The role of G protein-coupled estrogen receptor 1 on neurological disorders

Cloning of a novel receptor expressed in rat prostate and ovary.

Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,792 · see citing works

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302 · see citing works

Multiple sclerosis

Thompson, A. J., Baranzini, S. E., Geurts, J. J. G., Hemmer, B., & Ciccarelli, O. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30481-1 · Cited by 1,856 · see citing works

Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells

Thomas, P., Pang, Y., Filardo, E. J., & Dong, J. (2004) · Endocrinology · doi:10.1210/en.2004-1064 · Cited by 1,410 · see citing works

Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

Filardo, E. J., Quinn, J. A., Bland, K. I., & Frackelton, A. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0532 · Cited by 1,387 · see citing works

Prevalence and incidence studies of anxiety disorders: A systematic review of the literature

Somers, J. M., Goldner, E. M., Waraich, P., & Hsu, L. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100206 · Cited by 1,114 · see citing works

Therapeutic interventions after spinal cord injury

Thuret, S., Moon, L. D. F., & Gage, F. H. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1955 · Cited by 1,012 · see citing works

Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects

Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 986 · see citing works

Estrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female Rat

Tanapat, P., Hastings, N. B., Reeves, A. J., & Gould, E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05792.1999 · Cited by 978 · see citing works

The G-protein-coupled estrogen receptor GPER in health and disease

Prossnitz, E. R., & Barton, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.122 · Cited by 925 · see citing works

Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

Filardo, E. J., Quinn, J. A., Frackelton, A. R., & Bland, K. I. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.1.0758 · Cited by 907 · see citing works

Virtual and biomolecular screening converge on a selective agonist for GPR30

Bologa, C., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., Parker, M. A., Tkachenko, S. E., Savchuk, N., Sklar, L. A., et al. (2006) · Nature Chemical Biology · doi:10.1038/nchembio775 · Cited by 819 · see citing works

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Brann, D. W., Dhandapani, K. M., Wakade, C. G., Mahesh, V. B., & Khan, M. M. (2007) · Steroids · doi:10.1016/j.steroids.2007.02.003 · Cited by 649 · see citing works

Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption

Thomas, P., & Dong, J. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.017 · Cited by 604 · see citing works

Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30

Prossnitz, E. R., Arterburn, J. B., Smith, H. O., Oprea, T. I., Sklar, L. A., & Hathaway, H. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100518 · Cited by 590 · see citing works

In vivo effects of a GPR30 antagonist

Dennis, M. K., Burai, R., Ramesh, C., Petrie, W. K., Alcon, S. N., Nayak, T. K., Bologa, C., Leitão, A., Brailoiu, E., Deliu, E., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.168 · Cited by 533 · see citing works

Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system

Brailoiu, E., Dun, S. L., Brailoiu, G. C., Mizuo, K., Sklar, L. A., Oprea, T. I., Prossnitz, E. R., & Dun, N. J. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0017 · Cited by 501 · see citing works

REGULATION OF SIGNAL TRANSDUCTION PATHWAYS BY ESTROGEN AND PROGESTERONE

Edwards, D. P. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120151 · Cited by 499 · see citing works

Estrogen receptor interaction with co-activators and co-repressors☆

Klinge, C. M. (2000) · Steroids · doi:10.1016/s0039-128x(99)00107-5 · Cited by 489 · see citing works

Activation of the Novel Estrogen Receptor G Protein-Coupled Receptor 30 (GPR30) at the Plasma Membrane

Filardo, E. J., Quinn, J. A., Pang, Y., Graeber, C. T., Shaw, S. K., Dong, J., & Thomas, P. (2007) · Endocrinology · doi:10.1210/en.2006-1605 · Cited by 450 · see citing works

Estrogen biology: New insights into GPER function and clinical opportunities

Prossnitz, E. R., & Barton, M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.02.002 · Cited by 404 · see citing works

Estradiol Activates Group I and II Metabotropic Glutamate Receptor Signaling, Leading to Opposing Influences on cAMP Response Element-Binding Protein

Boulware, M. I., Weick, J. P., Becklund, B. R., Kuo, S. P., Groth, R. D., & Mermelstein, P. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1427-05.2005 · Cited by 379 · see citing works

Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology

Filardo, E. J., & Thomas, P. (2012) · Endocrinology · doi:10.1210/en.2012-1061 · Cited by 366 · see citing works

Plasma membrane estrogen receptors

Levin, E. R. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.06.009 · Cited by 365 · see citing works

Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues

Hazell, G. G. J., Yao, S. T., Roper, J. A., Prossnitz, E. R., O’Carroll, A., & Lolait, S. J. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0066 · Cited by 358 · see citing works

G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane

Funakoshi, T., Yanai, A., Shinoda, K., Kawano, M. M., & Mizukami, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.191 · Cited by 352 · see citing works

Discovery of Three Novel G-Protein-Coupled Receptor Genes

O’Dowd, B. F., Nguyen, T., Marchese, A., Cheng, R., Lynch, K. R., Heng, H. H., Kolakowski, L. F., & George, S. R. (1998) · Genomics · doi:10.1006/geno.1998.5095 · Cited by 335 · see citing works

Estrogen and Cancer

Liang, J., & Shang, Y. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183708 · Cited by 319 · see citing works

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity

Dennis, M. K., Field, A. S., Burai, R., Ramesh, C., Petrie, W. K., Bologa, C., Oprea, T. I., Yamaguchi, Y., Hayashi, S., Sklar, L. A., et al. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.07.002 · Cited by 312 · see citing works

Estrogen Receptor Target Gene: An Evolving Concept

Carroll, J. S., & Brown, M. A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0334 · Cited by 284 · see citing works

