The DOI matches its Crossref record; 50 of the 55 references it cites were found in a registry or an index.
Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers
Abstract
Objectives Ovarian carcinoma cells form multicellular aggregates, or spheroids, in the peritoneal cavity of patients with advanced disease. The current paradigm that ascites spheroids are non-adhesive leaves their contribution to ovarian carcinoma dissemination undefined. Here, spheroids obtained from ovarian carcinoma patients' ascites were characterized for their ability to adhere to molecules encountered in the peritoneal cavity, with the goal of establishing their potential to contribute to ovarian cancer spread.Methods Spheroids were recovered from the ascites fluid of 11 patients with stage III or stage IV ovarian carcinoma. Adhesion assays to extracellular matrix (ECM) proteins and human mesothelial cell monolayers were performed for each of the ascites spheroid samples. Subsequently, inhibition assays were performed to identify the cell receptors involved.Results Most ascites samples adhered moderately to fibronectin and type I collagen, with reduced adhesion to type IV collagen and laminin. Monoclonal antibodies against the beta1 integrin subunit partially inhibited this adhesion. Ascites spheroids also adhered to hyaluronan. Additionally, spheroids adhered to live, but not fixed, human mesothelial cell monolayers, and this adhesion was partially mediated by beta1 integrins.Conclusions The cellular content of the ascites fluid has often been considered non-adhesive, but our findings are the first to suggest that patient-derived ascites spheroids can adhere to mesothelial extracellular matrix via beta1 integrins, indicating that spheroids should not be ignored in the dissemination of ovarian cancer.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“OVCAR-5 spheroids plated on a collagen-I coating, were observed to readily disaggregate with increasing collagen concentration, compared to laminin or collagen-IV coatings, thus highlighting its properties as a promoter of cancer cell adhesion and invasion (Burleson et al., 2004).”
From Three-dimensional modelling of ovarian cancer: from cell lines to organoids for discovery and personalized medicine (2022) · cites this paper as Burleson et al., 2004
Citations
Cites
Jemal, A., Murray, T., Samuels, A., Ghafoor, A., Ward, E., & Thun, M. J. (2003) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.53.1.5 · Cited by 3,275
Cell and environment interactions in tumor microregions: the multicell spheroid model.
Sutherland, R. M. (1988) · Science · doi:10.1126/science.2451290 · Cited by 1,803
CD44 and Its Interaction with Extracellular Matrix
Lesley, J., Hyman, R., & Kincade, P. W. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60537-4 · Cited by 1,059
Cannistra, S. (1993) · New England Journal of Medicine · doi:10.1056/nejmra041842 · Cited by 957
Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas 2
Sutherland, R. M., McCredie, J. A., & Inch, W. R. (1971) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/46.1.113 · Cited by 585
Hyaluronan-binding Proteins: Tying Up the Giant
Day, A. J., & Prestwich, G. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100036200 · Cited by 567
Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
Hardwick, C., Hoare, K., Owens, R. J., Hohn, H.-P., Höök, M., Moore, D. H., Cripps, V., Austen, L., Nance, D., & Turley, E. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.6.1343 · Cited by 403
Isolation, culture and characterization of human peritoneal mesothelial cells
Stylianou, E., Jenner, L. A., Davies, M., Coles, G. A., & Williams, J. D. (1990) · Kidney International · doi:10.1038/ki.1990.150 · Cited by 389
Cannistra, S. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311183292108 · Cited by 294
Effects of intercellular contact on repair of radiation damage
Durand, R. E., & Sutherland, R. M. (1972) · Experimental Cell Research · doi:10.1016/0014-4827(72)90265-0 · Cited by 287
Cited by
Sorted by citations
Ovarian Cancer Development and Metastasis
