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Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3

Guo, Dong, Ma, Ji, Li, Tengfei, Yan, Lei·2018·Experimental Cell Research
DOI 10.1016/j.yexcr.2018.04.027
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Abstract

Dysfunction of the microRNA (miRNA) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells after oxygen-glucose deprivation (OGD) and mouse brain after transient middle cerebral artery occlusion (MCAO). OGD treatment significantly increased N2A cell death and Caspase-3 activity, and decreased Bcl-2 protein expression. In addition, MCAO treatment induced severe mouse brain infarction, mitochondrial reactive oxygen species (ROS) production, and long-term neurological deficit. Gain-of-miR-122 function significantly suppressed OGD- and MCAO-induced injures in vitro and in vivo. Subsequently, miR-122 was validated to directly bind to the predicted 3'-untranslated region (3'-UTR) of FOXO3 gene, and the inhibitory effects of miR-122 on ischemic injury in vitro and in vivo were overturned by FOXO3 overexpression. Moreover, our results further revealed that miR-122-FOXO3 axis functioned via the heat shock protein 70 (HSP-70)-mediated NF-κB pathway. Collectively, our data suggest that miR-122 inhibits ischemic neuronal death through the HSP-70-dependent NF-κB pathway by targeting FOXO3. These findings raise the possibility that this regulatory net may contribute to the pathogenesis of the ischemic brain i…

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Research works printed but not linked: 43