GPR30 Does Not Mediate Estrogenic Responses in Reproductive Organs in Mice

Otto, C., Fuchs, I., Kauselmann, G., Kern, H., Zevnik, B., Andreasen, P., Schwarz, G., Altmann, H., Klewer, M., Schoor, M., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.071175 · Cited by 278 · see citing works

Oestrogen receptor knockout mice: roles for oestrogen receptors α and β in reproductive tissues

Hewitt, S. C., & Korach, K. S. (2003) · Reproduction · doi:10.1530/rep.0.1250143 · Cited by 261 · see citing works

Cognitive and neurological impairment in mood disorders

Marvel, C. L., & Paradiso, S. (2004) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(03)00106-0 · Cited by 256 · see citing works

G Protein-Coupled Receptor 30 Localizes to the Endoplasmic Reticulum and Is Not Activated by Estradiol

Otto, C., Rohde-Schulz, B., Schwarz, G., Fuchs, I., Klewer, M., Brittain, D. E. A., Langer, G., Bader, B., Prelle, K., Nubbemeyer, R., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0269 · Cited by 254 · see citing works

Cloning of Human cDNA Encoding a Novel Heptahelix Receptor Expressed in Burkitt's Lymphoma and Widely Distributed in Brain and Peripheral Tissues

Owman, C., Blay, P., Nilsson, C., & Lolait, S. J. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1654 · Cited by 224 · see citing works

Neuroprotective effects of estrogens following ischemic stroke

Suzuki, S., Brown, C. M., & Wise, P. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.007 · Cited by 223 · see citing works

Estrogen Receptor (ER)α and ERβ Exhibit Unique Pharmacologic Properties When Coupled to Activation of the Mitogen-Activated Protein Kinase Pathway*

Wade, C. B., Robinson, S., Shapiro, R. A., & Dorsa, D. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8071 · Cited by 213 · see citing works

Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation

Zhao, Z., Fan, L., & Frick, K. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910578107 · Cited by 205 · see citing works

Cellular and subcellular localization of estrogen and progestin receptor immunoreactivities in the mouse hippocampus

Mitterling, K. L., Spencer-Segal, J. L., Dziedzic, N., Shenoy, S. A., McCarthy, K. J., Waters, E. M., McEwen, B. S., & Milner, T. A. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22361 · Cited by 203 · see citing works

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodentsPreprint

Frick, K. M., Kim, J., Tuscher, J. J., & Fortress, A. M. (2015) · Learning & Memory · doi:10.1101/lm.037267.114 · Cited by 202 · see citing works

Direct and Indirect Regulation of Gonadotropin-Releasing Hormone Neurons by Estradiol1

Petersen, S. L., Ottem, E. N., & Carpenter, C. D. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.019745 · Cited by 201 · see citing works

The Memory-Enhancing Effects of Hippocampal Estrogen Receptor Activation Involve Metabotropic Glutamate Receptor Signaling

Boulware, M. I., Heisler, J. D., & Frick, K. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1716-13.2013 · Cited by 196 · see citing works

Expression Pattern of G Protein-Coupled Receptor 30 in LacZ Reporter Mice

Isensee, J., Meoli, L., Zazzu, V., Nabzdyk, C. S., Witt, H., Soewarto, D., Effertz, K., Fuchs, H., Gailus‐Durner, V., Busch, D. H., et al. (2008) · Endocrinology · doi:10.1210/en.2008-1488 · Cited by 189 · see citing works

Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis

Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks‐Miller, M., Mahmoudi, M., Dennis, M. K., Prossnitz, E. R., Karpus, W. J., & Horuk, R. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.023 · Cited by 181 · see citing works

G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth

Petrie, W. K., Dennis, M. K., Hu, C., Dai, D. D., Arterburn, J. B., Smith, H. O., Hathaway, H. J., & Prossnitz, E. R. (2013) · Obstetrics and Gynecology International · doi:10.1155/2013/472720 · Cited by 166 · see citing works

17β-Estradiol Inhibits Oxidative Stress-Induced Apoptosis in Keratinocytes by Promoting Bcl-2 Expression

Kanda, N., & Watanabe, S. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12617.x · Cited by 166 · see citing works

Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER

Prossnitz, E. R., & Barton, M. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.05.001 · Cited by 159 · see citing works

17β-Estradiol Stimulates the Growth of Human Keratinocytes by Inducing Cyclin D2 Expression

Kanda, N., & Watanabe, S. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.12645.x · Cited by 159 · see citing works

The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function

Meyer, M. R., Prossnitz, E. R., & Barton, M. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.06.003 · Cited by 153 · see citing works

Involvement of G Protein-Coupled Receptor 30 (GPR30) in Rapid Action of Estrogen in Primate LHRH Neurons

Noel, S. D., Keen, K. L., Baumann, D. I., Filardo, E. J., & Terasawa, E. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0299 · Cited by 152 · see citing works

Synthetic Estrogen Derivatives Demonstrate the Functionality of Intracellular GPR30

Revankar, C. M., Mitchell, H. D., Field, A. S., Burai, R., Corona, C. R., Ramesh, C., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2007) · ACS Chemical Biology · doi:10.1021/cb700072n · Cited by 150 · see citing works

Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1

Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Proctor, T., Vandenbark, A. A., & Offner, H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803205 · Cited by 148 · see citing works

Acute Administration of Non-Classical Estrogen Receptor Agonists Attenuates Ischemia-Induced Hippocampal Neuron Loss in Middle-Aged Female Rats

Lebesgue, D., Traub, M., Butte-Smith, M. D., Chen, C. H., Zukin, R. S., Kelly, M. J., & Etgen, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008642 · Cited by 146 · see citing works

Estrogens and Experimental Ischemic Stroke: A Systematic Review

Gibson, C. L., Gray, L. J., Murphy, S. P., & Bath, P. M. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600270 · Cited by 142 · see citing works

Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampusPreprint

Fortress, A. M., Fan, L., Orr, P. T., Zhao, Z., & Frick, K. M. (2013) · Learning & Memory · doi:10.1101/lm.026732.112 · Cited by 141 · see citing works

Post-synaptic Density-95 (PSD-95) Binding Capacity of G-protein-coupled Receptor 30 (GPR30), an Estrogen Receptor That Can Be Identified in Hippocampal Dendritic Spines

Akama, K. T., Thompson, L. I., Milner, T. A., & McEwen, B. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.412478 · Cited by 140 · see citing works

Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens

Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005272 · Cited by 138 · see citing works

THE BINDING OF ESTRADIOL IN THE UTERUS: A MECHANISM FOR DEREPRESSION OF RNA SYNTHESIS

Talwar, G. P., Segal, S. J., Evans, A., & Davidson, O. W. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.4.1059 · Cited by 137 · see citing works

Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke

Li, J., Siegel, M., Yuan, M., Zeng, Z., Finnucan, L., Persky, R., Hurn, P. D., & McCullough, L. D. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.181 · Cited by 136 · see citing works

Alzheimer's Disease: Diagnosis and Treatment Across the Spectrum of Disease Severity

Neugroschl, J. A., & Wang, S. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20279 · Cited by 132 · see citing works

17β-Estradiol and Agonism of G-protein-Coupled Estrogen Receptor Enhance Hippocampal Memory via Different Cell-Signaling Mechanisms

Kim, J., Szinte, J. S., Boulware, M. I., & Frick, K. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0257-15.2016 · Cited by 129 · see citing works

Estradiol and G1 Reduce Infarct Size and Improve Immunosuppression after Experimental Stroke

Zhang, B., Subramanian, S., Dziennis, S., Jia, J., Uchida, M., Akiyoshi, K., Migliati, E., Lewis, A. D., Vandenbark, A. A., Offner, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902339 · Cited by 127 · see citing works

Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation

Matsuda, K.-I., Sakamoto, H., Mori, H., Hosokawa, K., Kawamura, A., Itose, M., Nishi, M., Prossnitz, E. R., & Kawata, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.108 · Cited by 120 · see citing works

Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats

Hammond, R., Mauk, R., Ninaci, D., Nelson, D., & Gibbs, R. B. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.06.008 · Cited by 119 · see citing works

The G Protein-coupled Receptor 30 Is Up-regulated by Hypoxia-inducible Factor-1α (HIF-1α) in Breast Cancer Cells and Cardiomyocytes

Recchia, A. G., Francesco, E. M. D., Vivacqua, A., Sisci, D., Panno, M. L., Andò, S., & Maggiolini, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172247 · Cited by 116 · see citing works

Estrogen Receptors Are Found in Glia and at Extranuclear Neuronal Sites in the Dorsal Striatum of Female Rats: Evidence for Cholinergic But Not Dopaminergic Colocalization

Almey, A., Filardo, E. J., Milner, T. A., & Brake, W. G. (2012) · Endocrinology · doi:10.1210/en.2012-1458 · Cited by 116 · see citing works

Differential effects of estrogen on hippocampal- and striatal-dependent learning

Davis, D. M., Jacobson, T. K., Aliakbari, S., & Mizumori, S. J. Y. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.06.004 · Cited by 113 · see citing works

Estradiol protects dopaminergic neurons in a MPP+Parkinson’s disease model

Sawada, H., Ibi, M., Kihara, T., Honda, K., Nakamizo, T., Kanki, R., Nakanishi, M., Sakka, N., Akaike, A., & Shimohama, S. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00049-7 · Cited by 113 · see citing works

Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress

Tian, Z., Wang, Y., Zhang, N., Guo, Y., Feng, B., Liu, S., & Zhao, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.011 · Cited by 110 · see citing works

GPR30 mediates estrogen rapid signaling and neuroprotection

Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. B., Yang, F., Brann, D. W., & Wang, R. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.024 · Cited by 110 · see citing works

GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer

Feldman, R. D., & Limbird, L. E. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104651 · Cited by 109 · see citing works

GPER1/GPR30 in the brain: Crosstalk with classical estrogen receptors and implications for behavior

Hadjimarkou, M. M., & Vasudevan, N. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.04.012 · Cited by 108 · see citing works

Rapid effects of the G-protein coupled oestrogen receptor (GPER) on learning and dorsal hippocampus dendritic spines in female mice

Gabor, C., Lymer, J., Phan, A., & Choleris, E. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.017 · Cited by 108 · see citing works

Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30

Ding, Q., Gros, R., Limbird, L. E., Chorazyczewski, J., & Feldman, R. D. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00185.2009 · Cited by 107 · see citing works

GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus

Hammond, R., Nelson, D. A., & Gibbs, R. B. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.007 · Cited by 107 · see citing works

A novel putative G‐protein‐coupled receptor expressed in lung, heart and lymphoid tissue

Kvingedal, A. M., & Smeland, E. B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00278-0 · Cited by 106 · see citing works

GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance

Hammond, R., & Gibbs, R. B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.098 · Cited by 104 · see citing works

Cloning of a Novel Member of the G Protein-Coupled Receptor Family Related to Peptide Receptors

Feng, Y., & Gregor, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6161 · Cited by 102 · see citing works

Sex-Dependent Effects of G Protein–Coupled Estrogen Receptor Activity on Outcome After Ischemic Stroke

Broughton, B. R. S., Brait, V. H., Kim, H. A., Lee, S., Chu, H. X., Gardiner-Mann, C. V., Guida, E., Evans, M. A., Miller, A. A., Arumugam, T. V., et al. (2014) · Stroke · doi:10.1161/strokeaha.113.001499 · Cited by 100 · see citing works

Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus

Xu, H. E., Qin, S., Carrasco, G. A., Dai, Y., Filardo, E. J., Prossnitz, E. R., Battaglia, G., DonCarlos, L. L., & Muma, N. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.028 · Cited by 98 · see citing works

Mechanisms of gender-linked ischemic brain injury

Liu, M., Dziennis, S., Hurn, P. D., & Alkayed, N. J. (2009) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2009-0467 · Cited by 95 · see citing works

G Protein-Coupled Receptor 30 Expression Is Required for Estrogen Stimulation of Primordial Follicle Formation in the Hamster Ovary

Wang, C., Prossnitz, E. R., & Roy, S. K. (2008) · Endocrinology · doi:10.1210/en.2008-0441 · Cited by 93 · see citing works

Dehydroepiandrosterone (DHEA) such as 17β‐estradiol prevents MPTP‐induced dopamine depletion in mice

D’Astous, M., Morissette, M., Tanguay, B., Callier, S., & Paolo, T. D. (2002) · Synapse · doi:10.1002/syn.10145 · Cited by 93 · see citing works

GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice

Anchan, M., Clark, S. M., Pollard, K. J., & Vasudevan, N. (2013) · Brain and Behavior · doi:10.1002/brb3.197 · Cited by 92 · see citing works

Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia

Dun, S. L., Brailoiu, G. C., Gao, X. Y., Brailoiu, E., Arterburn, J. B., Prossnitz, E. R., Oprea, T. I., & Dun, N. J. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21980 · Cited by 91 · see citing works

17 β -Estradiol Confers Protection after Traumatic Brain Injury in the Rat and Involves Activation of G Protein-Coupled Estrogen Receptor 1

Day, N. L., Floyd, C. L., D'Alessandro, T. L., Hubbard, W. J., & Chaudry, I. H. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2854 · Cited by 90 · see citing works

Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS

Alexander, A., Irving, A. J., & Harvey, J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.003 · Cited by 86 · see citing works

GPER expressed on microglia mediates the anti‐inflammatory effect of estradiol in ischemic stroke

Zhao, T., Ding, Q., Hu, J., He, S., Shi, F., & Ma, L. (2016) · Brain and Behavior · doi:10.1002/brb3.449 · Cited by 83 · see citing works

Extra‐nuclear signaling of estrogen receptors

Fu, X., & Simoncini, T. (2008) · IUBMB Life · doi:10.1002/iub.80 · Cited by 81 · see citing works

Estrogen induces rapid translocation of estrogen receptor β, but not estrogen receptor α, to the neuronal plasma membrane

Sheldahl, L. C., Shapiro, R. A., Bryant, D. N., Koerner, I. P., & Dorsa, D. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.035 · Cited by 77 · see citing works

The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease

Baraka, A., Korish, A. A., Soliman, G. A., & Kamal, H. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.03.010 · Cited by 73 · see citing works

G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons

Ruiz-Palmero, I., Hernando, M. J., García‐Segura, L. M., & Arévalo, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.018 · Cited by 72 · see citing works

GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol

Yates, M. A., Li, Y., Chlebeck, P. J., & Offner, H. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-20 · Cited by 72 · see citing works

A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release

Briz, V., Liu, Y., Zhu, G., Bi, X., & Baudry, M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201504092 · Cited by 72 · see citing works

Rapid effects of dorsal hippocampal G-protein coupled estrogen receptor on learning in female mice

Lymer, J., Robinson, A., Winters, B. D., & Choleris, E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.019 · Cited by 69 · see citing works

Estrogen Stimulates Proliferation and Differentiation of Neural Stem/Progenitor Cells through Different Signal Transduction Pathways

Okada, M., Makino, A., Nakajima, M., Okuyama, S., Furukawa, S., & Furukawa, Y. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11104114 · Cited by 68 · see citing works

G-protein coupled estrogen receptor 1 expression in rat and human heart: Protective role during ischaemic stress

Randeva (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000452 · Cited by 68 · see citing works

Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum

Almey, A., Milner, T. A., & Brake, W. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.023 · Cited by 68 · see citing works

G Protein–Coupled Estrogen Receptor Agonist Improves Cerebral Microvascular Function After Hypoxia/Reoxygenation Injury in Male and Female Rats

Murata, T., Dietrich, H. H., Xiang, C., & Dacey, R. G. (2013) · Stroke · doi:10.1161/strokeaha.112.678177 · Cited by 67 · see citing works

Estrogen destabilizes microtubules through an ion‐conductivity‐independent TRPV1 pathway

Goswami, C., Kuhn, J., Dina, O. A., Fernandez-Ballester, G. J., Levine, J. D., Ferrer-Montiel, A. V., & Hucho, T. B. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07270.x · Cited by 64 · see citing works

GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner

Kastenberger, I., & Schwarzer, C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.09.001 · Cited by 63 · see citing works

Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice

Bourque, M., Morissette, M., & Paolo, T. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.017 · Cited by 62 · see citing works

Chronic treatment with a GPR30 antagonist impairs acquisition of a spatial learning task in young female rats

Hammond, R., Nelson, D. A., Kline, E. G., & Gibbs, R. B. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.07.004 · Cited by 61 · see citing works

Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia

Khan, M. M., Wakade, C. G., Sevilla, L. M. D., & Brann, D. W. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.05.001 · Cited by 61 · see citing works

Activation of G-protein-coupled receptor 30 is sufficient to enhance spatial recognition memory in ovariectomized rats

Hawley, W. R., Grissom, E. M., Moody, N. M., Dohanich, G. P., & Vasudevan, N. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.006 · Cited by 61 · see citing works

GPER1/GPR30 Activation Improves Neuronal Survival Following Global Cerebral Ischemia Induced by Cardiac Arrest in Mice

