by 1,143 · see citing works
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects
Davison, A. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.8.1021-a · Cited by 949 · see citing works
Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934 · see citing works
Self-citationThree-Dimensional Relationships between Hippocampal Synapses and Astrocytes
Ventura, R., & Harris, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06897.1999 · Cited by 900 · see citing works
Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.025 · Cited by 893 · see citing works
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 861 · see citing works
Purinergic signalling in neuron–glia interactions
Fields, R. D., & Burnstock, G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1928 · Cited by 852 · see citing works
Glutamate exocytosis from astrocytes controls synaptic strength
Jourdain, P., Bergersen, L. H., Bhaukaurally, K., Bezzi, P., Santello, M., Domercq, M., Matute, C., Tonello, F., Gundersen, V., & Volterra, A. (2007) · Nature Neuroscience · doi:10.1038/nn1849 · Cited by 806 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
Self-citationOrigin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 766 · see citing works
Neuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 739 · see citing works
Astrocytic complexity distinguishes the human brain
Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739 · see citing works
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate
Bezzi, P., Gundersen, V., Galbete, J. L., Seifert, G., Steinhäuser, C., Pilati, E., & Volterra, A. (2004) · Nature Neuroscience · doi:10.1038/nn1246 · Cited by 737 · see citing works
Astrocytes Potentiate Transmitter Release at Single Hippocampal Synapses
Perea, G., & Araque, A. (2007) · Science · doi:10.1126/science.1144640 · Cited by 727 · see citing works
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell, E. D., RAKIC, P. T., Kukekov, V. G., Holland, E. C., & Steindler, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250471697 · Cited by 722 · see citing works
Microdomains for neuron–glia interaction: parallel fiber signaling to Bergmann glial cells
Grosche, J., Matyash, V., Möller, T., Verkhratsky, A., Reichenbach, A., & Kettenmann, H. (1999) · Nature Neuroscience · doi:10.1038/5692 · Cited by 700 · see citing works
Self-citationGlial Calcium: Homeostasis and Signaling Function
Verkhratsky, A., Orkand, R. K., & Kettenmann, H. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.99 · Cited by 689 · see citing works
Self-citationSpontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
Parri, H. R., Gould, T. M., & Crunelli, V. (2001) · Nature Neuroscience · doi:10.1038/90507 · Cited by 625 · see citing works
New roles for astrocytes: Regulation of synaptic transmission
Newman, E. A. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00237-6 · Cited by 619 · see citing works
Mice lacking vimentin develop and reproduce without an obvious phenotype
Colucci-Guyon, E., Portier, M.-M., Dunia, I., Paulin, D., Pournin, S., & Babinet, C. (1994) · Cell · doi:10.1016/0092-8674(94)90553-3 · Cited by 598 · see citing works
Adenosine and sleep–wake regulation
Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 589 · see citing works
Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587 · see citing works
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works
Fremeau, R. T., Burman, J. L., Qureshi, T., Tran, C. H., Proctor, J. M., Johnson, J., Zhang, H., Sulzer, D. L., Copenhagen, D. R., Storm‐Mathisen, J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222546799 · Cited by 568 · see citing works
What Is the Role of Astrocyte Calcium in Neurophysiology?
Agulhon, C., Petravicz, J., McMullen, A. B., Sweger, E. J., Minton, S. K., Taves, S., Casper, K. B., Fiacco, T. A., & McCarthy, K. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.004 · Cited by 567 · see citing works
Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema
Cicardi, M., Banerji, A., Bracho, F. A., Malbrán, A., Rosenkranz, B., Riedl, M. A., Bork, K., Lumry, W. R., Aberer, W., Bier, H., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906393 · Cited by 563 · see citing works
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00221.x · Cited by 543 · see citing works
Self-citationYang, Y., Ge, W., Chen, Y., Zhang, Z., Shen, W., Wu, C., Poo, M., & Duan, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2431073100 · Cited by 533 · see citing works
Activity-dependent structural and functional plasticity of astrocyte-neuron interactions
Theodosis, D. T., Poulain, D. A., & Oliet, S. H. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00036.2007 · Cited by 531 · see citing works
Self-citationPurification of serine racemase: biosynthesis of the neuromodulator D-serine.
