Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair
Open accessAbstract
Cutaneous wounds persist as a health care crisis in spite of increased understanding of the cellular and molecular responses to injury. Contributing significantly to this crisis is the lack of reliable therapies for treatment of wounds that are slow to heal including chronic wounds and deep dermal wounds that develop hypertrophic scars. This article will review the growing evidence demonstrating the promise of multipotent mesenchymal stem/stromal (MSCs) for the treatment of impaired wound healing. MSCs are often referred to as mesenchymal stem cells despite concerns that these cells are not truly stem cells given the lack of evidence demonstrating self-renewal in vivo. Regardless, abundant evidence demonstrates the therapeutic potential of MSCs for repair and regeneration of damaged tissue due to injury or disease. To date, MSC treatment of acute and chronic wounds results in accelerated wound closure with increased epithelialization, granulation tissue formation and angiogenesis. Although there is evidence for MSC differentiation in the wound, most of the therapeutic effects are likely due to MSCs releasing soluble factors that regulate local cellular responses to cutaneous injury. Important challenges need to be overcome before MSCs can be used effectively to treat wounds that are slow to heal.
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BM-MSCs exert their principal therapeutic actions through the secretion of paracrine trophic signals.
“the BM-MSCs appear to exert their principal therapeutic actions through the secretion of paracrine trophic signals [7].”
From Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice (2014) · cites this paper as [7]
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- Authors
- Hocking, A. M., & Gibran, N. S.
- Affiliations
- University of Washington (US)
- Corresponding author
- Hocking, Anne M.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 316
- Issue
- 14
- Pages
- 2213-2219
- ISSN
- 0014-4827 (ISSN-L)
- PMC
- PMC2902653
- OpenAlex
- W2084565323
- Cited by
- 408
- References
- 46
- Citations by year
- 2026: 14 · 2025: 7 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 30 · 2020: 34 · 2019: 31 · 2018: 40 · 2017: 36 · 2016: 39 · 2015: 27 · 2014: 28 · 2013: 29 · 2012: 17
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM073624)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, skin wound healing, chronic wounds, paracrine signaling, cell differentiation, hypertrophic scars, angiogenesis, granulation tissue, re-epithelialization, delayed wound healing, tissue regeneration
- MeSH terms
- Humans, Wound Healing, Signal Transduction, Paracrine Communication, Cell Proliferation, Mesenchymal Stem Cells
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