Cited by 271Ovarian cancer diagnosis and treatmentCancer Cells and MetastasisCell Adhesion Molecules Research

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Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers

Burleson, Kathryn M, Casey, Rachael C, Skubitz, Keith M, Pambuccian, Stephan E, Oegema, Theodore R, Skubitz, Amy P.N·2004·Gynecologic Oncology

DOI 10.1016/j.ygyno.2003.12.034

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Abstract

Objectives Ovarian carcinoma cells form multicellular aggregates, or spheroids, in the peritoneal cavity of patients with advanced disease. The current paradigm that ascites spheroids are non-adhesive leaves their contribution to ovarian carcinoma dissemination undefined. Here, spheroids obtained from ovarian carcinoma patients' ascites were characterized for their ability to adhere to molecules encountered in the peritoneal cavity, with the goal of establishing their potential to contribute to ovarian cancer spread.Methods Spheroids were recovered from the ascites fluid of 11 patients with stage III or stage IV ovarian carcinoma. Adhesion assays to extracellular matrix (ECM) proteins and human mesothelial cell monolayers were performed for each of the ascites spheroid samples. Subsequently, inhibition assays were performed to identify the cell receptors involved.Results Most ascites samples adhered moderately to fibronectin and type I collagen, with reduced adhesion to type IV collagen and laminin. Monoclonal antibodies against the beta1 integrin subunit partially inhibited this adhesion. Ascites spheroids also adhered to hyaluronan. Additionally, spheroids adhered to live, but not fixed, human mesothelial cell monolayers, and this adhesion was partially mediated by beta1 integrins.Conclusions The cellular content of the ascites fluid has often been considered non-adhesive, but our findings are the first to suggest that patient-derived ascites spheroids can adhere to mesothelial extracellular matrix via beta1 integrins, indicating that spheroids should not be ignored in the dissemination of ovarian cancer.

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Authors: Burleson, K. M., Casey, R. C., Skubitz, K. M., Pambuccian, S. E., Oegema, T. R., & Skubitz, A. P. N.
Affiliations: University of Minnesota (US)
Corresponding author: Skubitz, Amy P.N
ORCID: Skubitz, Keith M
Skubitz, Amy P.N
Venue: Gynecologic Oncology
Publisher: Elsevier BV
Published: 2004-04
Volume: 93
Issue: 1
Pages: 170-181
ISSN: 0090-8258 (ISSN-L)
DOI: 10.1016/j.ygyno.2003.12.034
OpenAlex: W1996604878
Cited by: 269
References: 55
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 14 · 2022: 11 · 2021: 24 · 2020: 23 · 2019: 12 · 2018: 13 · 2017: 17 · 2016: 13 · 2015: 13 · 2014: 21 · 2013: 18 · 2012: 11
FWCI: 6.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gynecologic Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Minnesota
National Institutes of Health
Topics: Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: ovarian carcinoma, ascites, tumor spheroids, cell adhesion, extracellular matrix, mesothelial cells, beta1 integrin, fibronectin, collagen, hyaluronic acid, cancer dissemination, peritoneal carcinomatosis
MeSH terms: Ascites, Cell Adhesion, Epithelium, Extracellular Matrix, Female, Humans, Hyaluronic Acid, Neoplasm Staging, Ovarian Neoplasms, Peritoneal Cavity, Tumor Cells, Cultured, Extracellular Matrix Proteins, Spheroids, Cellular, Integrin beta1

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Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers

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