Wolosker, H., Sheth, K., Takahashi, M., Mothet, J., Brady, R., Ferris, C., & Snyder, S. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.2.721 · Cited by 505 · see citing works
Olabarria, M., Noristani, H. N., Verkhratsky, A., & Rodríguez, J. J. (2010) · Glia · doi:10.1002/glia.20967 · Cited by 499 · see citing works
Self-citationThe Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works
Self-citationEndocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes
Navarrete, M., & Araque, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.043 · Cited by 485 · see citing works
Astrocytic control of glutamatergic activity: astrocytes as stars of the show
Hertz, L., & Zielke, H. R. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.008 · Cited by 470 · see citing works
Mothet, J., Pollegioni, L., Ouanounou, G., Martineau, M., Fossier, P., & Baux, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408483102 · Cited by 461 · see citing works
Wilhelmsson, U., Li, L., Pekna, M., Berthold, C.-H., Blom, S., Eliasson, C., Renner, O., Bushong, E., Ellisman, M., Morgan, T. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0820-04.2004 · Cited by 455 · see citing works
Self-citationAstrocyte intermediate filaments in CNS pathologies and regeneration
Pekny, M., & Pekna, M. (2004) · The Journal of Pathology · doi:10.1002/path.1645 · Cited by 420 · see citing works
Self-citationIdentification of a vesicular nucleotide transporter
Sawada, K., Echigo, N., Juge, N., Miyaji, T., Otsuka, M., Omote, H., Yamamoto, A., & Moriyama, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800141105 · Cited by 418 · see citing works
Klunk, W. E., Bacskai, B. J., Mathis, C. A., Kajdasz, S. T., McLellan, M. E., Frosch, M. P., Debnath, M. L., Holt, D. P., Wang, Y., & Hyman, B. T. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.9.797 · Cited by 412 · see citing works
Inflammatory Process in Parkinsons Disease: Role for Cytokines
Nagatsu, T., & Sawada, M. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381620 · Cited by 412 · see citing works
Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca 2+ Signaling
Agulhon, C., Fiacco, T. A., & McCarthy, K. D. (2010) · Science · doi:10.1126/science.1184821 · Cited by 409 · see citing works
Pekny, M., Johansson, C. B., Eliasson, C., Stakeberg, J., Wallén, Å., Perlmann, T., Lendahl, U., Betsholtz, C., Berthold, C.-H., & Frisén, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.503 · Cited by 405 · see citing works
Self-citationGABAergic network activation of glial cells underlies hippocampal heterosynaptic depression
Serrano, A., Haddjeri, N., Lacaille, J.-C., & Robitaille, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5255-05.2006 · Cited by 398 · see citing works
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
Marković, D., Vinnakota, K., Chirasani, S. R., Synowitz, M., Raguet, H., Stock, K., Sliwa, M., Lehmann, S., Kälin, R. E., van Rooijen, N., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804273106 · Cited by 388 · see citing works
Graeber, M. B., Scheithauer, B. W., & Kreutzberg, G. W. (2002) · Glia · doi:10.1002/glia.10147 · Cited by 387 · see citing works
Update on connexins and gap junctions in neurons and glia in the mammalian nervous system
Nagy, J. I., Dudek, F. E., & Rash, J. E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.005 · Cited by 375 · see citing works
Wender, R., Brown, A. M., Fern, R., Swanson, R. A., Farrell, K., & Ransom, B. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06804.2000 · Cited by 374 · see citing works
Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy
Gordon, G. R. J., Baimoukhametova, D. V., Hewitt, S. A., Rajapaksha, W. R. A. K. J. S., Fisher, T. E., & Bains, J. S. (2005) · Nature Neuroscience · doi:10.1038/nn1498 · Cited by 374 · see citing works
Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503839103 · Cited by 373 · see citing works
Self-citationAutocrine Factors That Sustain Glioma Invasion and Paracrine Biology in the Brain Microenvironment
Hoelzinger, D. B., Demuth, T., & Berens, M. E. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm187 · Cited by 372 · see citing works
Gliotransmission: Exocytotic release from astrocytes
Parpura, V., & Zorec, R. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.008 · Cited by 367 · see citing works
Self-citationEnhanced synaptic connectivity and epilepsy in C1q knockout mice
Chu, Y., Jin, X., Parada, I., Pesic, A., Stevens, B., Barres, B., & Prince, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913449107 · Cited by 364 · see citing works
Vesicular Glutamate Transporter-Dependent Glutamate Release from Astrocytes
Montana, V., Ni, Y., Sunjara, V., Hua, X. J., & Parpura, V. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3770-03.2004 · Cited by 363 · see citing works
Self-citationMurray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02974.1998 · Cited by 359 · see citing works
Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., LEUVEN, F. V., & Heneka, M. T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09796.2003 · Cited by 359 · see citing works
Self-citationIntermediate Filament Protein Partnership in Astrocytes
Eliasson, C., Sahlgren, C., Berthold, C.-H., Stakeberg, J., Celis, J. E., Betsholtz, C., Eriksson, J. E., & Pekny, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23996 · Cited by 357 · see citing works
Self-citationNMDA Receptors Mediate Neuron-to-Glia Signaling in Mouse Cortical Astrocytes
Lalo, U., Pankratov, Y. V., Kirchhoff, F., North, R. A., & Verkhratsky, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4689-05.2006 · Cited by 355 · see citing works
Self-citationAutocrine Glutamate Signaling Promotes Glioma Cell Invasion
Lyons, S. A., Chung, W. J., Weaver, A. K., Ogunrinu, T., & Sontheimer, H. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2034 · Cited by 342 · see citing works
Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Berthold, C. H., Westermark, B., & Betsholtz, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07147.x · Cited by 336 · see citing works
Self-citationNitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation
Kummer, M. P., Hermes, M., Delekarte, A., Hammerschmidt, T., Kumar, S., Terwel, D., Walter, J., Pape, H.-C., König, S., Roeber, S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.001 · Cited by 336 · see citing works
Self-citationNew roles for astrocytes (stars at last)
Ransom, B. R., Behar, T. N., & Nedergaard, M. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.006 · Cited by 335 · see citing works
Lactate is a Preferential Oxidative Energy Substrate over Glucose for Neurons in Culture
Bouzier-Sore, A.-K., Voisin, P., Canioni, P., Magistretti, P. J., & Pellerin, L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000091761.61714.25 · Cited by 328 · see citing works
Tumor necrosis factor alters synaptic transmission in rat hippocampal slices.
