CoChat
Sign Up
Cited by 1,586Stress Responses and CortisolRegulation of Appetite and ObesityAdrenal Hormones and Disorders

The DOI matches its Crossref record; 335 of the 335 references it cites were found in a registry or an index.

Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness

Herman, James P., Figueiredo, Helmer, Mueller, Nancy K., Ulrich-Lai, Yvonne, Ostrander, Michelle M., Choi, Dennis C., Cullinan, William E.·2003·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2003.07.001
Open this paper in CoChat — free account

Abstract

Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival. The following review documents the principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate excitatory and inhibitory inputs into a net secretory signal at the pituitary gland. Regions that directly innervate these neurons are primed to relay sensory information, including visceral afferents, nociceptors and circumventricular organs, thereby promoting 'reactive' corticosteroid responses to emergent homeostatic challenges. Indirect inputs from the limbic-associated structures are capable of activating these same cells in the absence of frank physiological challenges; such 'anticipatory' signals regulate glucocorticoid release under conditions in which physical challenges may be predicted, either by innate programs or conditioned stimuli. Importantly, 'anticipatory' circuits are integrated with neural pathways subserving 'reactive' responses at multiple levels. The resultant hierarchical organization of stress-responsive neurocircuitries is capable of comparing information from multiple limbic sources with internally generated and peripherally sensed information, thereby tuning the relative activity of the adrenal cortex. Imbalances among these limbic pathways and homeostatic sensors are likely to underlie hypothalamo-pituitary-adrenocortical dysfunction associated with numerous disease processes.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.yfrne.2003.07.001

Cites

335 of 335 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 335 references

Research works printed but not linked: 1

  1. Cullinan, 1998, Evidence for a PVN site of action of GABA in the regulatory control of the rat stress axis, The Physiologist, 41, 353

Cited by

Sorted by citations

See all 1,586

Related

Metadata

Authors
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E.
Affiliations
  • University of Cincinnati (US)
  • Marquette University (US)
Corresponding author
Herman, James P.
ORCID
Herman, James P.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2003-07
Volume
24
Issue
3
Pages
151-180
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2003.07.001
OpenAlex
W1979295154
Cited by
1,586
References
335
Citations by year
2026: 23 · 2025: 31 · 2024: 38 · 2023: 47 · 2022: 67 · 2021: 68 · 2020: 66 · 2019: 68 · 2018: 73 · 2017: 89 · 2016: 96 · 2015: 72 · 2014: 86 · 2013: 100 · 2012: 89
FWCI
19.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f32mh065770-02, 5r29mh056577-05, 5r03mh060819-03)
  • National Institute of Mental Health (MH 60819, MH49698, MH56577, MH65770)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypothalamic-pituitary-adrenal axis, stress response, corticotropin-releasing hormone neurons, paraventricular nucleus, stress integration, anticipatory stress, limbic system, visceral afferents, nociceptors, circumventricular organs, adrenal cortex, neurocircuitry, homeostatic regulation
MeSH terms
Adrenocorticotropic Hormone, Amygdala, Animals, Corticotropin-Releasing Hormone, Glucocorticoids, Hippocampus, Humans, Hypothalamo-Hypophyseal System, Hypothalamus, Limbic System, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Raphe Nuclei, Septal Nuclei, Stress, Physiological, Thalamus, Prefrontal Cortex, Solitary Nucleus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review