Lengyel, E. R. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100105 · Cited by 1,702
Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
Zhang, S., Balch, C., Chan, M. W. Y., Lai, H., Matei, D. E., Schilder, J. M., Yan, P. S., Huang, T. H. ‐., & Nephew, K. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0364 · Cited by 1,292
Spherical Cancer Models in Tumor Biology
Weiswald, L., Bellet, D. H., & Dangles‐Marie, V. (2015) · Neoplasia · doi:10.1016/j.neo.2014.12.004 · Cited by 1,194
Bapat, S. A., Mali, A. M., Koppikar, C. B., & Kurrey, N. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3931 · Cited by 770
Ovarian Cancer Metastasis: Integrating insights from disparate model organisms
Naora, H., & Montell, D. J. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1611 · Cited by 547
Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications
Ishiguro, T., Ohata, H., Sato, A., Yamawaki, K., Enomoto, T., & Okamoto, K. (2017) · Cancer Science · doi:10.1111/cas.13155 · Cited by 530
Mechanisms of transcoelomic metastasis in ovarian cancer
Tan, D. S. P., Agarwal, R., & Kaye, S. B. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70939-1 · Cited by 529
Hoarau-Véchot, J., Rafii, A., Touboul, C., & Pasquier, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010181 · Cited by 489
Multicellular spheroids in ovarian cancer metastases: Biology and pathology
Shield, K., Ackland, M. L., Ahmed, N., & Rice, G. E. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.11.032 · Cited by 412
Gubbels, J. A. A., Belisle, J. A., Onda, M., Rancourt, C., Migneault, M., Ho, M., Bera, T. K., Connor, J. P., Sathyanarayana, B. K., Lee, B., et al. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-50 · Cited by 423
Yin, M., Li, X., Tan, S., Zhou, H. J., Ji, W., Bellone, S., Xu, X., Zhang, H., Santin, A. D., Lou, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87252 · Cited by 423
Liao, J., Qian, F., Tchabo, N. E., Mhawech-Fauceglia, P. Y., Beck, A. F., Zikun, Q., Wang, X., Huss, W. J., Lele, S., Morrison, C. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084941 · Cited by 365
Mesothelial Cells Promote Early Ovarian Cancer Metastasis through Fibronectin Secretion
Kenny, H. A., Chiang, C.-Y., White, E. A., Schryver, E. M., Habis, M., Romero, I. L., Ladanyi, A., Penicka, C. V., George, J., Matlin, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74778 · Cited by 303
Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium
Iwanicki, M. P., Davidowitz, R. A., Ng, M. R., Besser, A., Muranen, T., Merritt, M., Danuser, G., Ince, T., & Brugge, J. S. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-11-0010 · Cited by 303
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer
Worzfeld, T., von Strandmann, E. P., Huber, M., Adhikary, T., Wagner, U. A. G., Reinartz, S., & Müller, R. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00024 · Cited by 296
Sodek, K. L., Ringuette, M. J., & Brown, T. J. (2009) · International Journal of Cancer · doi:10.1002/ijc.24188 · Cited by 248
The histophysiology and pathophysiology of the peritoneum
van Baal, J. O. A. M., de Vijver, K. K. V., Nieuwland, R., Noorden, C. J. F. V., van Driel, W. J., Sturk, A., Kenter, G. G., Rikkert, L. G., & Lok, C. A. R. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.11.004 · Cited by 242
Rizvi, I., Gurkan, U. A., Tasoglu, S., Alagic, N., Celli, J. P., Mensah, L. B., Mai, Z., Demirci, U., & Hasan, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216989110 · Cited by 234
Ahmed, N., Abubaker, K., Findlay, J., & Quinn, M. A. (2010) · Current Cancer Drug Targets · doi:10.2174/156800910791190175 · Cited by 237
Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
Schaffner, F., Ray, A., & Dontenwill, M. (2013) · Cancers · doi:10.3390/cancers5010027 · Cited by 234
Molecular description of a 3D in vitro model for the study of epithelial ovarian cancer (EOC)
Zietarska, M., Maugard, C. M., Filali‐Mouhim, A., Alam‐Fahmy, M., Tonin, P. N., Provencher, D. M., & Mes‐Masson, A. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20315 · Cited by 209
Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance
Teeuwssen, M., & Fodde, R. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101658 · Cited by 217
Epithelial ovarian cancer experimental models
Lengyel, E. R., Burdette, J. E., Kenny, H. A., Matei, D. E., Pilrose, J. M., Haluska, P., Nephew, K. P., Hales, D. B., & Stack, M. S. (2013) · Oncogene · doi:10.1038/onc.2013.321 · Cited by 213
Hudson, L. G., Zeineldin, R., & Stack, M. S. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9171-5 · Cited by 187
Thibault, B., Castells, M., Delord, J., & Couderc, B. C. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9456-2 · Cited by 191
Cell–cell and cell–matrix dynamics in intraperitoneal cancer metastasis
Sodek, K. L., Murphy, K., Brown, T. J., & Ringuette, M. J. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9351-2 · Cited by 157
Puiffe, M., Page, C. L., Filali-Mouhim, A., Zietarska, M., Ouellet, V., Tonin, P. N., Chevrette, M., Provencher, D. M., & Mes‐Masson, A. (2007) · Neoplasia · doi:10.1593/neo.07472 · Cited by 153
Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., Franco, W., Scarcelli, G., Polacheck, W. J., Roque, D. M., et al. (2021) · Cancers · doi:10.3390/cancers13174318 · Cited by 163
Disaggregation and invasion of ovarian carcinoma ascites spheroids
Burleson, K. M., Boente, M. P., Pambuccian, S. E., & Skubitz, A. P. N. (2006) · Journal of Translational Medicine · doi:10.1186/1479-5876-4-6 · Cited by 146
Development of Peritoneal Carcinomatosis in Epithelial Ovarian Cancer: A Review
van Baal, J. O. A. M., Noorden, C. J. F. V., Nieuwland, R., de Vijver, K. K. V., Sturk, A., van Driel, W. J., Kenter, G. G., & Lok, C. A. R. (2017) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417742897 · Cited by 145
Burleson, K. M., Hansen, L. K., & Skubitz, A. P. N. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-004-5768-5 · Cited by 150
Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles
Yousefi, M., Dehghani, S., Nosrati, R., Ghanei, M., Salmaninejad, A., Rajaie, S., Hasanzadeh, M., & Pasdar, A. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00513-9 · Cited by 146
Ahmed, N., Riley, C. B., Rice, G. E., & Quinn, M. A. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-005-1262-y · Cited by 140
Raghavan, S. A., Ward, M. R., Rowley, K. R., Wold, R. M., Takayama, S., Buckanovich, R. J., & Mehta, G. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.04.014 · Cited by 140
The Extracellular Matrix in Epithelial Ovarian Cancer – A Piece of a Puzzle
Cho, A., Howell, V. M., & Colvin, E. K. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00245 · Cited by 148
Mesenchymal gene program–expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance
Davidowitz, R. A., Selfors, L. M., Iwanicki, M., Elias, K. M., Karst, A. M., Piao, H., Ince, T. A., Drage, M. G., Dering, J., Konecny, G. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69815 · Cited by 132
Abubaker, K., Luwor, R. B., Zhu, H., McNally, O., Quinn, M. A., Burns, C. J., Thompson, E. W., Findlay, J. K., & Ahmed, N. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-317 · Cited by 128
Shield, K., Riley, C. B., Quinn, M. A., Rice, G. E., Ackland, M. L., & Ahmed, N. (2007) · Journal of Carcinogenesis · doi:10.1186/1477-3163-6-11 · Cited by 119
Structure and Function of Mesothelial Cells
Mutsaers, S. E., & Wilkosz, S. (2007) · Springer eBooks · doi:10.1007/978-0-387-48993-3_1 · Cited by 118
Li, A., Morton, J. P., Ma, Y., Karim, S. A., Zhou, Y., Faller, W. J., Woodham, E. F., Morris, H., Stevenson, R. P., Juin, A., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.046 · Cited by 117
Raghavan, S. A., Mehta, P., Ward, M. R., Bregenzer, M. E., Fleck, E. M. A., Tan, L., McLean, K., Buckanovich, R. J., & Mehta, G. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0133 · Cited by 116
Said, N. A., & Motamed, K. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61255-2 · Cited by 115
Tumor microenvironment in ovarian cancer peritoneal metastasis
Mei, S., Chen, X., Wang, K., & Chen, Y. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02854-5 · Cited by 112