Tancredi, V., D'Arcangelo, G., Grassi, F., Tarroni, P., Palmieri, G., Santoni, A., & Eusebi, F. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90071-e · Cited by 326 · see citing works
Vesicular transmitter release from astrocytes
Montana, V., Malarkey, E. B., Verderio, C., Matteoli, M., & Parpura, V. (2006) · Glia · doi:10.1002/glia.20367 · Cited by 325 · see citing works
Self-citationMenet, V., Prieto, M., Privat, A., & y Ribotta, M. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533187100 · Cited by 318 · see citing works
Fiacco, T. A., Agulhon, C., Taves, S., Petravicz, J., Casper, K. B., Dong, X., Chen, J., & McCarthy, K. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.032 · Cited by 316 · see citing works
Microglia Stimulate the Invasiveness of Glioma Cells by Increasing the Activity of Metalloprotease-2
Markovic, D. S., Glaß, R., Synowitz, M., van Rooijen, N., & Kettenmann, H. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178445.33972.a9 · Cited by 316 · see citing works
Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-22 · Cited by 309 · see citing works
Self-citationRelease of adenosine by activation of NMDA receptors in the hippocampus.
Manzoni, O. J., Manabe, T., & Nicoll, R. (1994) · Science · doi:10.1126/science.7916485 · Cited by 306 · see citing works
Barkho, B. Z., Song, H., Aimone, J. B., Smrt, R. D., Kuwabara, T., Nakashima, K., Gage, F. H., & Zhao, X. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.407 · Cited by 303 · see citing works
Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging
Shulman, R. G., Hyder, F., & Rothman, D. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101129298 · Cited by 299 · see citing works
Imaging Extracellular Waves of Glutamate during Calcium Signaling in Cultured Astrocytes
Innocenti, B., Parpura, V., & Haydon, P. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01800.2000 · Cited by 294 · see citing works
Self-citationAstroglial processes show spontaneous motility at active synaptic terminals in situ
Hirrlinger, J., Hülsmann, S., & Kirchhoff, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03689.x · Cited by 288 · see citing works
Neuron-derived D-Serine Release Provides a Novel Means to Activate N-Methyl-D-aspartate Receptors
Kartvelishvily, E., Shleper, M., Balan, L., Dumin, E., & Wolosker, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512927200 · Cited by 277 · see citing works
Verkhratsky, A., & Kirchhoff, F. (2007) · The Neuroscientist · doi:10.1177/1073858406294270 · Cited by 265 · see citing works
Self-citationThrombospondins 1 and 2 are Necessary for Synaptic Plasticity and Functional Recovery after Stroke
Liauw, J. A., Hoang, S., Choi, M. Y., Eroğlu, Ç., Choi, M., Sun, G.-H., Percy, M., Wildman‐Tobriner, B., Bliss, T. M., Guzman, R. G., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.65 · Cited by 263 · see citing works
Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens
Gibbs, M. E., Anderson, D. G., & Hertz, L. (2006) · Glia · doi:10.1002/glia.20377 · Cited by 251 · see citing works
VGLUTs: ‘Exciting’ times for glutamatergic research?