Kosaka, Y., Quillinan, N., Bond, C. T., Traystman, R. J., Hurn, P. D., & Herson, P. S. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0211-8 · Cited by 60 · see citing works

Characterization of the G‐protein‐coupled membrane‐bound estrogen receptor GPR30 in the zebra finch brain reveals a sex difference in gene and protein expression

Acharya, K. D., & Veney, S. L. (2011) · Developmental Neurobiology · doi:10.1002/dneu.22004 · Cited by 59 · see citing works

Activation of G protein-coupled estrogen receptor 1 (GPER-1) ameliorates blood-brain barrier permeability after global cerebral ischemia in ovariectomized rats

Lu, D., Qu, Y., Shi, F., Feng, D., Tao, K. X., Gao, G., He, S., & Zhao, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.044 · Cited by 58 · see citing works

Effects of estrogens on proliferation and differentiation of neural stem/progenitor cells

Okada, M., MURASE, K., Makino, A., Nakajima, M., Kaku, T., Furukawa, S., & Furukawa, Y. (2008) · Biomedical Research · doi:10.2220/biomedres.29.163 · Cited by 58 · see citing works

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1

Bourque, M., Morissette, M., & Paolo, T. D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.006 · Cited by 56 · see citing works

Implication of GPER1 in neuroprotection in a mouse model of Parkinson's disease

Bourque, M., Morissette, M., Côté, M., Soulet, D., & Paolo, T. D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.022 · Cited by 56 · see citing works

Oestrogens Prevent Loss of Dopamine Transporter (DAT) and Vesicular Monoamine Transporter (VMAT2) in Substantia Nigra of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Mice

Jourdain, S., Morissette, M., Morin, N., & Paolo, T. D. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01337.x · Cited by 56 · see citing works

Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury.

Wang, Z.-F., Pan, Z.-Y., Xu, C.-S., & Li, Z.-Q. (2017) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2016.11.138 · Cited by 56 · see citing works

G Protein-Coupled Estrogen Receptor in Energy Homeostasis and Obesity Pathogenesis

Shi, H., Kumar, S. P. D. S., & Liu, X. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00006-6 · Cited by 54 · see citing works

Estrogen Signaling in the Hypothalamus

Kelly, M. J., Qiu, J., & Rønnekleiv, O. K. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71005-0 · Cited by 54 · see citing works

Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol

Kastenberger, I., Lutsch, C., & Schwarzer, C. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2599-3 · Cited by 54 · see citing works

Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats

Duarte‐Guterman, P., Lieblich, S. E., Chow, C., & Galea, L. A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129880 · Cited by 54 · see citing works

Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice

Broughton, B. R. S., Brait, V. H., Guida, E., Lee, S., Arumugam, T. V., Gardiner-Mann, C. V., Miller, A. A., Tang, S., Drummond, G. R., & Sobey, C. G. (2012) · Neurosignals · doi:10.1159/000338019 · Cited by 54 · see citing works

GPER Agonist G1 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson Disease

Guan, J., Yang, B., Fan, Y., & Zhang, J. (2017) · NeuroImmunoModulation · doi:10.1159/000478908 · Cited by 53 · see citing works

Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer's disease

Kubota, T., Matsumoto, H., & Kirino, Y. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.06.005 · Cited by 52 · see citing works

The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion

Ma, Y., Qin, P., Li, Y.-Y., Shen, L., Wang, S., Dong, H., Hou, W., & Xiong, L. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-118 · Cited by 52 · see citing works

Activation of the G-protein coupled receptor 30 (GPR30) has different effects on anxiety in male and female mice.

Hart, D., Nilges, M., Pollard, K., Lynn, T., Patsos, O. P., Shiel, C., Clark, S., & Vasudevan, N. (2014) · Steroids · doi:10.1016/j.steroids.2013.11.004 · Cited by 51 · see citing works

A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster

Canonaco, M., Giusi, G., Madeo, A., Facciolo, R. M., Lappano, R., Canonaco, A., & Maggiolini, M. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0392 · Cited by 47 · see citing works

Estrogen and non‐genomic upregulation of voltage‐gated Na+ channel activity in MDA‐MB‐231 human breast cancer cells: Role in adhesion

Fraser, S. P., Ozerlat‐Gunduz, I., Onkal, R., Diss, J. K. J., Latchman, D. S., & Djamgoz, M. B. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22154 · Cited by 46 · see citing works

GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment

Mendes‐Oliveira, J., Campos, F. L., Videira, R. A., & Baltazar, G. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.016 · Cited by 46 · see citing works

Purification of estradiol receptor from rat uterus and blockade of its estrogen-binding function by specific antibody

Soloff, M. S., & Szego, C. M. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90540-3 · Cited by 43 · see citing works

G protein‐coupled receptor 30 contributes to improved remyelination after cuprizone‐induced demyelination

Hirahara, Y., Matsuda, K., Yamada, H., Saitou, A., Morisaki, S., Takanami, K., Boggs, J. M., & Kawata, M. (2012) · Glia · doi:10.1002/glia.22445 · Cited by 43 · see citing works

Activation of GPR30 attenuates chronic pain-related anxiety in ovariectomized mice

Liu, S., Tian, Z., Guo, Y., Zhang, N., Feng, B., & Zhao, M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.021 · Cited by 43 · see citing works

G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury*

Hu, R., Sun, H., Zhang, Q., Chen, J., Wu, N., Meng, H., Cui, G., Hu, S. J., Li, F., Lin, J., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182657560 · Cited by 43 · see citing works

G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium

Tica, A. A., Dun, E. C., Tica, O. S., Gao, X. Y., Arterburn, J. B., Brailoiu, G. C., Oprea, T. I., & Brailoiu, E. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00501.2010 · Cited by 42 · see citing works

GDNF Contributes to Oestrogen‐Mediated Protection of Midbrain Dopaminergic Neurones