Milky spots: omental functional units and hotbeds for peritoneal cancer metastasis
Liu, J., Geng, X.-F., & Li, Y. (2016) · Tumor Biology · doi:10.1007/s13277-016-4887-3 · Cited by 110
Oncologic Trogocytosis of an Original Stromal Cells Induces Chemoresistance of Ovarian Tumours
Rafii, A., Mirshahi, P., Poupot, M., Faussat, A., Simon, A., Ducros, E., Mery-Lamarche, E., Couderc, B. C., Lis, R., Capdet, J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003894 · Cited by 116
Tumor-Associated Macrophages (TAMs): A Critical Activator In Ovarian Cancer Metastasis
Yin, M., Shen, J., Yu, S., Jing, F., Zhu, X., Zhao, J., Zhai, L., Sadhukhan, A., & Zhou, J. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s216355 · Cited by 108
Moss, N. M., Barbolina, M. V., Liu, Y., Sun, L., Munshi, H. G., & Stack, M. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4151 · Cited by 105
Diagnosis and Management of Peritoneal Metastases from Ovarian Cancer
Halkia, E., Spiliotis, J. D., & Sugarbaker, P. H. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/541842 · Cited by 100
Finkernagel, F., Reinartz, S., Lieber, S., Adhikary, T., Wortmann, A., Hoffmann, N., Bieringer, T., Nist, A., Stiewe, T., Jansen, J. M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12180 · Cited by 95
M-Trap: Exosome-Based Capture of Tumor Cells as a New Technology in Peritoneal Metastasis
la Fuente, A. D., Alonso‐Alconada, L., Costa, C., Cueva, J. F., García‐Caballero, T., López‐López, R., & Abal, M. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv184 · Cited by 93
Correa, R. J. M., Peart, T. M., Valdés, Y. R., DiMattia, G. E., & Shepherd, T. G. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr241 · Cited by 93
SOX 2 is required to maintain cancer stem cells in ovarian cancer
Wen, Y., Hou, Y., Huang, Z., Cai, J., & Wang, Z. (2017) · Cancer Science · doi:10.1111/cas.13186 · Cited by 91
Kenny, H. A., Dogan, S., Zillhardt, M., Mitra, A. K., Yamada, S. D., Krausz, T. N., & Lengyel, E. R. (2009) · Cancer treatment and research · doi:10.1007/978-0-387-98094-2_16 · Cited by 94
Carduner, L., Picot, C. R., Leroy‐Dudal, J., Blay, L., Kellouche, S., & Carreiras, F. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.11.011 · Cited by 87
Autocrine VEGF‐A/KDR loop protects epithelial ovarian carcinoma cells from anoikis
Sher, I., Adham, S. A., Petrik, J., & Coomber, B. L. (2008) · International Journal of Cancer · doi:10.1002/ijc.23963 · Cited by 90
Said, N. A., Najwer, I., & Motamed, K. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060903 · Cited by 86
Usui, A., Ko, S. Y., Barengo, N., & Naora, H. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0489 · Cited by 85
Klymenko, Y., Kim, O., Loughran, E. A., Yang, J., Lombard, R., Alber, M., & Stack, M. S. (2017) · Oncogene · doi:10.1038/onc.2017.171 · Cited by 84
Hospicells (ascites-derived stromal cells) promote tumorigenicity and angiogenesis
Pasquet, M., Golzio, M., Mery, E., Rafii, A., Benabbou, N., Mirshahi, P., Hennebelle, I., Bourin, P., Allal, B., Teissie, J., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.24886 · Cited by 82
TGFβ signaling networks in ovarian cancer progression and plasticity
Kumari, A., Shonibare, Z., Monavarian, M., Arend, R. C., Lee, N. Y., Inman, G. J., & Mythreye, K. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10077-z · Cited by 78
Molecular mediators of peritoneal metastasis in pancreatic cancer
Avula, L. R., Hagerty, B. L., & Alewine, C. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09924-4 · Cited by 79
Buchanan, P. C., Boylan, K. L. M., Walcheck, B., Heinze, R., Geller, M. A., Argenta, P. A., & Skubitz, A. P. N. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.746859 · Cited by 73
Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer
Ghoneum, A., Almousa, S., Warren, B., Abdulfattah, A. Y., Shu, J., Abouelfadl, H., Gonzalez, D., Livingston, C., & Said, N. A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.024 · Cited by 72
Deng, X., ZHANG, P., LIANG, T., DENG, S., Chen, X., & Zhu, L. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2230 · Cited by 72