Takamori, S. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.04.016 · Cited by 249 · see citing works
Fusion-related Release of Glutamate from Astrocytes
Zhang, Q., Pangršič, T., Kreft, M., Kržan, M., Li, N., Sul, J., Halassa, M. M., Bockstaele, E. V., Zorec, R., & Haydon, P. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312845200 · Cited by 246 · see citing works
Self-citationExocytotic Release of ATP from Cultured Astrocytes
Pangršič, T., Potokar, M., Stenovec, M., Kreft, M., Fabbretti, E., Nistri, A., Pryazhnikov, E., Khiroug, L. S., Giniatullin, R. A., & Zorec, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700290200 · Cited by 245 · see citing works
Self-citationThe problem of astrocyte identity
Kimelberg, H. K. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.08.015 · Cited by 244 · see citing works
Glutamate receptors in glia: new cells, new inputs and new functions
Gallo, V., & Ghiani, C. A. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01494-2 · Cited by 244 · see citing works
ATP Mediates Calcium Signaling Between Astrocytes and Microglial Cells: Modulation by IFN-γ
Verderio, C., & Matteoli, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.10.6383 · Cited by 242 · see citing works
Connexin and pannexin mediated cell–cell communication
Scemes, E., Suadicani, S. O., Dahl, G., & Spray, D. C. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000069 · Cited by 233 · see citing works
Self-citationGlial Glycogen Stores Affect Neuronal Survival during Glucose Deprivation in vitro
Swanson, R. A., & Choi, D. W. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.19 · Cited by 231 · see citing works
Tripartite synapses: Roles for astrocytic purines in the control of synaptic physiology and behavior
Halassa, M. M., Fellin, T., & Haydon, P. G. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.031 · Cited by 229 · see citing works
Self-citationRobust neural integration from retinal transplants in mice deficient in GFAP and vimentin
Kinouchi, R., Takeda, M., Yang, L., Wilhelmsson, U., Lundkvist, A., Pekny, M., & Chen, D. F. (2003) · Nature Neuroscience · doi:10.1038/nn1088 · Cited by 229 · see citing works
Self-citationCapacitative calcium entry in parotid acinar cells
Takemura, H., & Putney, J. W. (1989) · Biochemical Journal · doi:10.1042/bj2580409 · Cited by 227 · see citing works
Current concepts of blood-brain barrier development
Liebner, S., Czupalla, C. J., & Wolburg, H. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103224sl · Cited by 227 · see citing works
Glial transporters for glutamate, glycine and GABA I. Glutamate transporters
Gadea, A., & López-Colomé, A. M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1039 · Cited by 227 · see citing works
Invadopodia: At the cutting edge of tumour invasion
Stylli, S. S., Kaye, A. H., & Lock, P. (2008) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.03.003 · Cited by 222 · see citing works
The Neuroglia Elements in the Human Brain
ANDRIEZEN, W. L. (1893) · BMJ · doi:10.1136/bmj.2.1700.227 · Cited by 222 · see citing works
Zagzag, D., Esencay, M., Méndez, O., Yee, H. T., Smirnova, I., Huang, Y., Chiriboga, L. A., Lukyanov, E., Liu, M., & Newcomb, E. W. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071197 · Cited by 216 · see citing works
Synaptotagmin IV regulates glial glutamate release
Zhang, Q., Fukuda, M., Bockstaele, E. V., Pascual, O., & Haydon, P. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401960101 · Cited by 208 · see citing works
Self-citationPhysiologic coupling of glial glycogen metabolism to neuronal activity in brain
Swanson, R. A. (1992) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y92-255 · Cited by 207 · see citing works
Emerging complexities in identity and function of glial connexins
Theis, M., Söhl, G., Eiberger, J., & Willecke, K. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.02.006 · Cited by 205 · see citing works
Bal‐Price, A., Moneer, Z., & Brown, G. C. (2002) · Glia · doi:10.1002/glia.10124 · Cited by 204 · see citing works
Glia‐derived signals induce synapse formation in neurones of the rat central nervous system
Nägler, K., Mauch, D. H., & Pfrieger, F. W. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00665.x · Cited by 203 · see citing works
Bradykinin Promotes the Chemotactic Invasion of Primary Brain Tumors
Montana, V., & Sontheimer, H. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3825-10.2011 · Cited by 201 · see citing works
Self-citationGlial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex
Fossat, P., Turpin, F. R., Sacchi, S., Dulong, J., Shi, T., Rivet, J., Sweedler, J. V., Pollegioni, L., Millan, M. J., Oliet, S. H. R., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr130 · Cited by 185 · see citing works
Self-citationTerwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & Heneka, M. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6546-10.2011 · Cited by 181 · see citing works
Self-citationSuh, S. W., Bergher, J. P., Anderson, C. M., Treadway, J. L., Fosgerau, K., & Swanson, R. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115550 · Cited by 178 · see citing works
Role of glutamate in neuron-glia metabolic coupling
Magistretti, P. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462cc · Cited by 178 · see citing works
Intermediate filaments and stress
Pekny, M., & Lane, E. B. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.04.023 · Cited by 174 · see citing works
Self-citationProperties of Ca2+‐dependent exocytosis in cultured astrocytes