Campos, F. L., Cristóvão, A. C., Rocha, S. M., Fonseca, C. P., & Baltazar, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02348.x · Cited by 41 · see citing works

ERα-associated protein networks

Schultz-Norton, J. R., Ziegler, Y., & Nardulli, A. M. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.11.005 · Cited by 38 · see citing works

Notch/Neurogenin 3 Signalling is Involved in the Neuritogenic Actions of Oestradiol in Developing Hippocampal Neurones

Ruiz-Palmero, I., Simon‐Areces, J., García‐Segura, L. M., & Arévalo, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02110.x · Cited by 37 · see citing works

Effects of Long-Term Treatment with Estradiol and Estrogen Receptor Subtype Agonists on Serotonergic Function in Ovariectomized Rats

Benmansour, S., Adeniji, O. S., Privratsky, A. A., & Frazer, A. (2015) · Neuroendocrinology · doi:10.1159/000437268 · Cited by 36 · see citing works

G-protein-coupled receptor 30-mediated antiapoptotic effect of estrogen on spinal motor neurons following injury and its underlying mechanisms

Chen, J., Hu, R., Ge, H., Duanmu, W., Li, Y., XUE, X., HU, S., & Feng, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3601 · Cited by 35 · see citing works

GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice

Xu, W. R., Cao, J., Zhou, Y., Wang, L., & Zhu, G. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.02.005 · Cited by 35 · see citing works

G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice

Cheng, Q., Meng, J., Wang, X., Kang, W., Tian, Z., Zhang, K., Liu, G., & Zhao, J.-N. (2016) · Bioscience Reports · doi:10.1042/bsr20160134 · Cited by 33 · see citing works

GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus

McAllister, C. E., Creech, R. D., Kimball, P. A., Muma, N. A., & Li, Q. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.018 · Cited by 32 · see citing works

Reprint of ”GPR30 mediates estrogen rapid signaling and neuroprotection”

Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. M., Yang, F., Brann, D. W., & Wang, R. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.05.005 · Cited by 31 · see citing works

Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus

Gibbs, R. B., Nelson, D. A., & Hammond, R. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.06.002 · Cited by 30 · see citing works

Decreased levels of G protein-coupled estrogen receptor in children with autism spectrum disorders

Altun, H., Kurutaş, E. B., Şahın, N., Sınır, H., & Fındıklı, E. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.06.008 · Cited by 29 · see citing works

GPR30 activation is neither necessary nor sufficient for acute neuroprotection by 17β-estradiol after an ischemic injury in organotypic hippocampal slice cultures

Lamprecht, M. R., & Morrison, B. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.037 · Cited by 27 · see citing works

The membrane‐type estrogen receptor G‐protein‐coupled estrogen receptor suppresses lipopolysaccharide‐induced interleukin 6 via inhibition of nuclear factor‐kappa B pathway in murine macrophage cells

Okamoto, M., Suzuki, T., Mizukami, Y., & Ikeda, T. (2017) · Animal Science Journal · doi:10.1111/asj.12868 · Cited by 27 · see citing works

G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes

Roque, C., Mendes‐Oliveira, J., & Baltazar, G. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14648 · Cited by 27 · see citing works

Dissociable involvement of estrogen receptors in perirhinal cortex-mediated object-place memory in male rats

Mitchnick, K. A., Mendell, A. L., Wideman, C. E., Jardine, K. H., Creighton, S. D., Muller, A.-M., Choleris, E., MacLusky, N. J., & Winters, B. D. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.005 · Cited by 27 · see citing works

GPER: A new tool to protect dopaminergic neurons?

Bessa, A., Campos, F. L., Videira, R. A., Mendes‐Oliveira, J., Bessa‐Neto, D., & Baltazar, G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.07.004 · Cited by 27 · see citing works

Serum levels of G protein-coupled estrogen receptor 1 (GPER1) in drug-naive patients with generalized anxiety disorder

Fındıklı, E., Camkurt, M. A., Karaaslan, M. F., Kurutaş, E. B., Altun, H., İzci, F., Fındıklı, H. A., & Kardaş, S. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.098 · Cited by 25 · see citing works

GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP+-Induced SH-SY5Y Cell Death

Cheng, Y.-F., Zhu, G., Qingwen, W., Xie, Y., Jiang, Y., Guo, L., Guan, Y.-L., Liu, Y., & Zhang, J. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0856-y · Cited by 22 · see citing works

Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system

Dluzen, D. E., & Mickley, K. R. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.10.007 · Cited by 20 · see citing works

Downregulation of G‑protein‑coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis

Wu, Y., Feng, D., Lin, J., Qu, Y., He, S., Wang, Y., Gao, G., & Zhao, T. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8618 · Cited by 14 · see citing works

Serum levels of GPER -1 in euthymic bipolar patients

Orhan, F. Ö., Kurutaş, E. B., Doğaner, A., Türker, E., Taner, S. Ş., Güngör, M., & Çakmak, S. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s158822 · Cited by 12 · see citing works

Estrogen Replacement Therapy for Stroke

Pabon, M. M., Tamboli, C., Tamboli, S., Acosta, S., de la Peña, I., Sanberg, P. R., Tajiri, N., Kaneko, Y., & Borlongan, C. V. (2013) · Cell Medicine · doi:10.3727/215517913x672263 · Cited by 10 · see citing works

GnRH Neurons of Young and Aged Female Rhesus Monkeys Co-Express GPER but Are Unaffected by Long-Term Hormone Replacement

Naugle, M. M., & Gore, A. C. (2014) · Neuroendocrinology · doi:10.1159/000369820 · Cited by 8 · see citing works

Role of estrogen receptors in health and disease

Chen, P., Li, B., & Ou-Yang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839005 · Cited by 339 · see citing works