Correa, R. J. M., Valdés, Y. R., Peart, T. M., Fazio, E. N., Bertrand, M., McGee, J., Préfontaine, M., Sugimoto, A., DiMattia, G. E., & Shepherd, T. G. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu049 · Cited by 72
The Impact of Mesothelin in the Ovarian Cancer Tumor Microenvironment
Hilliard, T. S. (2018) · Cancers · doi:10.3390/cancers10090277 · Cited by 73
Dhaliwal, D., & Shepherd, T. G. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10136-5 · Cited by 76
Role of tumor microenvironment in ovarian cancer pathobiology
Ghoneum, A., Afify, H. M. A., Salih, Z. T., Kelly, M., & Said, N. A. (2018) · Oncotarget · doi:10.18632/oncotarget.25126 · Cited by 75
Giamougiannis, P., Martin‐Hirsch, P. L., & Martin, F. L. (2021) · Carcinogenesis · doi:10.1093/carcin/bgab010 · Cited by 75
Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer
Ray, U., Jung, D.-B., Jin, L., Xiao, Y., Dasari, S., Bhattacharya, S. S., Thirusangu, P., Staub, J. K., Roy, D., Roy, B., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0622 · Cited by 70
Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche
Condello, S., Sima, L. E., Ivan, C., Cárdenas, H., Schiltz, G. E., Mishra, R. K., & Matei, D. E. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2319 · Cited by 70
Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
Huang, Y., Liang, C.-Y., Ritz, D., Coelho, R., Septiadi, D., Estermann, M., Cumin, C., Rimmer, N., Schötzau, A., López, M. N., et al. (2020) · eLife · doi:10.7554/elife.59442 · Cited by 71
Ishiguro, T., Sato, A., Ohata, H., Ikarashi, Y., Takahashi, R., Ochiya, T., Yoshida, M., Tsuda, H., Onda, T., Kato, T., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0361 · Cited by 67
Yee, C., Dickson, K.-A., Muntasir, M. N., Ma, Y., & Marsh, D. J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.836984 · Cited by 66
Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids
Peart, T. M., Valdés, Y. R., Correa, R. J. M., Fazio, E. N., Bertrand, M., McGee, J., Préfontaine, M., Sugimoto, A. K., DiMattia, G. E., & Shepherd, T. G. (2015) · Oncotarget · doi:10.18632/oncotarget.4211 · Cited by 69
Molecular portraits of intratumoral heterogeneity in human ovarian cancer
Choi, Y. P., Shim, H. S., Gao, M., Kang, S., & Cho, N. H. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.03.018 · Cited by 65
Drug resistance evaluation in novel 3D in vitro model
Nowacka, M., Sterzyńska, K., Andrzejewska, M., Nowicki, M. O., & Januchowski, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111536 · Cited by 64
Long, L., Hu, Y., Long, T., Lu, X., Tuo, Y., Li, Y., Wang, M., & Ke, Z. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003973 · Cited by 63
Bilandzic, M., Rainczuk, A., Green, E., Fairweather, N., Jobling, T. W., Plebanski, M., & Stephens, A. N. (2019) · Cancers · doi:10.3390/cancers11091228 · Cited by 63
Clinical significance of ascites in epithelial ovarian cancer
Huang, H., Li, Y. J., Lan, C., Huang, Q., Feng, Y., HUANG, Y. W., & Liu, J. (2013) · Neoplasma · doi:10.4149/neo_2013_071 · Cited by 61
Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment
Worzfeld, T., Finkernagel, F., Reinartz, S., Konzer, A., Adhikary, T., Nist, A., Stiewe, T., Wagner, U. A. G., Looso, M., Graumann, J., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000400 · Cited by 61
Klymenko, Y., & Nephew, K. P. (2018) · Cancers · doi:10.3390/cancers10090295 · Cited by 63
Structural and functional identification of vasculogenic mimicry in vitro
Racordon, D., Valdivia, A., Mingo, G., Erices, R., Aravena, R., Santoro, F., Bravo, M. L., Ramírez, C., González, P., Sandoval, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07622-w · Cited by 58
Sluiter, N. R., de Cuba, E. M. V., Kwakman, R., Geert Kazemier, M., Meijer, G. A., & Velde, E. A. T. (2016) · Clinical & Experimental Metastasis · doi:10.1007/s10585-016-9791-0 · Cited by 59
Klymenko, Y., Johnson, J. K., Bos, B., Lombard, R., Campbell, L., Loughran, E. A., & Stack, M. S. (2017) · Neoplasia · doi:10.1016/j.neo.2017.04.002 · Cited by 61