Kreft, M., Stenovec, M., Rupnik, M. S., Grilc, S., Kržan, M., Potokar, M., Pangršič, T., Haydon, P. G., & Zorec, R. (2004) · Glia · doi:10.1002/glia.20018 · Cited by 174 · see citing works
Self-citationMalarkey, E. B., Ni, Y., & Parpura, V. (2008) · Glia · doi:10.1002/glia.20656 · Cited by 171 · see citing works
Self-citationShibata, N., Motoi, Y., Tomiyama, H., Ohnuma, T., Kuerban, B., Tomson, K., Komatsu, M., Shimazaki, H., Hattori, N., & Arai, H. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000351419 · Cited by 171 · see citing works
P2X1and P2X5Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes
Lalo, U., Pankratov, Y. V., Wichert, S. P., Rossner, M. J., North, R. A., Kirchhoff, F., & Verkhratsky, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1149-08.2008 · Cited by 171 · see citing works
Self-citationMolecular mechanisms of inherited demyelinating neuropathies
Scherer, S. S., & Wrabetz, L. G. (2008) · Glia · doi:10.1002/glia.20751 · Cited by 171 · see citing works
Bak, L. K., Schousboe, A., Sonnewald, U., & Waagepetersen, H. S. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600281 · Cited by 170 · see citing works
Self-citationBrown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169 · see citing works
Self-citationRe-establishing the regenerative potential of central nervous system axons in postnatal mice
Cho, K.-S., Yang, L., Lu, B., Feng Ma, H., Huang, X., Pekny, M., & Chen, D. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.01658 · Cited by 164 · see citing works
Self-citationGandhi, G. K., Cruz, N. F., Ball, K. K., & Dienel, G. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06333.x · Cited by 162 · see citing works
Palygin, O., Lalo, U., Verkhratsky, A., & Pankratov, Y. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.09.004 · Cited by 160 · see citing works
Self-citationNeuron–astrocyte signaling and epilepsy
Seifert, G., & Steinhäuser, C. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.024 · Cited by 156 · see citing works
ATP-induced cytoplasmic calcium mobilization in Bergmann glial cells
Kirischuk, S., Moller, T., Voitenko, N. V., Kettenmann, H., & Verkhratsky, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07861.1995 · Cited by 156 · see citing works
Self-citationSynaptically induced sodium signals in hippocampal astrocytes in situ
Langer, J., & Rose, C. R. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.182279 · Cited by 155 · see citing works
Properties of K + and Cl − channels and their involvement in proliferation of rat microglial cells
Schlichter, L. C., Sakellaropoulos, G., Ballyk, B. A., Pennefather, P., & Phipps, D. J. (1996) · Glia · doi:10.1002/(sici)1098-1136(199607)17:3 · Cited by 150 · see citing works
Minelli, A., Castaldo, P., Gobbi, P., Salucci, S., Magi, S., & Amoroso, S. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.06.004 · Cited by 149 · see citing works
Astrocyte responses to neuronal activity
Schipke, C. G., & Kettenmann, H. (2004) · Glia · doi:10.1002/glia.20029 · Cited by 149 · see citing works
Heneka, M. T., Wiesinger, H., Dumitrescu‐Ozimek, L., Riederer, P. F., Feinstein, D. L., & Klockgether, T. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.906 · Cited by 147 · see citing works
Self-citationBowser, D. N., & Khakh, B. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607625104 · Cited by 146 · see citing works
Golovina, V. A. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.085035 · Cited by 140 · see citing works
Glutamate Uptake Triggers Transporter-Mediated GABA Release from Astrocytes
Héja, L., Barabás, P., Nyitrai, G., Kékesi, K. A., Lasztóczi, B., Tőke, O., Tárkányi, G., Madsen, K. K., Schousboe, A., Dobolyi, Á., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007153 · Cited by 137 · see citing works
Self-citationPhysiology of neuronal–glial networking
Verkhratsky, A. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.002 · Cited by 136 · see citing works
Self-citationDirect evidence for expression of dopamine receptors in astrocytes from basal ganglia
Miyazaki, I., Asanuma, M., Diaz-Corrales, F. J. J., Miyoshi, K., & Ogawa, N. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.014 · Cited by 134 · see citing works
Excitatory amino acid-stimulated uptake of 22Na+ in primary astrocyte cultures
Kimelberg, H., Pang, S., & Treble, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-04-01141.1989 · Cited by 134 · see citing works
Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents
Walls, A. B., Heimbürger, C. M., Bouman, S. D., Schousboe, A., & Waagepetersen, H. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.058 · Cited by 133 · see citing works
Self-citationIfuku, M., Färber, K., Okuno, Y., Yamakawa, Y., Miyamoto, T., Nolte, C., Merrino, V., Kita, S., Iwamoto, T., Komuro, I., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3467-07.2007 · Cited by 131 · see citing works
Kirischuk, S., Kettenmann, H., & Verkhratsky, A. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0207-5 · Cited by 129 · see citing works
Self-citationDienel, G. A., Ball, K. K., & Cruz, N. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04595.x · Cited by 127 · see citing works
Na + /Ca 2+ exchanger modulates kainate‐triggered Ca 2+ signaling in Bergmann glial cells in situ
Kirischuk, S., Kettenmann, H., & Verkhratsky, A. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212080 · Cited by 124 · see citing works
Self-citationGap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ
Langer, J., Stephan, J., Theis, M., & Rose, C. R. (2011) · Glia · doi:10.1002/glia.21259 · Cited by 124 · see citing works
