CoChat
Sign Up
Cited by 54

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3

Guo, Dong, Ma, Ji, Li, Tengfei, Yan, Lei·2018·Experimental Cell Research
DOI 10.1016/j.yexcr.2018.04.027
Open this paper in CoChat — free account

Abstract

Dysfunction of the microRNA (miRNA) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells after oxygen-glucose deprivation (OGD) and mouse brain after transient middle cerebral artery occlusion (MCAO). OGD treatment significantly increased N2A cell death and Caspase-3 activity, and decreased Bcl-2 protein expression. In addition, MCAO treatment induced severe mouse brain infarction, mitochondrial reactive oxygen species (ROS) production, and long-term neurological deficit. Gain-of-miR-122 function significantly suppressed OGD- and MCAO-induced injures in vitro and in vivo. Subsequently, miR-122 was validated to directly bind to the predicted 3'-untranslated region (3'-UTR) of FOXO3 gene, and the inhibitory effects of miR-122 on ischemic injury in vitro and in vivo were overturned by FOXO3 overexpression. Moreover, our results further revealed that miR-122-FOXO3 axis functioned via the heat shock protein 70 (HSP-70)-mediated NF-κB pathway. Collectively, our data suggest that miR-122 inhibits ischemic neuronal death through the HSP-70-dependent NF-κB pathway by targeting FOXO3. These findings raise the possibility that this regulatory net may contribute to the pathogenesis of the ischemic brain i…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.yexcr.2018.04.027