G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications

Arterburn, J. B., & Prossnitz, E. R. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031122-121944 · Cited by 114 · see citing works

Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease

Mauvais‐Jarvis, F., Lange, C. A., & Levin, E. R. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab041 · Cited by 95 · see citing works

On the role of sex steroids in biological functions by classical and non-classical pathways. An update

Pillerová, M., Borbélyová, V., Hodosy, J., RILJAK, V., Renczés, E., Frick, K. M., & Tóthová, Ľ. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100926 · Cited by 78 · see citing works

Sex shapes gut–microbiota–brain communication and disease

Hokanson, K. C., Hernández, C., Deitzler, G. E., Gaston, W. J., & David, M. M. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.08.013 · Cited by 55 · see citing works

Emerging Evidence on Membrane Estrogen Receptors as Novel Therapeutic Targets for Central Nervous System Pathologies

Wnuk, A., Przepiórska, K., Pietrzak, B. A., & Kajta, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044043 · Cited by 43 · see citing works

Involvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Review

Upadhayay, S., Gupta, R., Singh, S., Mundkar, M., Singh, G., & Kumar, P. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01301-9 · Cited by 35 · see citing works

Sex-dependent effects of GPER activation on neuroinflammation in a rat model of traumatic brain injury

Pan, M., Li, J., Ma, C., Fu, K., Li, Z., & Wang, X. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.005 · Cited by 28 · see citing works

GPER: An Estrogen Receptor Key in Metastasis and Tumoral Microenvironments

Tirado-Garibay, A. C., Falcón-Ruiz, E. A., Ochoa‐Zarzosa, A., & López-Meza, J. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914993 · Cited by 24 · see citing works

The role of ERα36 in cell type-specific functions of estrogen and cancer development

Mahboobifard, F., Dargahi, L., Jorjani, M., Tehrani, F. R., & Pourgholami, M. H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105307 · Cited by 24 · see citing works

Epimedin B exerts neuroprotective effect against MPTP-induced mouse model of Parkinson's disease: GPER as a potential target

Zhang, M., Hu, Z., Dong, X., & Chen, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113955 · Cited by 23 · see citing works

E2-BSA and G1 exert neuroprotective effects and improve behavioral abnormalities following traumatic brain injury: The role of classic and non-classic estrogen receptors

Amirkhosravi, L., Khaksari, M., Soltani, Z., Esmaeili‐Mahani, S., Karam, G. A., & Hoseini, M. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147168 · Cited by 22 · see citing works

Fruit and vegetable consumption in relation to primary headaches: the MEPHASOUS study

Mansouri, M., Sharifi, F., Varmaghani, M., Shokri, A., Rahdar, H., Keshtkar, A., & Sadeghi, O. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-00984-7 · Cited by 18 · see citing works

Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice

Yoo, D. Y., Jung, S., Kang, J. S., Baek, J. H., Park, K. H., Lee, D. H., Kang, S. S., & Kim, H. J. (2022) · Nutrients · doi:10.3390/nu14224753 · Cited by 17 · see citing works

d-dimer and diffusion-weighted imaging pattern as two diagnostic indicators for cancer-related stroke

Shen, Y., Li, Y., Chen, C., Wang, W.-A., & Li, T. X. (2020) · Medicine · doi:10.1097/md.0000000000018779 · Cited by 16 · see citing works

Selective effects of estradiol on human corneal endothelial cells

Han, S.-Y., Mueller, C., Wuebbolt, C., Kilcullen, S., Nayyar, V., Gonzalez, B. C., Fard, A. M., Floss, J. C., Morales, M. J., & Patel, S. P. (2023) · Scientific Reports · doi:10.1038/s41598-023-42290-z · Cited by 15 · see citing works

Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model

Xiao, L., Jiang, S., Wang, Y., Gao, C., Liu, C., Huo, X., Li, W., Guo, B., Wang, C., Sun, Y., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03787-9 · Cited by 16 · see citing works

Breakfast consumption is inversely associated with primary headaches in university students: The MEPHASOUS study

Mansouri, M., Sharifi, F., Shokri, A., Varmaghani, M., Yaghubi, H., Tabrizi, Y. M., & Sadeghi, O. (2021) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2021.102663 · Cited by 15 · see citing works

Raloxifene and Fulvestrant Exert Antioxidant, Anti‐Inflammatory, and Antiapoptotic Action Against Haloperidol‐Induced Tardive Dyskinesia in Rats via Activation of the GPER1/PI3k/Akt/Nrf2/HO‐1 Signaling Pathways

Upadhayay, S., Soni, D., & Kumar, P. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70413 · Cited by 13 · see citing works

Peering into the Brain’s Estrogen Receptors: PET Tracers for Visualization of Nuclear and Extranuclear Estrogen Receptors in Brain Disorders

Arjmand, S., Bender, D., Jakobsen, S., Wegener, G., & Landau, A. M. (2023) · Biomolecules · doi:10.3390/biom13091405 · Cited by 13 · see citing works

Activation of GPR30 Ameliorates Cerebral Ischemia–Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway

Zhang, Y., Sun, T., Zhao, Z., Fu, J. W., Yang, L., Xu, Y., Zhao, J., Tang, X., Liu, A., & Zhao, M. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08801-5 · Cited by 13 · see citing works

Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes

Mei, Z., Liu, J., Bennett, D. A., Seyfried, N., Wingo, A. P., & Wingo, T. S. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70206 · Cited by 11 · see citing works

Zebrafish as an emerging model to study estrogen receptors in neural development

Boueid, M., El-Hage, O., Schumacher, M., Degerny, C., & Tawk, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1240018 · Cited by 11 · see citing works

Transcript levels of 4 genes in umbilical cord blood are predictive of later autism development: a longitudinal follow-up study