Rosenberg, D., Kartvelishvily, E., Shleper, M., Klinker, C. C., Bowser, M. T., & Wolosker, H. (2010) · The FASEB Journal · doi:10.1096/fj.09-147967 · Cited by 123 · see citing works
Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes
Palygin, O., Lalo, U., & Pankratov, Y. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01374.x · Cited by 121 · see citing works
Tancredi, V., Zona, C., Velotti, F., Eusebi, F., & Santoni, A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91331-a · Cited by 121 · see citing works
Sodium/calcium exchange in rat cortical astrocytes
Goldman, W. F., Yarowsky, P., Juhaszova, M., Krueger, B., & Blaustein, M. P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-05834.1994 · Cited by 117 · see citing works
Calcium-Dependent Exocytosis of Atrial Natriuretic Peptide from Astrocytes
Kržan, M., Stenovec, M., Kreft, M., Pangršič, T., Grilc, S., Haydon, P. G., & Zorec, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01580.2003 · Cited by 117 · see citing works
Self-citationFunctional significance of brain glycogen in sustaining glutamatergic neurotransmission
Sickmann, H. M., Walls, A. B., Schousboe, A., Bouman, S. D., & Waagepetersen, H. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05915.x · Cited by 116 · see citing works
Self-citationLalo, U., Pankratov, Y., Parpura, V., & Verkhratsky, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.007 · Cited by 116 · see citing works
Self-citationHua, X. J., Malarkey, E. B., Sunjara, V., Rosenwald, S. E., Li, W., & Parpura, V. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20061 · Cited by 115 · see citing works
Self-citationMarchaland, J., Calì, C., Voglmaier, S. M., Li, H., Regazzi, R., Edwards, R. H., & Bezzi, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0040-08.2008 · Cited by 113 · see citing works
Confocal imaging and tracking of the exocytotic routes for D ‐serine‐mediated gliotransmission
Martineau, M., Galli, T., Baux, G., & Mothet, J. (2008) · Glia · doi:10.1002/glia.20696 · Cited by 109 · see citing works
Kirischuk, S., Tuschick, S., Verkhratsky, A., & Kettenmann, H. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01288.x · Cited by 109 · see citing works
Self-citationMinocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression
Marković, D., Vinnakota, K., van Rooijen, N., Kiwit, J., Synowitz, M., Glass, R., & Kettenmann, H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.015 · Cited by 105 · see citing works
Reyes, R. C., Verkhratsky, A., & Parpura, V. (2012) · ASN NEURO · doi:10.1042/an20110059 · Cited by 103 · see citing works
Self-citationIonotropic glutamate receptors in astrocytes
Seifert, G., & Steinhäuser, C. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)32083-6 · Cited by 102 · see citing works
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
Dai, H., Shin, O., Machius, M., Tomchick, D., Südhof, T., & Rizo, J. (2004) · Nature Structural &Molecular Biology · doi:10.1038/nsmb817 · Cited by 102 · see citing works
Widestrand, Å., Faijerson, J., Wilhelmsson, U., Smith, P. L. P., Li, L., Sihlbom, C., Eriksson, P. S., & Pekny, M. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0122 · Cited by 100 · see citing works
Self-citationAge-dependent remodelling of ionotropic signalling in cortical astroglia
Lalo, U., Palygin, O., North, R. A., Verkhratsky, A., & Pankratov, Y. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00682.x · Cited by 99 · see citing works
Self-citationHsieh, H., Wu, C., & Yang, C. (2008) · Glia · doi:10.1002/glia.20637 · Cited by 97 · see citing works
Ion changes and signalling in perisynaptic glia
Deitmer, J. W., & Rose, C. R. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.006 · Cited by 96 · see citing works
Pihlaja, R., Koistinaho, J., Kauppinen, R., Sandholm, J., Tanila, H., & Koistinaho, M. (2011) · Glia · doi:10.1002/glia.21212 · Cited by 96 · see citing works
Conti, F., Minelli, A., & Brecha, N. C. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500208 · Cited by 95 · see citing works
Localization of SNARE proteins and secretory organelle proteins in astrocytes in vitro and in situ
Wilhelm, A., Volknandt, W., Langer, D. J., Nolte, C., Kettenmann, H., & Zimmermann, H. (2003) · Neuroscience Research · doi:10.1016/j.neures.2003.11.002 · Cited by 94 · see citing works
Handbuch der Gewebelehre des Menschen : für Aerzte und Studirende
Kölliker, A. (1863) · Cited by 92 · see citing works
Calcium release from intracellular stores in rodent astrocytes and neurons in situ
Beck, A., Nieden, R. Z., Schneider, H.-P., & Deitmer, J. W. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00171-4 · Cited by 92 · see citing works
Schipke, C. G., Haas, B., & Kettenmann, H. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn009 · Cited by 91 · see citing works
Mitochondria Modulate Ca2+-Dependent Glutamate Release from Rat Cortical Astrocytes
Reyes, R. C., & Parpura, V. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3484-08.2008 · Cited by 87 · see citing works
Self-citationVesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons
Ni, Y., Malarkey, E. B., & Parpura, V. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04864.x · Cited by 87 · see citing works
Self-citationGLIAL-NEURONAL INTERACTIONS IN THE MAMMALIAN BRAIN
Hatton, G. I. (2002) · AJP Advances in Physiology Education · doi:10.1152/advan.00038.2002 · Cited by 87 · see citing works
Lynch, R. M., Fogarty, K. E., & Fay, F. S. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.112.3.385 · Cited by 85 · see citing works
The origins of glioma: E Pluribus Unum?