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 43

  1. Carelli, 2014, Mitochondrial DNA: impacting central and peripheral nervous systems, Neuron, 84, 1126, 10.1016/j.neuron.2014.11.022 · DOI
  2. George, 2015, Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments, Neuron, 87, 297, 10.1016/j.neuron.2015.05.041 · DOI
  3. Mattiasson, 2003, Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma, Nat. Med., 9, 1062, 10.1038/nm903 · DOI · Paper page
  4. Pei, 2014, DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death, J. Neurosci., 34, 6546, 10.1523/JNEUROSCI.5119-13.2014 · DOI
  5. Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res., 19, 92, 10.1101/gr.082701.108 · DOI · Paper page
  6. Pal, 2017, Animal models to study MicroRNA function, Adv. Cancer Res., 135, 53, 10.1016/bs.acr.2017.06.006 · DOI
  7. Yin, 2010, miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia, Neurobiol. Dis., 38, 17, 10.1016/j.nbd.2009.12.021 · DOI
  8. Khanna, 2013, Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size, J. Cereb. Blood Flow Metab., 33, 1197, 10.1038/jcbfm.2013.68 · DOI
  9. Huang, 2015, miR-134 regulates ischemia/reperfusion injury-induced neuronal cell death by regulating CREB signaling, J. Mol. Neurosci., 55, 821, 10.1007/s12031-014-0434-0 · DOI
  10. Sun, 2013, MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke, CNS Neurosci. Ther., 19, 813, 10.1111/cns.12142 · DOI
  11. Wang, 2014, MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression, Tumour Biol., 35, 8565, 10.1007/s13277-014-2089-4 · DOI
  12. Jickling, 2014, microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets, PLoS One, 9, e99283, 10.1371/journal.pone.0099283 · DOI
  13. Yang, 1997, Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury, Brain Res., 751, 181, 10.1016/S0006-8993(96)01277-2 · DOI
  14. Ouyang, 2012, miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo, Neurobiol. Dis., 45, 555, 10.1016/j.nbd.2011.09.012 · DOI
  15. Metz, 2002, Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination, J. Neurosci. Methods, 115, 169, 10.1016/S0165-0270(02)00012-2 · DOI
  16. Tatlisumak, 1996, Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging, Stroke, 27, 2292, 10.1161/01.STR.27.12.2292 · DOI
  17. Cui, 2014, Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats, J. Surg. Res., 192, 564, 10.1016/j.jss.2014.05.060 · DOI
  18. Ye, 2011, Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice, Neuropharmacology, 61, 815, 10.1016/j.neuropharm.2011.05.029 · DOI
  19. Kim, 2005, Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression, FASEB J., 19, 1042, 10.1096/fj.04-2841fje · DOI
  20. Coulouarn, 2009, Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties, Oncogene, 28, 3526, 10.1038/onc.2009.211 · DOI
  21. Fornari, 2009, MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells, Cancer Res., 69, 5761, 10.1158/0008-5472.CAN-08-4797 · DOI
  22. Chen, 2013, miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease, Biochem. Biophys. Res. Commun., 438, 133, 10.1016/j.bbrc.2013.07.040 · DOI
  23. Wang, 2012, MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R, PLoS One, 7, e47053, 10.1371/journal.pone.0047053 · DOI
  24. Manfè, 2012, miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma, PLoS One, 7, e29541, 10.1371/journal.pone.0029541 · DOI
  25. Liu d, 2016, Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats, J. Cereb. Blood Flow Metab., 36, 1374, 10.1177/0271678X15610786 · DOI
  26. Mattson, 2001, NF-kappaB in neuronal plasticity and neurodegenerative disorders, J. Clin. Investig., 107, 247, 10.1172/JCI11916 · DOI · Paper page
  27. Lawrence, 2009, The nuclear factor NF-kappaB pathway in inflammation, Cold Spring Harb. Perspect. Biol., 1, a001651, 10.1101/cshperspect.a001651 · DOI
  28. Smith, 2012, Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases, Brain Res Bull., 87, 10, 10.1016/j.brainresbull.2011.10.004 · DOI · Paper page
  29. Mattson, 2006, Roles for NF-kappaB in nerve cell survival, plasticity, and disease, Cell Death Differ., 13, 852, 10.1038/sj.cdd.4401837 · DOI
  30. Mattson, 2005, NF-kappaB in the survival and plasticity of neurons, Neurochem. Res., 30, 883, 10.1007/s11064-005-6961-x · DOI
  31. Tao, 2013, Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3, J. Biol. Chem., 288, 17214, 10.1074/jbc.M112.445965 · DOI
  32. Cho, 2015, Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism, Oncotarget, 6, 43, 10.18632/oncotarget.2723 · DOI
  33. Samuel, 2008, Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity, J. Agric. Food Chem., 56, 9692, 10.1021/jf802050h · DOI
  34. Song, 2015, Glutathione suppresses cerebral infarct volume and cell death after ischemic injury: involvement of FOXO3 inactivation and Bcl2 expression, Oxid. Med. Cell Longev., 2015, 426069, 10.1155/2015/426069 · DOI
  35. Senf, 2008, Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy, FASEB J., 22, 3836, 10.1096/fj.08-110163 · DOI
  36. Lee, 2001, Targetedhsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice, Stroke, 32, 2905, 10.1161/hs1201.099604 · DOI
  37. Tsuchiya, 2003, Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia, J. Cereb. Blood Flow Metab., 23, 718, 10.1097/01.WCB.0000054756.97390.F7 · DOI
  38. Rajdev, 2000, Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction, Ann. Neurol., 47, 782, 10.1002/1531-8249(200006)47:6<782::AID-ANA11>3.0.CO;2-3 · DOI
  39. Yenari, 1999, The neuroprotective potential of heat shock protein 70 (HSP70), Mol. Med. Today, 5, 525, 10.1016/S1357-4310(99)01599-3 · DOI
  40. Hartl, 2002, Molecular chaperones in the cytosol: from nascent chain to folded protein, Science, 295, 1852, 10.1126/science.1068408 · DOI
  41. Yenari, 2005, Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection, Ann. N. Y. Acad. Sci., 1053, 74, 10.1196/annals.1344.007 · DOI
  42. Kim, 2015, Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation, Neuroscience, 286, 272, 10.1016/j.neuroscience.2014.11.057 · DOI
  43. Nishi, 1993, Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model, Brain Res., 615, 281, 10.1016/0006-8993(93)90039-P · DOI

Cited by

Sorted by citations

Metadata

Authors
Guo, D., Ma, J., Li, T., & Yan, L.
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2018-08
Volume
369
Issue
1
Pages
34-42
ISSN
0014-4827
DOI
10.1016/j.yexcr.2018.04.027
Cited by
54
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review