Jia, Q., Li, H., Wang, M., Wei, C., Xu, L., Ye, L., Wang, C., Ke, S., Li, L., & Yao, P. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230046 · Cited by 10 · see citing works

G protein-coupled estrogen receptor (GPER) selective agonist G1 attenuates the neurobehavioral, molecular and biochemical alterations induced in a valproic acid rat model of autism

Abdel‐Hameed, R., Ahmed, E. K., Mahmoud, A. A., & Atef, A. A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121860 · Cited by 9 · see citing works

The effects of GPER on age-associated memory impairment induced by decreased estrogen levels

Luo, W., Yan, Y., Cao, Y., Zhang, Y., & Zhang, Z. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1097018 · Cited by 8 · see citing works

GPER involvement in inflammatory pain

Jouffre, B., Acramel, A., Jacquot, Y., Daulhac, L., & Mallet, C. (2023) · Steroids · doi:10.1016/j.steroids.2023.109311 · Cited by 8 · see citing works

Selective Activation of G Protein–Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage

Liang, Y., Fu, W., Tang, Y., Ye, H., Wang, Y., Sun, C., Xiang, Y., Xiong, W., Cui, M., Chen, Y., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04312-3 · Cited by 8 · see citing works

The spatial and temporal pattern of GPER/GPR30 reporter expression in the developing and mature forebrain of mice

Wu, M., He, W., Gong, H., Dong, L., Ding, N., Zhang, G., Wang, J., & Rong, W. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111276 · Cited by 6 · see citing works

Prenatal exposure of diabetes and progestin‐mediated autistic biomarker in peripheral blood mononuclear cells

Jiao, Y., Wang, M., Li, H., Jia, Q., Xu, L., Zhong, L., Huang, J., Li, L., Xiang, W., & Yao, P. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15935 · Cited by 6 · see citing works

Estrogen receptor agonists induce anti‑edema effects by altering α and β estrogen receptor gene expression

Khaksari, M., Hajializadeh, Z., Esmaeili‐Mahani, S., Soltani, Z., & Asadikaram, G. (2021) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2021-027 · Cited by 5 · see citing works

The Ca2+ Bridge: From Neurons to Circuits in Rett Syndrome

Molina, L., Arancibia, Y., Alarcón, J., & Torres, R. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110490 · Cited by 4 · see citing works

Estrogen signaling processes in fibroblasts: a scoping review

Roy, N., Casarini, L., Smetanina, D., Awar, S. A., & Zaręba, K. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1768772 · Cited by 2 · see citing works

The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke

Ferreira, L. O., de Souza, R. D., Teixeira, L. L., Pinto, L. C., Rodrigues, J. C. M., Filho, A. J. M., da Costa, E. T., Hamoy, M., & Lopes, D. C. F. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad061 · Cited by 3 · see citing works

Neurosteroidy - modulatory ośrodkowego układu nerwowego

Leśkiewicz, M. (2020) · Kosmos · doi:10.36921/kos.2020_2676

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Hurşıtoğlu, O., Kurutaş, E. B., Uygur, Ö. F., & Öztürk, N. (2023) · Genel Tıp Dergisi · doi:10.54005/geneltip.1271033

Reproductive system

Yin, X., & Wu, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91795-7.00017-8

Additional file 3 of Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model

Xiao, L., 蒋树财, Wang, Y., Gao, C., Liu, C., Huo, X., Li, W., Guo, B., Wang, C., Sun, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26550871

Additional file 1 of Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model

Xiao, L., 蒋树财, Wang, Y., Gao, C., Liu, C., Huo, X., Li, W., Guo, B., Wang, C., Sun, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26550865

Additional file 2 of Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model

Xiao, L., 蒋树财, Wang, Y., Gao, C., Liu, C., Huo, X., Li, W., Guo, B., Wang, C., Sun, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26550868

Antinociception and neuroprotection of the peptidic G protein‐coupled estrogen receptor inverse agonist PLMI in the murine model of paclitaxel‐induced peripheral neuropathy

Jouffre, B., Acramel, A., Coric, P., Gousseau, P., Barbier, J., Aissouni, Y., Daulhac, L., Bouaziz, S., Jacquot, Y., & Mallet, C. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70496

Involvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Review

Upadhayay, S., Gupta, R., Singh, S., Mundkar, M., Singh, G., & Kumar, P. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01301-9 · Cited by 35 · see citing works

G protein-coupled estrogen receptor 1 and its role in sex-specific differences in neurological and cardiovascular diseases

Dräger, O., Gottschalk, J., Wischmeyer, E., & Windmöller, B. A. (2024) · Gene & Protein in Disease · doi:10.36922/gpd.4632 · Cited by 5 · see citing works

38 IS THE NOVEL G PROTEIN-COUPLED ESTROGEN RECEPTOR A SEX SPECIFIC TARGET FOLLOWING STROKE?

Broughton, B. R. S., Brait, V. H., Lee, S., Guida, E., Gardiner-Mann, C. V., Miller, A. A., Arumugam, T. V., Drummond, G. R., & Sobey, C. G. (2012) · Journal of Hypertension · doi:10.1097/01.hjh.0000419864.59776.cb

Exploring the physiological role of the G protein-coupled estrogen receptor (GPER) and its associations with human diseases

Żabińska, M., Wiśniewska, K., Węgrzyn, G., & Pierzynowska, K. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107070 · Cited by 24 · see citing works

Sex-Dependent Effects of G Protein–Coupled Estrogen Receptor Activity on Outcome After Ischemic Stroke

Broughton, B. R. S., Brait, V. H., Kim, H. A., Lee, S., Chu, H. X., Gardiner-Mann, C. V., Guida, E., Evans, M. A., Miller, A. A., Arumugam, T. V., et al. (2014) · Stroke · doi:10.1161/strokeaha.113.001499 · Cited by 100 · see citing works