The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Corticosteroid hormones in the central stress response: Quick-and-slow
Abstract
Recent evidence shows that corticosteroid hormones exert rapid non-genomic effects on neurons in the hypothalamus and the hippocampal CA1 region. The latter depend on classical mineralocorticoid receptors which are accessible from the outside of the plasma membrane and display a 10-fold lower affinity for corticosterone than the nuclear version involved in neuroprotection. Consequently, this 'membrane' receptor could play an important role while corticosteroid levels are high, i.e. during the initial phase of the stress response. We propose that during this phase corticosterone promotes hippocampal excitability and amplifies the effect of other stress hormones. These permissive non-genomic effects may contribute to fast behavioral effects and encoding of stress-related information. The fast effects are complemented by slower glucocorticoid receptor-mediated effects which facilitate suppression of temporary raised excitability, recovery from the stressful experience and storage of information for future use.
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“Forebrain GR activation inhibits HPA activity through tonic negative-feedback inhibition.123,124”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [123]
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Cites
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“In concert with other stress mediators, the stress-induced rise in glucocorticoid concentration facilitates adaptation to stress and restores homeostasis, (among other things) by enhancing emotional arousal and promoting motivational and cognitive processes [6,17,26].”
BackgroundStress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Self-citationStress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · cited 1×
“Moreover, corticosteroid effects were observed on cognitive operations in appraisal of novel situations [29,30], extinction processes [2] and more recently on retrieval processes [7,35].”
BackgroundLearning under stress: how does it work?
Joëls, M., Pu, Z., Wiegert, O., Oitzl, M. S., & Krugers, H. J. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.02.002 · Cited by 947
Self-citationStress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
Roozendaal, B. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4080 · Cited by 838
Di, S., Malcher‐Lopes, R., Halmos, K. C., & Tasker, J. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04850.2003 · Cited by 820
Role of adrenal stress hormones in forming lasting memories in the brain
McGaugh, J. L., & Roozendaal, B. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00306-9 · Cited by 818
Karst, H., Berger, S., Turiault, M., Tronche, F., Schütz, G., & Joëls, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507572102 · Cited by 774
Self-citationDiamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · cited 1×
“It will therefore be very important to also examine rapid effects in other limbic areas important for the central stress response, like amygdalar nuclei or subareas of the prefrontal cortex [10,19,25].”
BackgroundSelective corticosteroid antagonists modulate specific aspects of spatial orientation learning.
Oitzl, M. S., & de Kloet, E. R. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.62 · Cited by 649
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Stress revisited: a critical evaluation of the stress concept
Koolhaas, J. M., Bartolomucci, A., Buwalda, B., de Boer, S. F., Flügge, G., Korte, S. M., Meerlo, P., Murison, R., Olivier, B., Palanza, P., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.003 · Cited by 1,626
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action
Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887
Glucocorticoids, prenatal stress and the programming of disease
Harris, A., & Seckl, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.007 · Cited by 871
Metadata
- Authors
- de Kloet, E. R., Karst, H., & Joëls, M.
- Affiliations
- Leiden University Medical Center (NL)
- University of Amsterdam (NL)
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 29
- Issue
- 2
- Pages
- 268-272
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2137942121
- Cited by
- 391
- References
- 43
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 17 · 2021: 16 · 2020: 21 · 2019: 14 · 2018: 25 · 2017: 17 · 2016: 27 · 2015: 23 · 2014: 38 · 2013: 22 · 2012: 31
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- corticosteroids, non-genomic steroid effects, glucocorticoid receptor, hypothalamus, hippocampal CA1, hippocampal excitability, stress response, corticosterone, neuroprotection
- MeSH terms
- Adrenal Cortex Hormones, Animals, Hippocampus, Humans, Hypothalamus, Neurons, Receptors, Glucocorticoid, Stress, Physiological, Time Factors, Genome, Receptors, Mineralocorticoid
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