  1. Carelli, 2014, Mitochondrial DNA: impacting central and peripheral nervous systems, Neuron, 84, 1126, 10.1016/j.neuron.2014.11.022 · DOI
  2. George, 2015, Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments, Neuron, 87, 297, 10.1016/j.neuron.2015.05.041 · DOI
  3. Mattiasson, 2003, Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma, Nat. Med., 9, 1062, 10.1038/nm903 · DOI · Paper page
  4. Pei, 2014, DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death, J. Neurosci., 34, 6546, 10.1523/JNEUROSCI.5119-13.2014 · DOI
  5. Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res., 19, 92, 10.1101/gr.082701.108 · DOI · Paper page
  6. Pal, 2017, Animal models to study MicroRNA function, Adv. Cancer Res., 135, 53, 10.1016/bs.acr.2017.06.006 · DOI
  7. Yin, 2010, miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia, Neurobiol. Dis., 38, 17, 10.1016/j.nbd.2009.12.021 · DOI
  8. Khanna, 2013, Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size, J. Cereb. Blood Flow Metab., 33, 1197, 10.1038/jcbfm.2013.68 · DOI
  9. Huang, 2015, miR-134 regulates ischemia/reperfusion injury-induced neuronal cell death by regulating CREB signaling, J. Mol. Neurosci., 55, 821, 10.1007/s12031-014-0434-0 · DOI
  10. Sun, 2013, MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke, CNS Neurosci. Ther., 19, 813, 10.1111/cns.12142 · DOI
  11. Wang, 2014, MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression, Tumour Biol., 35, 8565, 10.1007/s13277-014-2089-4 · DOI
  12. Jickling, 2014, microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets, PLoS One, 9, e99283, 10.1371/journal.pone.0099283 · DOI
  13. Yang, 1997, Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury, Brain Res., 751, 181, 10.1016/S0006-8993(96)01277-2 · DOI
  14. Ouyang, 2012, miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo, Neurobiol. Dis., 45, 555, 10.1016/j.nbd.2011.09.012 · DOI
  15. Metz, 2002, Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination, J. Neurosci. Methods, 115, 169, 10.1016/S0165-0270(02)00012-2 · DOI
  16. Tatlisumak, 1996, Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging, Stroke, 27, 2292, 10.1161/01.STR.27.12.2292 · DOI
  17. Cui, 2014, Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats, J. Surg. Res., 192, 564, 10.1016/j.jss.2014.05.060 · DOI
  18. Ye, 2011, Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice, Neuropharmacology, 61, 815, 10.1016/j.neuropharm.2011.05.029 · DOI
  19. Kim, 2005, Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression, FASEB J., 19, 1042, 10.1096/fj.04-2841fje · DOI
  20. Coulouarn, 2009, Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties, Oncogene, 28, 3526, 10.1038/onc.2009.211 · DOI
  21. Fornari, 2009, MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells, Cancer Res., 69, 5761, 10.1158/0008-5472.CAN-08-4797 · DOI
  22. Chen, 2013, miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease, Biochem. Biophys. Res. Commun., 438, 133, 10.1016/j.bbrc.2013.07.040 · DOI
  23. Wang, 2012, MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R, PLoS One, 7, e47053, 10.1371/journal.pone.0047053 · DOI
  24. Manfè, 2012, miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma, PLoS One, 7, e29541, 10.1371/journal.pone.0029541 · DOI
  25. Liu d, 2016, Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats, J. Cereb. Blood Flow Metab., 36, 1374, 10.1177/0271678X15610786 · DOI
  26. Mattson, 2001, NF-kappaB in neuronal plasticity and neurodegenerative disorders, J. Clin. Investig., 107, 247, 10.1172/JCI11916 · DOI · Paper page
  27. Lawrence, 2009, The nuclear factor NF-kappaB pathway in inflammation, Cold Spring Harb. Perspect. Biol., 1, a001651, 10.1101/cshperspect.a001651 · DOI
  28. Smith, 2012, Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases, Brain Res Bull., 87, 10, 10.1016/j.brainresbull.2011.10.004 · DOI · Paper page
  29. Mattson, 2006, Roles for NF-kappaB in nerve cell survival, plasticity, and disease, Cell Death Differ., 13, 852, 10.1038/sj.cdd.4401837 · DOI
  30. Mattson, 2005, NF-kappaB in the survival and plasticity of neurons, Neurochem. Res., 30, 883, 10.1007/s11064-005-6961-x · DOI
  31. Tao, 2013, Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3, J. Biol. Chem., 288, 17214, 10.1074/jbc.M112.445965 · DOI
  32. Cho, 2015, Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism, Oncotarget, 6, 43, 10.18632/oncotarget.2723 · DOI
  33. Samuel, 2008, Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity, J. Agric. Food Chem., 56, 9692, 10.1021/jf802050h · DOI
  34. Song, 2015, Glutathione suppresses cerebral infarct volume and cell death after ischemic injury: involvement of FOXO3 inactivation and Bcl2 expression, Oxid. Med. Cell Longev., 2015, 426069, 10.1155/2015/426069 · DOI
  35. Senf, 2008, Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy, FASEB J., 22, 3836, 10.1096/fj.08-110163 · DOI
  36. Lee, 2001, Targetedhsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice, Stroke, 32, 2905, 10.1161/hs1201.099604 · DOI
  37. Tsuchiya, 2003, Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia, J. Cereb. Blood Flow Metab., 23, 718, 10.1097/01.WCB.0000054756.97390.F7 · DOI
  38. Rajdev, 2000, Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction, Ann. Neurol., 47, 782, 10.1002/1531-8249(200006)47:6<782::AID-ANA11>3.0.CO;2-3 · DOI
  39. Yenari, 1999, The neuroprotective potential of heat shock protein 70 (HSP70), Mol. Med. Today, 5, 525, 10.1016/S1357-4310(99)01599-3 · DOI
  40. Hartl, 2002, Molecular chaperones in the cytosol: from nascent chain to folded protein, Science, 295, 1852, 10.1126/science.1068408 · DOI
  41. Yenari, 2005, Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection, Ann. N. Y. Acad. Sci., 1053, 74, 10.1196/annals.1344.007 · DOI
  42. Kim, 2015, Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation, Neuroscience, 286, 272, 10.1016/j.neuroscience.2014.11.057 · DOI
  43. Nishi, 1993, Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model, Brain Res., 615, 281, 10.1016/0006-8993(93)90039-P · DOI

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Metadata

Authors
Guo, D., Ma, J., Li, T., & Yan, L.
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2018-08
Volume
369
Issue
1
Pages
34-42
ISSN
0014-4827
DOI
10.1016/j.yexcr.2018.04.027
Cited by
54
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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