Allostatic load biomarkers of chronic stress and impact on health and cognition
Abstract
The allostatic load model expands the stress-disease literature by proposing a temporal cascade of multi-systemic physiological dysregulations that contribute to disease trajectories. By incorporating an allostatic load index representing neuroendocrine, immune, metabolic, and cardiovascular system functioning, numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods employed in biomedical practice. This article reviews theoretical and empirical work using the allostatic load model vis-à-vis the effects of chronic stress on physical and mental health. Specific risk and protective factors associated with increased allostatic load are elucidated and policies for promoting successful aging are proposed.
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Even in the context of adaptive functioning, the cumulative allostatic load associated with chronically harsh environments can exhaust adaptive resources and present significant, long-term consequences to health and well-being, with much individual variation as a function of personal attributes and environmental supports.
“At the same time, even in the context of adaptive functioning, the cumulative allostatic load associated with chronically harsh environments can exhaust adaptive resources and present significant, long-term consequences to health and well-being, with much individual variation as a function of personal attributes and environmental supports (e.g., Juster, McEwen, & Lupien, 2010;McEwen, 1998;Miller,”
From Malleability, plasticity, and individuality: How children learn and develop in context<sup>1</sup> (2019) · cites this paper as Juster, McEwen, & Lupien, 2010
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The biological impacts of Indigenous residential school attendance on the next generation
Chief Moon-Riley, K., Copeland, J. L., Metz, G. A. S., & Currie, C. L. (2019) · SSM - Population Health · doi:10.1016/j.ssmph.2018.100343 · Cited by 34 · see citing works
Polacchini, A., Girardi, D., Falco, A., Zanotta, N., Comar, M., De Carlo, N. A., & Tongiorgi, E. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.02.002 · Cited by 30 · see citing works
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Allostatic load and executive functions in overweight adults
Ottino-González, J., Jurado, M. A., García-García, I., Caldú, X., Prats-Soteras, X., Tor, E., Sender-Palacios, M. J., & Garolera, M. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.009 · Cited by 31 · see citing works
A Landscape of Subjective and Objective Stress in African-American Dementia Family Caregivers
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The Need for a Transdisciplinary, Global Health Framework
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An Introduction to Trauma and Health
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A clinician and service user's perspective on managing ms: pleasure, purpose, practice
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- Authors
- Juster, R.-P., McEwen, B. S., & Lupien, S. J.
- Affiliations
- Université de Montréal (CA)
- Rockefeller University (US)
- Corresponding author
- Juster, Robert-Paul
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 35
- Issue
- 1
- Pages
- 2-16
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1963629744
- Cited by
- 2,565
- References
- 20
- Citations by year
- 2026: 214 · 2025: 190 · 2024: 167 · 2023: 176 · 2022: 186 · 2021: 199 · 2020: 237 · 2019: 210 · 2018: 171 · 2017: 139 · 2016: 163 · 2015: 138 · 2014: 118 · 2013: 86 · 2012: 94
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
- Keywords
- allostatic load, chronic stress, allostatic load index, biomarkers, neuroendocrine dysfunction, immune dysregulation, metabolic dysfunction, cardiovascular dysregulation, stress and disease, cognitive function, physical health, mental health, risk factors, protective factors, successful aging, aging policy
- MeSH terms
- Adolescent, Adult, Aged, Aging, Child, Cognition, Female, Health Status, Humans, Male, Middle Aged, Stress, Psychological, Biomarkers, Allostasis
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