Cited by 349Wound Healing and TreatmentsMesenchymal stem cell researchNeuropeptides and Animal Physiology

A new role of substance P as an injury-inducible messenger for mobilization of CD29+ stromal-like cells

Hong, Hyun Sook, Lee, Jungsun, Lee, EunAh, Kwon, Young Sam, Lee, Eunkyung, Ahn, Woosung, Jiang, Mei Hua, Kim, Jae Chan +1 more·2009·Nature Medicine

Abstract

Tissue injury may create a specific microenvironment for inducing the systemic participation of stromal-like cells in the repair process. Here we show that substance P is an injury-inducible factor that acts early in the wound healing process to induce CD29(+) stromal-like cell mobilization. Likewise, mobilization of such cells also occurs in uninjured mice, rats and rabbits if substance P is intravenously injected. Upon further characterization these substance P-mobilized CD29(+) cells were found to be similar to stromal cells from a number of connective tissues, including bone marrow (that is, bone marrow stromal cells, or BMSCs). Both substance P injection and transfusion of autologously derived substance P-mobilized CD29(+) cells from uninjured rabbits accelerated wound healing in an alkali burn model. Also, epithelial engraftment of the transfused cells into the injured tissue occurred during the wound healing. Finally, using human BMSCs as a test population, we show that substance P stimulates transmigration, cell proliferation, activation of the extracellular signal-related kinases (Erk) 1 and 2 and nuclear translocation of beta-catenin in vitro. This finding highlights a previously undescribed function of substance P as a systemically acting messenger of injury and a mobilizer of CD29(+) stromal-like cells to participate in wound healing.

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Crossref · 10.1038/nm.1909

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Authors
Hong, H. S., Lee, J., Lee, E., Kwon, Y. S., Lee, E., Ahn, W., Jiang, M. H., Kim, J. C., & Son, Y.
Affiliations
  • Kyung Hee University (KR)
  • Chung-Ang University Hospital (KR)
Corresponding author
  • Kim, Jae Chan
  • Son, Youngsook
Venue
Nature Medicine
Published
2009-03-08
Volume
15
Issue
4
Pages
425-435
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2015214016
Cited by
349
References
46
Citations by year
2026: 4 · 2025: 12 · 2024: 9 · 2023: 21 · 2022: 22 · 2021: 22 · 2020: 26 · 2019: 29 · 2018: 25 · 2017: 34 · 2016: 33 · 2015: 25 · 2014: 32 · 2013: 17 · 2012: 16
FWCI
12.90
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
substance P, mesenchymal stem cells, wound healing, tissue damage, cell mobilization, alkali burn, ERK signaling, β-catenin nuclear translocation, cell transmigration, cell proliferation
MeSH terms
Animals, Bone Marrow Cells, Cell Movement, Eye Injuries, Interleukin-1, Rabbits, Regeneration, RNA, Messenger, Substance P, Tumor Necrosis Factor-alpha, Wound Healing, Stromal Cells, Integrin beta1, Hematopoietic Stem Cell Mobilization, Pluripotent Stem Cells, beta Catenin, Mice, Hypoxia-Inducible Factor 1, alpha Subunit

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