Siebzehnrübl, F. A., Reynolds, B. A., Vescovi, A. L., Steindler, D. A., & Deleyrolle, L. P. (2011) · Glia · doi:10.1002/glia.21143 · Cited by 83 · see citing works
Rojas, H., Colina, C., Ramos, M., Benaím, G., Jaffe, E. H., Caputo, C. A., & DiPolo, R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04303.x · Cited by 81 · see citing works
Oliveira, J. F., Riedel, T., Leichsenring, A., Heine, C., Franke, H., Krügel, U., Nörenberg, W., & Illés, P. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq154 · Cited by 81 · see citing works
Matsuda, T., Takuma, K., Nishiguchi, E., et al. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01582.x · Cited by 80 · see citing works
Reichenbach, A. (1989) · Glia · doi:10.1002/glia.440020406 · Cited by 79 · see citing works
Self-citationWhere the thoughts dwell: The physiology of neuronal–glial “diffuse neural net”
Verkhratsky, A., Parpura, V., & Rodriguez, J. J. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.05.002 · Cited by 79 · see citing works
Self-citationPaluzzi, S., Alloisio, S., Zappettini, S., Milanese, M., Raiteri, L., Nobile, M., & Bonanno, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04826.x · Cited by 74 · see citing works
Walls, A. B., Sickmann, H. M., Brown, A. M., Bouman, S. D., Ransom, B. R., Schousboe, A., & Waagepetersen, H. S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05250.x · Cited by 73 · see citing works
Self-citationKirischuk, S., Kirchhoff, F., Matyash, V., Kettenmann, H., & Verkhratsky, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00067-6 · Cited by 71 · see citing works
Self-citationExpression of Glycine Receptor Subunits in Glial Cells of the Rat Spinal Cord
Kirchhoff, F., Mülhardt, C., Pastor, A., et al. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041383.x · Cited by 71 · see citing works
Bennay, M., Langer, J., Meier, S. D., Kafitz, K. W., & Rose, C. R. (2008) · Glia · doi:10.1002/glia.20685 · Cited by 70 · see citing works
Deng, Q., Terunuma, M., Fellin, T., Moss, S. J., & Haydon, P. G. (2011) · Glia · doi:10.1002/glia.21181 · Cited by 70 · see citing works
Self-citationNi, Y., & Parpura, V. (2009) · Glia · doi:10.1002/glia.20849 · Cited by 69 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Chao TI Rickmann M Wolff JR Volterra A Magistretti P Haydon PG 2002 The synapse-astrocyte boundary: anatomical basis for an integrative role of glia in synaptic transmission Tripartite synapses: Synaptic transmission with glia 3 23 Oxford University Press Oxford-New York
- Dermietzel R Spray DC Scemes E Spray DC 2012 Blood-brain barrier and the neural vascular unit Astrocytes: Wiring the brain 179 203 CRC Press Boca Raton, FL
- Vogt C Vogt O 1937 Sitz und Wesen der Krankheiten im Lichte der topistischen Hirnforschung und des Variierens der Tiere. Erster Teil: Befunde der topistischen Hirnforschung als Beitrag zur Lehre vom Krankheitssitz Journal für Psychologie und Neurologie 47 238 457
Cited by
Sorted by citations
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works
Self-citationThe role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375 · see citing works
“Astrocytes are implicated in various CNS disorders, e.g., Alzheimer's disease (Parpura et al., 2012) and demyelinating disorders such as neuromyelitis optica and MS (Nair et al., 2008; Kipp et al., 2011a) .”
BackgroundInfluentialStratification of astrocytes in healthy and diseased brain
Verkhratsky, A., Zorec, R., & Parpura, V. (2017) · Brain Pathology · doi:10.1111/bpa.12537 · Cited by 236 · see citing works
Self-citationGarwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works
The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.-A., Ben Haim, L., & Escartin, C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.043 · Cited by 185 · see citing works
Amyloid beta deregulates astroglial mGluR5‐mediated calcium signaling via calcineurin and Nf‐kB
Lim, D., Iyer, A., Ronco, V., Grolla, A. A., Canonico, P. L., Aronica, E., & Genazzani, A. A. (2013) · Glia · doi:10.1002/glia.22502 · Cited by 169 · see citing works
Astroglia In Neurological Diseases
Verkhratsky, A., Rodríguez, J. J., & Parpura, V. (2013) · Future Neurology · doi:10.2217/fnl.12.90 · Cited by 140 · see citing works
Self-citationTripathi, P., Rodriguez-Muela, N., Klim, J. R., de Boer, A. S., Agrawal, S., Sandoe, J., Lopes, C. S., Ogliari, K. S., Williams, L. A., Shear, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.008 · Cited by 123 · see citing works
Targeting innate immunity for neurodegenerative disorders of the central nervous system
Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126 · see citing works
Self-citationAstrocyte–neuron interplay in maladaptive plasticity.
