Back to the metal age: battle for metals at the host–pathogen interface during urinary tract infection

Subashchandrabose, Sargurunathan; Mobley, Harry L. T.

doi:10.1039/c4mt00329b

Cited by 80Escherichia coli research studiesBacterial Genetics and BiotechnologyUrinary Tract Infections Management

Back to the metal age: battle for metals at the host–pathogen interface during urinary tract infection

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Subashchandrabose, Sargurunathan, Mobley, Harry L. T.·2015·Metallomics

DOI 10.1039/c4mt00329bPMC PMC4634365

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Abstract

Urinary tract infection (UTI) represents one of the most common bacterial infections in humans and uropathogenic E. coli (UPEC) is the major causative agent of UTI in people. Research on UPEC and other bacterial pathogens causing UTI has now identified the critical role of metal transport systems in the pathogenesis of UTI. Here we review the major effectors of metal transport in bacteria and host proteins that impair metal acquisition by bacterial pathogens. In particular, we describe the studies that identified iron, zinc and nickel import and copper export as key virulence and fitness determinants during UTI. Various metal transport systems and mechanisms that govern the expression of metal transport systems are also presented here. Specific examples from UPEC and other uropathogens, when available, are presented to depict the battle for metals at the host-pathogen interface during UTI.

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Genes for acquiring iron are recognized virulence factors; their loss reduces pathogenicity without killing the organism.
“Iron acquisition genes are now established as microbial virulence factors, in the sense that loss of these genes impairs pathogenicity without completely compromising organism viability 3, 86.”
From Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy (2015) · cites this paper as [86]

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Authors: Subashchandrabose, S., & Mobley, H. L. T.
Affiliations: University of Michigan (US)
Corresponding author: Mobley, Harry L. T.
ORCID: Subashchandrabose, Sargurunathan
Mobley, Harry L. T.
Venue: Metallomics
Publisher: Oxford University Press (OUP)
Published: 2015
Volume: 7
Issue: 6
Pages: 935-942
ISSN: 1756-5901 (ISSN-L)
1756-591X
DOI: 10.1039/c4mt00329b
PMC: PMC4634365
OpenAlex: W2098256708
Cited by: 80
References: 64
Citations by year: 2026: 3 · 2025: 6 · 2024: 11 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 12 · 2015: 4
FWCI: 1.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Metallomics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK094777)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
Keywords: urinary tract infection, uropathogenic Escherichia coli, host-pathogen interaction, iron acquisition, copper exports, bacterial virulence, metal homeostasis, uropathogens
MeSH terms: Animals, Bacteria, Biological Transport, Humans, Metals, Urinary Tract Infections, Host-Pathogen Interactions, Metabolomics

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

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Back to the metal age: battle for metals at the host–pathogen interface during urinary tract infection

Abstract

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Claims the paper makes

Claims other papers make about this one

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Cites

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