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Cited by 116

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression—Clinicopathological correlation

HAMMES, L, TEKMAL, R, NAUD, P, EDELWEISS, M, KIRMA, N, VALENTE, P, SYRJANEN, K, CUNHAFILHO, J·2007·Gynecologic Oncology
DOI 10.1016/j.ygyno.2006.11.023
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Abstract

Objective To evaluate the population of macrophages during the cervical malignant transformation and its influence in CIN outcome. Methods Biopsies from 26 normal cervix, 28 low-grade (LSIL), 30 high grade squamous intraepithelial lesions (HSIL) and 28 squamous cell carcinomas (SCC) were stained by H&E to assess inflammation and by immunohistochemistry with anti-CD68 to detect macrophages. The macrophage count was corrected for the epithelial and stromal compartments using appropriate software. Clinical and prospective follow-up data were also available. Results We identified that macrophage count increased linearly with disease progression (median count per case at x200 magnification: normal, 5.1; LSIL, 5.5; HSIL, 9.9; SCC, 14.5; P Conclusions The study on macrophages offers a potential approach for cervical cancer treatment, since macrophages are closely related to progression of CIN, and can be used as an applicable marker of such a risk.

Overview

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Crossref · 10.1016/j.ygyno.2006.11.023

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1 of 1 references verified0 citation errors · 0 not checkable

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Metadata

Authors
HAMMES, L., TEKMAL, R., NAUD, P., EDELWEISS, M., KIRMA, N., VALENTE, P., SYRJANEN, K., & CUNHAFILHO, J.
Venue
Gynecologic Oncology
Publisher
Elsevier BV
Published
2007-04
Volume
105
Issue
1
Pages
157-165
ISSN
0090-8258
DOI
10.1016/j.ygyno.2006.11.023
Cited by
116
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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