Ho, C., Chang, S.-F., Hsiao, C.-C., Chien, T.-Y., & Shih, D. (2012) · Journal of Biomedical Science · doi:10.1186/1423-0127-19-23 · Cited by 58
Boylan, K. L. M., Buchanan, P. C., Manion, R. D., Shukla, D. M., Braumberger, K., Bruggemeyer, C., & Skubitz, A. P. N. (2016) · Oncotarget · doi:10.18632/oncotarget.14206 · Cited by 58
Ghoneum, A., Afify, H. M. A., Salih, Z. T., Kelly, M., & Said, N. A. (2018) · Cancer Medicine · doi:10.1002/cam4.1741 · Cited by 57
Cipollone, J., Graves, M. L., Köbel, M., Kalloger, S. E., Poon, T. K. C., Gilks, C. B., McNagny, K. M., & Roskelley, C. D. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9446-0 · Cited by 57
Das, T., Meunier, L., Barbe, L., Provencher, D. M., Guenat, O. T., Gervais, T., & Mes‐Masson, A. (2013) · Biomicrofluidics · doi:10.1063/1.4774309 · Cited by 59
Pease, J. C., BREWER, M. A., & Tirnauer, J. S. (2012) · Biology Open · doi:10.1242/bio.2012653 · Cited by 54
Hossein, G., Halvaei, S., Heidarian, Y., Dehghani‐Ghobadi, Z., Hassani, M., Hosseini, H., Naderi, N., & Hassani, S. S. (2019) · Cancer Medicine · doi:10.1002/cam4.2334 · Cited by 53
Microenvironmental Regulation of Ovarian Cancer Metastasis
Barbolina, M. V., Moss, N. M., Westfall, S. D., Liu, Y., Burkhalter, R. J., Marga, F. S., Forgács, G., Hudson, L. G., & Stack, M. S. (2009) · Cancer treatment and research · doi:10.1007/978-0-387-98094-2_15 · Cited by 53
Ascites and epithelial ovarian cancers: a reappraisal with respect to different aspects
Ayhan, A., Gültekin, M., Taşkıran, Ç., Dursun, P., Fırat, P., Bozdağ, G., Çelik, N., & Yuce, K. (2006) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2006.00777.x · Cited by 52
WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer
Kotrbova, A. V., Ovesná, P., Gybeľ, T., Radaszkiewicz, T. W., Bednaříková, M., Hausnerová, J., Jandáková, E., Minář, L., Crha, I., Weinberger, V., et al. (2019) · Theranostics · doi:10.7150/thno.37423 · Cited by 51
Llauradó, M., Abal, M., Castellví, J., Cabrera, S., Gil‐Moreno, A., Pérez‐Benavente, A., Colás, E., Doll, A., Dolcet, X., Matías‐Guiu, X., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26148 · Cited by 51
Bruney, L., Conley, K. C., Moss, N. M., Liu, Y., & Stack, M. S. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0155 · Cited by 50
Tong, J., Valdés, Y. R., Barrett, J. W., Bell, J. C., Stojdl, D. F., McFadden, G., McCart, J. A., DiMattia, G. E., & Shepherd, T. G. (2015) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2015.13 · Cited by 50
SMYD3 promotes implant metastasis of ovarian cancer via H3K4 trimethylation of integrin promoters
Lyu, T., Jiang, Y., Jia, N., Che, X., Qin, L., Yu, Y., Hua, K., Bast, R. C., & Feng, W. (2019) · International Journal of Cancer · doi:10.1002/ijc.32673 · Cited by 49
Advanced biomedical applications based on emerging 3D cell culturing platforms
Wang, A., Madden, L. A., & Paunov, V. N. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01658f · Cited by 50
Metadata
- Authors
- Burleson, K. M., Casey, R. C., Skubitz, K. M., Pambuccian, S. E., Oegema, T. R., & Skubitz, A. P. N.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Skubitz, Amy P.N
- Venue
- Gynecologic Oncology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 93
- Issue
- 1
- Pages
- 170-181
- ISSN
- 0090-8258 (ISSN-L)
- OpenAlex
- W1996604878
- Cited by
- 269
- References
- 55
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 14 · 2022: 11 · 2021: 24 · 2020: 23 · 2019: 12 · 2018: 13 · 2017: 17 · 2016: 13 · 2015: 13 · 2014: 21 · 2013: 18 · 2012: 11
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecologic Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- ovarian carcinoma, ascites, tumor spheroids, cell adhesion, extracellular matrix, mesothelial cells, beta1 integrin, fibronectin, collagen, hyaluronic acid, cancer dissemination, peritoneal carcinomatosis
- MeSH terms
- Ascites, Cell Adhesion, Epithelium, Extracellular Matrix, Female, Humans, Hyaluronic Acid, Neoplasm Staging, Ovarian Neoplasms, Peritoneal Cavity, Tumor Cells, Cultured, Extracellular Matrix Proteins, Spheroids, Cellular, Integrin beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
