The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
An energetic view of stress: Focus on mitochondria
Open accessAbstract
Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is largely derived from mitochondria - unique multifunctional organelles with their own genome. Four main elements connect mitochondria to stress: (1) Energy is required at the molecular, (epi)genetic, cellular, organellar, and systemic levels to sustain components of stress responses; (2) Glucocorticoids and other steroid hormones are produced and metabolized by mitochondria; (3) Reciprocally, mitochondria respond to neuroendocrine and metabolic stress mediators; and (4) Experimentally manipulating mitochondrial functions alters physiological and behavioral responses to psychological stress. Thus, mitochondria are endocrine organelles that provide both the energy and signals that enable and direct stress adaptation. Neural circuits regulating social behavior - as well as psychopathological processes - are also influenced by mitochondrial energetics. An integrative view of stress as an energy-driven process opens new opportunities to study mechanisms of adaptation and regulation across the lifespan.
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Cited by
Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner, V., Picard, M., & Hajnóczky, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0133-0 · Cited by 622
Self-citationOxidative eustress: On constant alert for redox homeostasis
Sies, H. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101867 · Cited by 331
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Estrogenic control of mitochondrial function
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Acute psychological stress increases serum circulating cell-free mitochondrial DNA
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Metadata
- Authors
- Picard, M., McEwen, B. S., Epel, E. S., & Sandi, C.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 49
- Pages
- 72-85
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2783495389
- Cited by
- 542
- References
- 163
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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