Papa, M., De Luca, C., Petta, F., Alberghina, L., & Cirillo, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.010 · Cited by 104 · see citing works
Pirttimaki, T. M., Codadu, N. K., Awni, A., Pratik, P., Nagel, D. A., Hill, E. J., Dineley, K. T., & Parri, H. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081828 · Cited by 103 · see citing works
Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain · doi:10.1186/s13041-015-0138-6 · Cited by 101 · see citing works
From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation
Bajic, J. E., Johnston, I. N., Howarth, G. S., & Hutchinson, M. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00104 · Cited by 100 · see citing works
Fluoxetine Requires the Endfeet Protein Aquaporin-4 to Enhance Plasticity of Astrocyte Processes
Di Benedetto, B., Malik, V. A., Begum, S., Jablonowski, L., Gómez-González, G. B., Neumann, I. D., & Rupprecht, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00008 · Cited by 77 · see citing works
Properties of human astrocytes and NG2 glia
Bedner, P., Jabs, R., & Steinhäuser, C. (2020) · Glia · doi:10.1002/glia.23725 · Cited by 71 · see citing works
Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder
Pfaffenseller, B., Fries, G. R., Wollenhaupt-Aguiar, B., Colpo, G. D., Stertz, L., Panizzutti, B., Magalhães, P. V., & Kapczinski, F. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811981 · Cited by 68 · see citing works
Gatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13281 · Cited by 58 · see citing works
Kerman, I. A., Bernard, R., Bunney, W. E., Jones, E. G., Schatzberg, A. F., Myers, R. M., Barchas, J. D., Akil, H., Watson, S. J., & Thompson, R. C. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00135 · Cited by 59 · see citing works
Astroglial Calcium Signalling in Alzheimer's Disease
Verkhratsky, A., Rodríguez-Arellano, J. J., Parpura, V., & Zorec, R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.088 · Cited by 55 · see citing works
Self-citationChocyk, A., Majcher-Maślanka, I., Dudys, D., Przyborowska, A., & Wędzony, K. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71506-8 · Cited by 55 · see citing works
Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia
Leanza, G., Gulino, R., & Zorec, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00254 · Cited by 54 · see citing works
Self-citationMathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE · doi:10.1371/journal.pone.0118463 · Cited by 52 · see citing works
Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders
Kaminsky, N., Bihari, O., Kanner, S., & Barzilai, A. (2016) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.04.003 · Cited by 38 · see citing works
- Authors
- Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., Pekny, M., Pekna, M., Zorec, R., & Verkhratsky, A.
- Affiliations
- Ikerbasque (ES)
- University of Bonn (DE)
- University of Alabama (US)
- Université de Bordeaux (FR)
- University of Copenhagen (DK)
- Tufts University (US)
- Albert Einstein College of Medicine (US)
- Leipzig University (DE)
- University of Gothenburg (SE)
- University of Ljubljana (SI)
- Corresponding author
- Parpura, Vladimir
- Verkhratsky, Alexei
- ORCID
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2012-02-02
- Volume
- 121
- Issue
- 1
- Pages
- 4-27
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- PMC
- PMC3304021
- OpenAlex
- W1549972124
- Cited by
- 561
- References
- 224
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 22 · 2023: 33 · 2022: 29 · 2021: 36 · 2020: 22 · 2019: 26 · 2018: 38 · 2017: 37 · 2016: 48 · 2015: 67 · 2014: 76 · 2013: 59 · 2012: 29
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Science Foundation (0943343)
- Judith Jane Mason and Harold Stannett Williams Memorial Foundation
- Alzheimer's Research Trust (ART/PG2004A/1)
- Deutsche Forschungsgemeinschaft (GRK 1097)
- Grantová Agentura České Republiky (GACR 305/08/1381)
- Javna Agencija za Raziskovalno Dejavnost RS (P3-310)
- International Society for Neurochemistry
- Medical Research Council
- National Institute on Drug Abuse (R01DA025967, DA025967)
- National Institute of Neurological Disorders and Stroke (NS-037585, R01NS037585, R37NS037585)
- Division of Chemical, Bioengineering, Environmental, and Transport Systems
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- astrocytes, glial cells, tripartite synapse, astrocyte calcium signaling, gliotransmitters, synaptic plasticity, neurogenesis, brain homeostasis, Alzheimer's disease, glioma, tumor invasion, astrocyte-neuron interaction, neurotransmitter homeostasis
- MeSH terms
- Alzheimer Disease, Animals, Humans, Synaptic Transmission, Neuroglia, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review