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Cited by 429

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

HPV vaccines – A review of the first decade

Open access
Harper, Diane M., DeMars, Leslie R.·2017·Gynecologic Oncology

Abstract

Pre-adolescent girls (9-15years) have the option of receiving a two dose HPV vaccine series at either a six month or one year interval to provide protection from HPV 16, the most prevalent type associated with cervical cancers, as well as several other less prevalent types. This series of vaccinations is highly likely to protect her from HPV infection until she enters the routine screening program, whether that be primary HPV testing or a combination of HPV testing and cytology. The two dose program has been recommended by the World Health Organization (WHO) since 2015. For women 15years and older, the three dose vaccine schedule is still recommended. The past ten years of Gardasil use has provided evidence of reduced HPV 16/18 infections in countries where there has been high coverage. Gardasil9 has replaced Gardasil. Gardasil9 has the same rapid anti-HPV 18 and HPV45 titer loss as Gardasil did. Cervarix remains equivalent to Gardasil9 in the prevention of HPV infections and precancers of any HPV type; Cervarix also has demonstrated sustained high antibody titers for at least 10years. One dose of Cervarix provides protection against HPV 16/18 infection with robust antibody titers well above natural infection titers. This may offer the easiest and most cost effective vaccination program over time, especially in low and lower middle income countries. Cervical cancer screening must continue to control cancer incidence over the upcoming decades. Future studies of prophylactic HPV vaccines, as defined by the WHO, must demonstrate protection against six month type specific persistent infections, not actual cervical cancer precursor disease endpoints, such as cervical intraepithelial neoplasia grade 3 (CIN 3) or adenocarcinoma in situ (AIS). This simplifies and makes less expensive future comparative studies between existing and new generic vaccines.

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Metadata

Authors
Harper, D. M., & DeMars, L. R.
Venue
Gynecologic Oncology
Publisher
Elsevier BV
Published
2017-07
Volume
146
Issue
1
Pages
196-204
ISSN
0090-8258 (ISSN-L)
OpenAlex
W2606020258
Cited by
429
References
50
FWCI
34.87
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: HPV vaccines – A review of the first decade. https://app.cochat.ai/papers/10.1016/j.ygyno.2017.04.004
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Harper, D. M., & DeMars, L. R. (2017). HPV vaccines – A review of the first decade. Gynecologic Oncology. https://doi.org/10.1016/j.ygyno.2017.04.004

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